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Research

Overview

The Division of Pediatric Rheumatology is actively engaged in clinical research to improve the care of children with rheumatic disease. This includes research studies funded by the NIH and foundations, as well as industry.  We currently have active clinical trials in systemic juvenile arthritis, polyarticular juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, pediatric scleroderma, inflammatory eye disease, and drug safety.

Research Faculty

Name
Areas of Special Interest
Egla C. Rabinovich, MD
 
Treatment of childhood rheumatic diseases, treatment of inflammatory eye disease, drug safety, childhood osteoporosis, treatment of juvenile dermatomyositis, classification and treatment of linear scleroderma
Stephen Joseph Balevic, MD Precision medicine, clinical pharmacology, and drug trials
Mara Becker, MD, MSCE Variability in drug response, mainly involving methotrexate and the impact on folate homeostasis in juvenile idiopathic arthritis (JIA) patients
Jeffrey Dvergsten, MD Pathogenesis of pediatric inflammatory diseases
Ann M. Reed, MD Genetics and cause of human autoimmune disease; development of new biomarkers of disease to identify those predisposed to develop disease, as well as monitor disease activity and response to treatment
Rebecca Eli Sadun, MD, PhD Determining how B cell dysfunction leads to lupus, examining transition outcomes in adolescent and young adults with rheumatic diseases, and evaluating the efficiency of curricula aimed at teaching residents and fellows how to help adolescents and young adults transition from pediatric care to adult care
Pediatric rheumatology workforce, cost-effective treatments in rheumatic disease, systemic onset juvenile arthritis, localized scleroderma

Clinical Research

  • Childhood Arthritis and Rheumatology Research Alliance Registry (CARRA)
  • STRIVE: A registry for children with moderate to severe Polyarticular Juvenile Idiopathic Arthritis currently taking the medication HUMIRA
  • Urinary HER2 as a biomarker for Lupus Nephritis
  • Juvenile Dermatomyositis Repository (JDMS Repository)
  • Go VIVA: Trial of IV golimumab (SIMPONI) in patients with active Polyarticular Juvenile Idiopathic Arthritis despite methotrexate therapy
  • Jigsaw: Study to investigate the effectiveness and safety of subcutaneous injection of tocilizumab in patients with Systemic Juvenile Idiopathic Arthritis

Translational Research

  • Nitric oxide metabolism in statin treated pediatric systemic lupus erythematosus
  • Microarray assessment in childhood lupus erythematosus
  • Endothelial progenitor cells in pediatric SLE and atherosclerosis

Clinical Trials

For further information about clinical trials currently being conducted in the Division of Rheumatology, please visit dukechildrens.org.