Skip to main content

Research

Overview

Research interests in the Division of Pediatric Nephrology are varied and directed to understanding kidney disease in children and improving their care.  

Research Faculty
 

Name
Areas of Special Interest
Eileen Tsai Chambers, MD

Identifying immune biomarkers in kidney transplantation and improving non-adherence/transitional care of adolescents

Annabelle Chua, MD Improvement in the care of children with chronic renal failure through national cooperative studies, such as SCOPE
Rasheed Gbadegesin, MD Molecular genetics of nephrotic syndrome and other glomerular disease
Shashi Nagaraj, MD, MBBS Identifying genetic causes of renal disease and other undiagnosed disorders through the Undiagnosed Diseases Clinic
Delbert Raye Wigfall, MD Diagnosis and treatment of secondary and inflammatory renal diseases, hypertension and general nephrology; specifically, treatment of childhood hypertension, infections, glomerulonephritis, and secondary disease related to sickle cell anemia, and systemic lupus erythematosus

Clinical Research

The Division is actively involved in studying methods to improve the care of patients with chronic kidney disease. Specifically, we are:

  • Reducing the progression of chronic kidney disease by improving its detection and management, particularly by leveraging technology to facilitate engagement and self-management;
  • Elucidating the inter-relationships between kidney disease and cardiovascular disease, which together amplify the risk of death;
  • Improving the evidence in nephrology through comparative effectiveness research, including clinical trials, observational studies, and meta-analyses.
  • Promoting more optimal clinical health policy for all patients with kidney disease.
  • Improving the process of transitioning adolescents with kidney disease from pediatricians to internal medicine physicians, i.e., we are involved in developing tools to smooth this transition and improve the outcome.
  • Actively involved in multicenter clinical trials of new treatments of hypertension and renal disease in children and adolescents. 
  • Participating in national cooperative studies optimizing the care of children with chronic renal disease.

Basic Research

Basic research is being conducted to:

  • Identify genetic abnormalities in children with nephrotic syndrome, especially those who are resistant to steroid treatment. Identifying these genetic disorders will increase our understanding of the pathophysiology of nephrotic syndrome and the normal functioning of the glomerular filtration barrier. Ultimately, this research will lead to new methods of treatment.

Clinical Trials

For further information about clinical trials currently being conducted in the Division of Nephrology, please visit dukechildrens.org.