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Research

The faculty and fellows in the Division of Pediatric Cardiology have a wide variety of research interests in clinical, translational, and basic investigation related to childhood heart disease. 

Research Faculty
 

Name
Areas of Special Interest
Piers Barker, MD Fetal cardiology, cardiac imaging (echo, MRI)
Richard Justin Boruta, MD Cardiac imaging, management of feeding and growth following surgery for congenital heart disease
Cardiac imaging (echo), quality improvement
Cardiac imaging (echo, MRI)
Michael P. Carboni, MD Arrhythmias, heart failure/transplantation, multicenter heart failure and transplant studies including PUMPkin network (mechanical cardiac assist devices for children)
Gregory A. Fleming, MD, MSCI
 
Assessment and development of interventional therapies for children with congenital heart disease, perioperative management of infants and children with congenital heart disease requiring surgery
Heather T. Henderson, MD Multicenter heart failure and transplant studies including PUMPkin network (mechanical cardiac assist devices for children)
Kevin D. Hill, MD, MS Outcomes, drug and device trials, short and long term safety and efficacy of interventions and hemodynamic effects of interventions
Arrhythmias
Sonya Kirmani, MD Hypertrophic and restrictive cardiomyopathy
Andrew Paul Landstrom, MD, PhD Genetic and molecular mechanisms of sudden cardiac arrest in children
Jennifer Li, MD, MHS Hypertension, thrombosis, heart failure clinical trials
Andrew Walker McCrary, MD Non-invasive assessment of cardiac function in fetal to adult patients with congenital heart disease
Angelo Milazzo, MD Fetal cardiology, cardiac imaging (echo)
Stephen Gary Miller, MD  Fetal cardiology, cardiac imaging (echo)
Zebulon Zachary Spector, MD Pediatric and congenital electrophysiology
Gregory Howard Tatum, MD Maternal infant bonding in newborn period after prenatal diagnosis of congenital heart disease; qualitative measures of right ventricular function by echocardiography; assessment of pulmonary hypertension by echocardiography; echocardiographic predictors of acute cellular rejection after heart transplantation
Rachel Diane Torok, MD Pediatric cardiovascular drug development; molecular mechanisms of thoracic aortic aneurysms

Clinical Research

Participation in trials conducted by the Pediatric Heart Network funded by the National Heart, Lung, and Blood Institute:

  • Hypoplastic left heart syndrome
  • Kawasaki disease
  • Cardiomyopathy
  • Marfan syndrome
  • Atrioventricular canal
  • Fontan​

Other clinical trials

  • RSV vaccines
  • Hypertension
  • Heart failure
  • Thrombosis
  • Supraventricular tachycardia

Cardiac imaging

  • 3D echo
  • Torsion
  • Strain-rate
  • MRI

Assessment of various devices to repair congenital cardiac lesions

  • Atrial septal defect/patent foramen ovale (device occluder)
  • Ventricularr septal defect (device occluder)
  • Coarctation of the aorta (stents)
  • Cutting balloon for relief of pulmonary artery obstruction
  • Percutaneous pulmonary valve

Outcomes assessment following

  • Congenital heart surgery
  • Radiofrequency ablation
  • Heart transplantation
  • Implantable Cardioverter Defibrillator (ICD)

Translational/Basic Research

  • Stability of Cardiac Response to Pacing
    Study of the complex and nonlinear response of the cardiac electrical system to rapid pacing in order to understand and potentially prevent the transition from a stable to an unstable cardiac rhythm utilizing multifaceted experimental and theoretical methods to drive the development of computer models.

Fellow Research

Current and recent fellows have worked on the following projects:

  • Glycogen Storage Disease/Pompe Disease clinical trials
  • Outcomes of children undergoing surgery in the Society of Thoracic Surgery Congenital Heart Database
  • Pediatric hypertension clinical trials
  • Endothelial signaling pathways that regulate angiogenesis and vascular remodeling
  • Doppler assessment of mesenteric artery flow in Sano vs. BT shunts in HLHS

Clinical Trials

Jennifer Li, MD, Chief of Pediatric Cardiology Research, has several research interests including pediatric hypertension and hyperlipidemia, heart failure in patients with congenital heart disease, thrombosis in patients with congenital heart disease, and enzyme replacement in Pompe disease.
 
For further information about clinical trials currently being conducted in the Division of Cardiology, please visit Dukechildrens.org.