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Request for Proposals

Translating Duke Health (TDH) Children's Health & Discovery Initiative (CHDI) Request for Proposals

Application deadline: April 15, 2020

The Translating Duke Health (TDH) Children’s Health and Discovery Initiative (CHDI) announces a request for research applications to the CHDI Faculty Fellows Program, a year-long program to help Duke researchers develop grant applications to support research that investigates early life origins of disease.

I. Purpose

The goals of this RFA are to promote the development of externally funded research into the early life origins of health and disease, support new investigators in obtaining NIH (or equivalent funding), and to develop new multidisciplinary collaborations that leverage Duke’s unique resources and expertise.

CHDI Faculty Fellows will receive:

  • Up to $50,000 in support for:
    • PI salary and fringe benefits over a 12-month period
    • Seed funding to support the development of pilot data for the grant application
  • Assistance in identifying collaborators and resources within Duke
  • Mentoring in grant and research program development
  • Internal concept review sessions to help refine grant proposals
  • Administrative support for grant application development
  • Scientific writing support
  • Statistical support from CHDI’s data science team

II. Eligibility

The CHDI Faculty Fellows program is intended for:

  • Investigators who do not yet hold R01 (or equivalent funding), or
  • Investigators who are making a substantial change in their research focus

All Fellows are expected to submit an R01-level grant application within 3 months of the end of the award period. We plan to award up to four grants, each with a total budget of up to $50,000 (direct costs only) and a project duration of 1 year.

Please note that awardees must have an appointment within a clinical department in Duke School of Medicine or the research must be related to the clinical mission of Duke School of Medicine.

III. Details

  • Application submission deadline: April 15, 2020.
  • Funding: Each award will consist of up to $50,000 (inclusive of G&A), with an expected start date of July 1, 2020, and ending on June 30, 2021.

IV. Application Format

Applications should be organized as follows:

  • Cover page, including proposal title and the name and contact information of the Principal Investigator(s)
  • Project abstract (250 words max)
  • Specific aims (1-page max, 11-point Arial font, half inch margins, not including references)
  • References
  • Rationale for CHDI support (1-page max)
  • Plans for external grant submission, including relevant funding opportunities, application deadlines, and approximate timelines for application development
  • Budget and budget justification using PHS 398 Form pages 4 and 5
  • Human and/or animal subjects information
  • NIH-style biosketch for the Principal Investigator(s)

V. Application Preparation

A consultation with the CHDI program director is available but not required. Please email Jillian Hurst at jillian.hurst@duke.edu if you would like to schedule a consultation.

VI. Selection Process and Review Criteria

  • Alignment with CHDI’s mission
  • Significance and Innovation
  • Investigator(s)
  • Potential for external funding

VII. Application Procedure

CHDI uses the MyResearchProposal online application software to submit applications.

  • To apply visit http://bit.ly/myresearchproposal, click on “Create New User” (or log in if you already have an account).  Proposals must be submitted under the Principal Investigator’s name.
  • A step-by-step user’s guide for applying via the MyResearchProposal software is available here.
  • Enter Access Code ‘CHDI’ then select the “TDH CHDI Faculty Fellows 2020” funding opportunity and follow the instructions.
  • Click here for a direct link to the application. (Note: You will first be sent to the logon page after clicking the link.)
  • For any questions concerning MyResearchProposal passwords or system issues, please contact myresearchproposal@duke.edu or 919-668-4774.

Proposal sections will be uploaded as a single PDF file consisting of the following documents:

  • Cover page, including proposal title and the name and contact information of the Principal Investigator(s) (1-page max)
  • Project abstract (250 words max)
  • Specific aims (1-page max, 11-point Arial font, half inch margins, not including references)
  • References (please note that references do not count towards the total page limit and should be included at the end of the Specific Aims)
  • Rationale for CHDI support (1-page max) – indicate how the proposed work aligns with CHDI’s mission and how the program will support the development of your research program

The following items will be uploaded as separate documents:

  • Budget and budget justification using PHS 398 Form pages 4 and 5 (no page limit)
  • Human and/or Animal Subjects: Institutional Review Board (IRB) or Institutional Animal Care & Use Committee (IACUC) approval is not required prior to submission but will be required prior to funding. Briefly describe any human and/or animal subject issues.
  • NIH-style biosketch for the Principal Investigator(s) in a single PDF

VIII. Budget Guidelines

Please note the following during budget preparation:

  • Budgets may not exceed $50,000
  • Awardees will receive direct costs only.
  • All funds are subject to G&A of up to 15% (please confirm the rate with your grants manager); the G&A should be included in the budget as part of the total award
  • Grant funds may be budgeted for:
    • PI effort with fringe benefits
    • Salary for research support personnel
    • Statistical and analytics support
    • Small equipment, subcontracts, research supplies and core lab costs directly related to the development of pilot data for the grant proposal
    • Other purposes deemed necessary for the successful development of the grant proposal
  • Grant funds may NOT be budgeted for:
    • Foreign components, as defined in the NIH grants policy
    • Effort for trainees who are already on training grant equivalents
    • Capital equipment
    • Office supplies or communication costs, unless deemed necessary to the development of pilot data
    • Meals or travel, including to conferences, except as required to collect data
    • Professional education or training
    • Computers or audiovisual equipment
    • Manuscript preparation of submission

Awarded funds must be used to aid in the development of an R01-level grant proposal. CHDI reserves the right to revoke funding in the event it is determined that funds were not spent in accordance with the approved proposal without prior notification and approval.

IX. Terms of the Award

A. Program Execution

Investigators are expected to utilize the funding and support services provided by the CHDI to develop an R01 (or equivalent) grant application during the 12-months of program support. Investigators will be required to hold a kick-off meeting prior to release of funds to develop a proposal development plan and will then be required to check-in with the CHDI program director on a monthly basis. Additionally, CHDI fellows will be required to hold at least three proposal review sessions. All proposals must be submitted within 6-months of program completion. Failure to participate in required components of the program may result in cancellation of funding.

B. Post-Award Reporting

CHDI tracks significant events resulting from the funding. Any significant events should be included in the final project report, and CHDI will contact investigators annually to determine if any significant events have been achieved as a result of this award. Examples include:

  • Funding applications and awards
  • Abstracts/presentations, manuscripts, published guidelines
  • Regulatory meetings and filings
  • Initiation of clinical studies
  • Implementation in clinical practice and community
  • Translation of models to other geographic areas
  • Translation of models to other therapeutic areas
  • Clinical outcomes in practice and communities
  • Agreements with partners and strategic collaborators to translate the research
  • Commercialization (e.g. new intellectual property, license, commercial partnerships, or start-up company)
  • Direct-to-consumer interactions (e.g., mobile applications) 

When requested, all awardees will be expected to provide updates of publications and other successes that originated from the award.