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Pinar Gumus Balikcioglu, MD

Assistant Professor of Pediatrics
Campus mail: 3000 Erwin Road, Suite 200, Durham, NC 27710
Phone: (919) 668-4002
Email address: pinar.gumus@duke.edu

I have a research interest in the pathogenesis and predictors of progression to Type 2 diabetes in children and adolescents. I examined the relationship between insulin secretion and GAD65 antibody levels at diagnosis on glycemic control in Type 2 Diabetes. I then explored the relationship between body mass index and GAD65 antibody status on β-cell secretion at diabetes onset in African-American children. I subsequently demonstrated that type 2 diabetes in children is associated with abnormalities in cortisol metabolism.

Type 2 diabetes is disproportionately high among African Americans and Hispanic populations and is more common in adolescent females than males despite comparable BMI-z scores. My colleagues and I have explored these differences in a recent analysis of obese adolescents. Using metabolomic profiling, principal components analysis, and regression analysis, we found associations between insulin resistance and a branched chain amino acid-related metabolic signature as well as striking sex dependent differences in metabolic profiles. Our findings are the first to underscore the role of sex differences in metabolic function and outcomes in pediatric obesity. Collectively, my studies have identified strong associations between insulin resistance, cortisol metabolism, and sex steroid action.

I would like to explore if changes in cortisol metabolism and the sex differences in metabolic function is a cause or a consequence of obesity; and if these metabolic findings can predict the development of insulin resistance and type 2 diabetes.

 

 

Education and Training

  • Pediatric Residency, Pediatrics, University of North Carolina at Chapel Hill School of Medicine, 2011 - 2013
  • Fellowship in Pediatric Endocrinology, Pediatrics, Louisiana State University School of Medicine in New Orleans, 2008 - 2011
  • Pediatric Chief Residency, Pediatrics, Hacettepe University (Turkey), 2006 - 2008
  • Pediatric Residency, Pediatrics, Hacettepe University (Turkey), 2002 - 2006
  • M.D., Hacettepe University (Turkey), 2001

Publications

Gumus Balikcioglu, Pinar, Metin Balikcioglu, Michael J. Muehlbauer, Jonathan Q. Purnell, David Broadhurst, Michael Freemark, and Andrea M. Haqq. “Macronutrient Regulation of Ghrelin and Peptide YY in Pediatric Obesity and Prader-Willi Syndrome.” J Clin Endocrinol Metab 100, no. 10 (October 2015): 3822–31. https://doi.org/10.1210/jc.2015-2503.

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Newbern, Dorothee, Pinar Gumus Balikcioglu, Metin Balikcioglu, James Bain, Michael Muehlbauer, Robert Stevens, Olga Ilkayeva, et al. “Sex differences in biomarkers associated with insulin resistance in obese adolescents: metabolomic profiling and principal components analysis.” J Clin Endocrinol Metab 99, no. 12 (December 2014): 4730–39. https://doi.org/10.1210/jc.2014-2080.

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Mason, K., L. Page, and P. Gumus Balikcioglu. “Screening for Hormonal, Monogenic, and Syndromic Disorders in Obese Infants and Children.” Pediatric Annals 43, no. 9 (August 1, 2014): e218–24. https://doi.org/10.3928/00904481-20140825-08.

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Balikcioglu, Pinar Gumus, Ricardo Gómez, Alfonso Vargas, Swaroop Aradhya, Ludwine M. Messiaen, and Yves Lacassie. “Adrenal hypoplasia congenita with phenotypic features suggestive of neurofibromatosis type 1 among three African-American brothers.” Am J Med Genet A 161A, no. 8 (August 2013): 2105–7. https://doi.org/10.1002/ajmg.a.36031.

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Balikcioglu, Pinar Gumus, Metin Balikcioglu, Ricardo Gómez, Alfonso Vargas, and Stuart A. Chalew. “Relationship of body mass index and GAD65 antibody status on β-cell secretion at diabetes onset in African-American children.” J Pediatr Endocrinol Metab 26, no. 11–12 (2013): 1087–91. https://doi.org/10.1515/jpem-2013-0138.

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Gumus, Pinar, and Stuart Chalew. “Not ready for prime time.” J Pediatr Endocrinol Metab 24, no. 1–2 (2011): 5–6. https://doi.org/10.1515/jpem.2011.074.

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Gumus, P., M. Luquette, M. L. Haymon, E. Valerie, J. Morales, and A. Vargas. “Virilizing adrenocortical adenoma associated with acquired anhydrosis in an adolescent girl.” J Pediatr Endocr Met 24, no. 3–4 (2011): 233–35.

Scholars@Duke

Gumus, Pinar, Mark Luquette, Marie Louise Haymon, Evans Valerie, Jaime Morales, and Alfonso Vargas. “Virilizing para-adrenocortical adenoma associated with idiopathic-acquired generalized anhidrosis in an adolescent girl.” J Pediatr Endocrinol Metab 24, no. 3–4 (2011): 233–35. https://doi.org/10.1515/jpem.2011.124.

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Gumus, Pinar, Ricardo Gomez, Alfonso Vargas, and Stuart Chalew. “The relationship of insulin secretion and GAD65 antibody levels at diagnosis on glycemic control in type 2 diabetes.” J Pediatr Endocrinol Metab 23, no. 10 (October 2010): 1025–29. https://doi.org/10.1515/jpem.2010.163.

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Teksam, Ozlem, Pinar Gumus, Benan Bayrakci, Ilkay Erdogan, and Gulsev Kale. “Acute cardiac effects of carbon monoxide poisoning in children.” Eur J Emerg Med 17, no. 4 (August 2010): 192–96. https://doi.org/10.1097/MEJ.0b013e328320ad48.

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