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Request for Proposals

Translating Duke Health (TDH) Children's Health & Discovery Initiative (CHDI) Request for Proposals

Application deadline: January 25, 2021

The Translating Duke Health (TDH) Children’s Health and Discovery Initiative (CHDI) announces a request for research applications to the CHDI Pre-K Program, a year-long program to help Duke researchers develop career development/K-award applications to support research that investigates early life origins of disease.

I. Purpose

The goals of this RFA are to promote the development of externally funded research into the early life origins of health and disease, support new investigators in obtaining research career development awards (K awards).

CHDI Pre-K Awardees will receive:

  • Up to $50,000 in seed funding to:
    • Provide protected time for the Principal Investigator (please note that only up to half of the award may be used for salary support)
    • Support the development of pilot data for the application
  • Assistance in identifying collaborators and resources within Duke
  • Identification of relevant programming and resources to support application development and career development
  • Scientific writing support
  • Statistical support from CHDI’s data science team

II. Eligibility

The CHDI Pre-K Program is intended for investigators who do not yet hold and are eligible for an NIH K award (or equivalent career development award).

All awardees are expected to submit an individual K-award application within 3 months of the end of the award period. We plan to award up to six grants, each with a total budget of up to $50,000 (direct costs only) and a project duration of 1 year.

Please note that awardees must have an appointment within a clinical department in Duke School of Medicine or the research must be directly related to the clinical mission of Duke School of Medicine.

III. Details

  • Application submission deadline: January 25, 2021.

  • Funding: Each award will consist of up to $50,000 (inclusive of G&A), with an expected start date of March 1, 2021, and ending on February 28, 2022.

IV. Application Format

Applications should be organized as follows:

  • Cover page, including proposal title and the name and contact information of the Principal Investigator(s)
  • Project abstract (250 words max)
  • Draft specific aims for the K-award (1-page max, 11-point Arial font, half inch margins, not including references)
  • References
  • Rationale for CHDI support (1-page max)
  • Plans for career development award submission, including relevant funding opportunities, application deadlines, and approximate timelines for application development (2-pages max)
  • Budget and budget justification using PHS 398 Form pages 4 and 5
  • Human and/or animal subjects information
  • NIH-style biosketch for the Principal Investigator
  • Letter of support from the Principal Investigator’s Division Chief or Chair
  • Letter of support from the Principal Investigator’s Primary Mentor

V. Application Preparation

A consultation with the CHDI program director is available but not required. Please email Jillian Hurst at jillian.hurst@duke.edu if you would like to schedule a consultation.

VI. Selection Process and Review Criteria

  • Alignment with CHDI’s mission
  • Significance and Innovation
  • Investigator(s)
  • Potential for external funding

VII. Application Procedure

CHDI uses the MyResearchProposal online application software to submit applications.

  • To apply visit http://bit.ly/myresearchproposal, click on “Create New User” (or log in if you already have an account). Proposals must be submitted to the system by only one of the Principal Investigators.
  • A step-by-step user’s guide for applying via the MyResearchProposal software is available--please review the guide here.
  • Enter Access Code ‘CHDI’ and follow the instructions.
  • You will be prompted to enter the proposal title (80 characters max) and the name and email address of the Principal Investigator.

Proposal sections will be uploaded as a single PDF file consisting of the following documents:

  • Cover page, including proposal title and the name and contact information of the Principal Investigator(s) (1-page max)
  • Project abstract (250 words max)
  • Draft specific aims for the K award application (1-page max, 11-point Arial font, half inch margins, not including references)
  • References (please note that references do not count towards the total page limit and should be included at the end of the Specific Aims)
  • Rationale for CHDI support (1-page max) – indicate how the proposed work aligns with CHDI’s mission and how the program will support the development of your research program and career development award
  • Plans for external career development award application, including relevant funding opportunities, application deadlines, and approximate timelines for application development (2-pages max)

The following items will be uploaded as separate documents:

  • Budget and budget justification using PHS 398 Form pages 4 and 5 (no page limit)
  • Human and/or Animal Subjects: Institutional Review Board (IRB) or Institutional Animal Care & Use Committee (IACUC) approval is not required prior to submission but will be required prior to funding. Briefly describe any human and/or animal subject issues.
  • NIH-style biosketch for the Principal Investigator(s) in a single PDF

VIII. Budget Guidelines

Please note the following during budget preparation:

  • Budgets may not exceed $50,000
  • Awardees will receive direct costs only.
  • All funds are subject to G&A of up to 15% (please confirm the rate with your grants manager); the G&A should be included in the budget as part of the total award
  • Grant funds may be budgeted for:
    • PI salary support (please note that only up to half of the award may be used for this purpose)
    • Salary for research support personnel
    • Statistical and analytics support
    • Small equipment, subcontracts, research supplies and core lab costs directly related to the development of pilot data for the grant proposal
    • Other purposes deemed necessary for the successful development of the grant proposal
  • Grant funds may NOT be budgeted for:
    • Foreign components, as defined in the NIH grants policy
    • Effort for trainees who are already on training grant equivalents
    • Capital equipment
    • Office supplies or communication costs, unless deemed necessary to the development of pilot data
    • Meals or travel, including to conferences, except as required to collect data
    • Professional education or training
    • Computers or audiovisual equipment

Awarded funds must be used to aid in the development of an NIH K award career development award proposal (or equivalent award). CHDI reserves the right to revoke funding in the event it is determined that funds were not spent in accordance with the approved proposal without prior notification and approval.

IX. Terms of the Award

A. Program Execution

Investigators are expected to utilize the funding and support services provided by the CHDI to develop a K award (or equivalent) grant application during the 12-months of program support. Investigators will be required to hold a kick-off meeting prior to release of funds to develop a proposal development plan and will then be required to check-in with the CHDI program director on a monthly basis. Additionally, awardees will be required to hold at least three proposal review sessions. All proposals must be submitted within 6-months of program completion. Failure to participate in required components of the program may result in cancellation of funding.

B. Post-Award Reporting

CHDI tracks significant events resulting from the funding. Any significant events should be included in the final project report, and CHDI will contact investigators annually to determine if any significant events have been achieved as a result of this award. Examples include:

  • Funding applications and awards
  • Abstracts/presentations, manuscripts, published guidelines
  • Regulatory meetings and filings
  • Initiation of clinical studies
  • Implementation in clinical practice and community
  • Translation of models to other geographic areas
  • Translation of models to other therapeutic areas
  • Clinical outcomes in practice and communities
  • Agreements with partners and strategic collaborators to translate the research
  • Commercialization (e.g. new intellectual property, license, commercial partnerships, or start-up company)
  • Direct-to-consumer interactions (e.g., mobile applications) 

When requested, all awardees will be expected to provide updates of publications and other successes that originated from the award.