The central mission of the Unified Program for Therapeutics in Children (UPTiC) is to train pediatrician-scientists to lead the development, implementation and evaluation of novel prophylactics and therapeutics for pediatric populations. By bringing together the remarkable breadth and strength of basic and clinical sciences at Duke University and the University of North Carolina at Chapel Hill, we have developed an integrated, pediatric research-focused training program available to all pediatric fellows centered on the fundamentals and practical aspects of research and development of therapeutics for children. Complementary strengths of the individual institutions offer synergy to the research and training missions of this program. This program fosters a fertile environment that spans departments and schools with an exceptionally broad range of training opportunities and mentors across each University, located just 9 miles apart.