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Priya Sunil Kishnani, MBBS

Chen Family Distinguished Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Medical Genetics
Professor in the Department of Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member in the Duke Clinical Research Institute
Campus mail: 905 Lasalle Street, GSRB1, 4th Floor, Room 4010, Durham, NC 27710
Phone: (919) 681-9854
Email address: kishn001@mc.duke.edu

RESEARCH INTERESTS

A multidisciplinary approach to care of individuals with genetic disorders in conjunction with clinical and bench research that contributes to:
1) An understanding of the natural history and delineation of long term complications of genetic disorders
2) The development of new therapies for genetic disorders through translational research
3) The development and execution of large multicenter trials to confirm safety and efficacy of potential therapies
4) Role of antibodies/immune response in patients on therapeutic proteins.

. Down syndrome: The Duke Comprehensive Down syndrome (DS) clinic is a multidisciplinary clinic for the clinical care of approximately 700 children and young adults with Down syndrome. Research interests include establishing best practices for screening of celiac disease, thyroid dysfunction, and iron deficiency anemia. The Duke DS Research Team is evaluating the effects of cholinesterase inhibitors on cognition and behavior in children and young adults with Down syndrome. Research issues focus on establishing a standard dosing regimen and developing a sensitive and specific test battery to detect changes in language and cognitive ability. These studies are being performed at the Duke Clinical Research Unit at Duke. We are currently involved in a multi-center Phase 2 pediatric trial using donepezil, a cholinesterase inhibitor. The Duke DS Research team is also exploring how a national Down Syndrome registry program could be built and utilized to expand understanding of the condition.

. Lysosomal Storage Disease: The Duke Lysosomal Storage Disease (LSD) treatment center follows and treats patients with Pompe, Gaucher, Fabry, Mucopolysaccharidosis and other LSD's. The Duke Metabolism Clinical Research Team is exploring many aspects of enzyme replacement therapy (ERT), including impact on different systems, differential response, and long term effects. Other symptomatic and treatment interventions for this category of diseases are also being explored in the context of clinical care. The care team has extensive experience in the care of infants and adults with Pompe disease and was instrumental in conducting clinical trials and the bench to bedside work that led to the 2006 FDA approval of alglucosidase alfa, the first treatment for this devastating disease. We are currently focusing on role of antibodies/immune response on patient outcome and role of immunemodulation/immunesuppression as an adjunct to ERT.

. Glycogen Storage Disease: We are actively following subjects with all types of Glycogen Storage Disease, with particular emphasis on types I, II, III, IV, VI and IX. The goal of the treatment team is to better determine the clinical phenotype and long term complications of these diseases. Attention to disease manifestations observed in adulthood, such as adenomas and risk for HCC, is of paramount importance in monitoring and treating these chronic illnesses. We are establishing clinical algorithms for managing adenomas, and the overall management of these patients including cardiac, bone, muscle and liver issues.

. Neuromuscular disorders: We are collaborating with neurologists, cardiologists and neuromuscular physicians to serve as a treatment site for clinical trials in these diseases. We are currently involved in trials of DMD and are working closely on setting up collaborations for studies in SMA.

Education and Training

  • M.B.B.S., University of Bombay, St. Xavier College, 1985

Selected Grants and Awards

Publications

Kishnani, P. S., A. Boney, and Y. T. Chen. “Nutritional deficiencies in a patient with glycogen storage disease type Ib.” J Inherit Metab Dis 22, no. 7 (October 1999): 795–801. https://doi.org/10.1023/a:1005549823146.

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Kishnani, P. S., J. A. Sullivan, B. K. Walter, G. A. Spiridigliozzi, P. M. Doraiswamy, and K. R. Krishnan. “Cholinergic therapy for Down's syndrome.” Lancet 353, no. 9158 (March 27, 1999): 1064–65. https://doi.org/10.1016/S0140-6736(98)05285-4.

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Kishnani, P. S., Y. Bao, J. Y. Wu, A. E. Brix, J. L. Lin, and Y. T. Chen. “Isolation and nucleotide sequence of canine glucose-6-phosphatase mRNA: identification of mutation in puppies with glycogen storage disease type Ia.” Biochem Mol Med 61, no. 2 (August 1997): 168–77. https://doi.org/10.1006/bmme.1997.2600.

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Kishnani, P. S., J. L. Van Hove, J. S. Shoffner, A. Kaufman, E. H. Bossen, and S. G. Kahler. “Acute pancreatitis in an infant with lactic acidosis and a mutation at nucleotide 3243 in the mitochondrial DNA tRNALeu(UUR) gene.” Eur J Pediatr 155, no. 10 (October 1996): 898–903. https://doi.org/10.1007/bf02282842.

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Wang, M., P. Kishnani, M. Decker-Phillips, S. G. Kahler, Y. T. Chen, and M. Godfrey. “Double mutant fibrillin-1 (FBN1) allele in a patient with neonatal Marfan syndrome.” J Med Genet 33, no. 9 (September 1996): 760–63. https://doi.org/10.1136/jmg.33.9.760.

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Bao, Y., P. Kishnani, J. Y. Wu, and Y. T. Chen. “Hepatic and neuromuscular forms of glycogen storage disease type IV caused by mutations in the same glycogen-branching enzyme gene.” J Clin Invest 97, no. 4 (February 15, 1996): 941–48. https://doi.org/10.1172/JCI118517.

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McConkie-Rosell, A., C. Wilson, D. A. Piccoli, J. Boyle, T. DeClue, P. Kishnani, J. J. Shen, A. Boney, B. Brown, and Y. T. Chen. “Clinical and laboratory findings in four patients with the non-progressive hepatic form of type IV glycogen storage disease.” J Inherit Metab Dis 19, no. 1 (1996): 51–58. https://doi.org/10.1007/bf01799348.

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Kishnani, P., A. R. Bengur, and Y. T. Chen. “Pulmonary hypertension in glycogen storage disease type I.” J Inherit Metab Dis 19, no. 2 (1996): 213–16. https://doi.org/10.1007/bf01799432.

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Van Hove, J. L., P. Kishnani, J. Muenzer, R. J. Wenstrup, M. L. Summar, M. R. Brummond, A. M. Lachiewicz, D. S. Millington, and S. G. Kahler. “Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia.” Am J Med Genet 59, no. 4 (December 4, 1995): 444–53. https://doi.org/10.1002/ajmg.1320590410.

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Kishnani, P., A. K. Iafolla, A. McConkie-Rosell, J. L. Van Hove, R. J. Kanter, and S. G. Kahler. “Hemangioma, supraumbilical midline raphé, and coarctation of the aorta with a right aortic arch: single causal entity?” Am J Med Genet 59, no. 1 (October 23, 1995): 44–48. https://doi.org/10.1002/ajmg.1320590110.

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