Published Studies
How you can help
Our mission is to provide the professional infrastructure and clinical expertise directed toward improving the quality of care and long-term outcomes for our babies. Find out how you can help support our babies and our research.
Publications
The following publications from 2018-2020 highlight clinical studies completed at the Duke Neonatal Perinatal Research Unit.
Maternal Factors
Pulmonary
- Novel genes and associated pathways in determining respiratory outcomes in preterm births
- Use of diuretics in preterm infants
- Evaluating tube placement in infants less than 1 kilogram
- Furosemide exposure and prevention of BPD in preterm infants
- Race and association with BPD
- GRP and BPD
- Predictive model of extubation readiness in extremely preterm infants
- Outcomes associated with use of surfactants in preterm infants >30 weeks gestation
- Respiratory care during hospitalization for preterm infants
- Delivery room resuscitation in moderately preterm infants
Cardiovascular
- Atrial septal defects and bronchopulmonary dysplasia in premature infants
- Furosemide exposure and Patent Ductus Arteriosus in preterm infants
- Genetic variations associated with PDA in preterm infants
Neurology
- Early lumbar puncture and risk of intraventricular hemorrhage in preterm infants
- Long term outcomes for preterm infants
- Outcomes of whole body cooling for infants born with hypoxic-ischemic
- Outcome of preterm infants with transient cystic periventricular leukomalacia
Infection
- Antifungal susceptibility and clinical outcome in neonatal candidiasis
- Safety, effectiveness, and exposure-response of micafungin in infants
- Enterocolitis incidence and outcomes in very low birth weight infants
- Micafungin versus Amphotericin B Deoxycholate in infants with invasive candidiasis
- Exposure-response analysis of micafungin in neonatal candidiasis: Pooled analysis of two clinical trials
- Antifungal susceptibility and clinical outcome in neonatal candidiasis
- Use of Rifampin in infants
- Use of Ticrcillin-clavulanate in preterm infants
- Prolonged antibiotic exposure in preterm infants
- Use of Fluconazole in preterm and term infants
- Cefazolin use in preterm infants
- Breastmilk and antibodies
- Fluconazole prophylaxis use on susceptibility in preterm infants
- Adverse outcomes associated with postnatal CMV infection in preterm infants
- Clindamycin in infants: safety and effectiveness
- Evaluation of Ampicillin Pk model in infants with bacteremia
Gastrointestinal
- Predictors of prolonged breastmilk exposure in preterm infants
- Impact of G-tube placement on weight gain in preterm infants
- G-tube feeding in extremely low birthweight infants
- Variation in G-tube placement in preterm infants
- Disrupted maturation of the gut in extremely preterm infants
- Risk factors in NEC
- Fetal exposure to maternal microbiota
- Early life skin microbiota in hospitalized preterm and term infants
Ophthalmology
- Effects of inositol on retinopathy of prematurity in preterm infants
- Handheld spectral domain optical coherence tomography imaging through the undilated pupil in infants born with hypoxic injury or hydrocephalus
- ROP in very low birthweight infants
- Oxygen saturations and ROP in extreme preterm infants
- Longterm outcomes in preterm infants with ROP
Management of Complex Issues
- Admission temperature and associated mortality and morbidity among moderately and extremely preterm infants
- National survey of neonatal intensive care unit medication safety practices
- Prevalence and safety of diazoxide in the neonatal intensive care unit
- Morphine vs methadone treatment for infants with neonatal abstinence syndrome
- Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants
- Directory for neonatal intensive care
- Leveraging big data to inform pediatric development programs
- Sildenafil exposure in the neonatal intensive care unit
- Evaluation of gentamicin-induced ototoxicity in hospitalized infants
- Weaning of moderately preterm infants from the incubator to the crib
- Surgical necrotizing enterocolitis in extremely premature neonates
- Admission temperature and associated mortality and morbidity among moderately and extremely preterm infants
- Use of sedation for procedures
- Use of Sildenafil in the NICU
- Dosing and safety of caffeine citrate in preterm infants
- Glycogen Storage Disease Type III: need for systematic monitoring
- Inadequate oral feeding in moderately preterm infants
- Patterns of blood loss and transfusions in extremely low birthweight infants
- Sildenafil use in extremely premature infants
- Wide variation in caffeine discontinuation in preterm infants
- Sedation use during whole body cooling
- Policy changes for oxygen saturation alarm settings and outcomes
- Weaning of moderately preterm infants from incubator to the crib
- Hydrocortisone dosage on mortality in extremely preterm infants
- Safety profile of chloral hydrate vs other sedatives for procedure sedation in infants
- Medications and outcomes in infants born 22-24 weeks gestation
- Transfusion safety and outcomes in neonatal hyperbili
- Hepatopulmonary fusion in infants with CDH
Long-term Outcomes
- Use of midliner positioning system for prevention of dolichocephaly in preterm infants
- Extreme preterm infant rates of overweight and obesity at school age in the SUPPORT cohort
- Preterm infants treated with whole body cooling
- Long-term outcomes in patients with hemiplegia
- Genetic variation in motor development of infants born extremely preterm
- Developmental outcomes for extremely preterm infants needing CPS supervision
- Respiratory medications during the first year post-discharge
- Long-term outcomes in infants born extremely preterm
- Post-natal steroids for BPD and long-term outcomes
- Behavior profiles at 2 years of age for preterm infants with BPD
- Overweight and obesity at school age in extremely preterm infants
Genetics
- Mendelian disorders: a genocentric approach
- DeNovo Pathogenic Variants in CACNA1E
- Mutations in NCAPG2 causes sevree neurodevelopmental syndrome
Healthcare System Management/Research
- Duration of pediatric clinical trials submitted to the FDA
- Establishing pharmacokinetics model to electronic health records
- Drug development opportunities for preterm infants
- Characteristics of parents that consent to neonatal drug trials
- Validation of infant weight estimation device
How you can participate
If you currently have a baby in the Duke Intensive Care Nursery, and you think you may want to participate in any of our research studies, please ask your baby’s nurse or doctor to contact us. The NPRU team will then contact you to explain the criteria for study eligibility and describe the potential benefits and risks for entering the study.
Riley Ashley
NPRU Graduate
Learn more
To learn more about the Duke Intensive Care Nursery, visit the Duke Division of Neonatology website. For more information about the Neonatal Perinatal Research Unit or to learn more about our clinical trials, email us at npru@duke.edu, or call 919-681-4913.