Skip to main content

Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Parikh, S. H., A. Mendizabal, B. Betz-Stablein, P. L. Martin, P. Szabolcs, V. K. Prasad, T. A. Driscoll, and J. Kurtzberg. “Outcomes of Unrelated Umbilical Cord Blood Transplantation In Pediatric Patients With Primary and Secondary Myelodysplastic Syndromes.” In Biology of Blood and Marrow Transplantation, 15:72–72. Elsevier BV, 2009. https://doi.org/10.1016/j.bbmt.2008.12.225.

Full Text

Hwang, E. I., M. G. W. Camitta, R. Vinesett, A. Mendizabal, S. Wood, D. Semmel, K. Page, et al. “Pericardial Effusion Following Unrelated Umbilical Cord Blood Transplantation: Analysis in a Cohort Of 423 Pediatric Patients Transplanted at a Single Center.” In Biology of Blood and Marrow Transplantation, 15:73–74. Elsevier BV, 2009. https://doi.org/10.1016/j.bbmt.2008.12.228.

Full Text

Prasad, V. K., A. Mendizabal, P. Gill, S. H. Parikh, P. Szabolcs, T. A. Driscoll, K. Page, et al. “Unrelated Umbilical Cord Blood Transplantation From A Single 4/6 Matched Unit is an Effective Therapy for Children With Malignant and Non-Malignant Diagnoses: Good Survival, Low Graft Failure and Graft-vs-Host Disease in a Single Center Analysis of 314 Patients.” In Biology of Blood and Marrow Transplantation, 15:27–27. Elsevier BV, 2009. https://doi.org/10.1016/j.bbmt.2008.12.080.

Full Text

Sun, J. M., T. Driscoll, V. K. Prasad, S. Parikh, P. Szabolcs, J. Kurtzberg, and P. L. Martin. “Unrelated Umbilical Cord Blood Transplantation is an Effective Therapy for Wiskott-Aldrich Syndrome.” Biology of Blood and Marrow Transplantation 15, no. 2 (February 2009): 76–76. https://doi.org/10.1016/j.bbmt.2008.12.234.

Full Text

Prasad, Vinod K., Premjit Gill, Richard Vinesett, Suhag H. Parikh, Paul Szabolcs, Timothy A. Driscoll, Kristin M. Page, et al. “Single Donor 4/6 Matched Banked Unrelated Cord Blood Is An Effective Graft Source for Children Undergoing Myeloablative Transplantation for Malignant and Nonmalignant Disorders: Single Center Analysis of 318 Patients.” In Blood, 112:690–690. AMER SOC HEMATOLOGY, 2008.

Scholars@Duke

Page, Kristin M., Adam M. Mendizabal, Vinod K. Prasad, Paul L. Martin, Suhag Parikh, Susan Wood, Gregory D. Sempowski, Paul Szabolcs, and Joanne Kurtzberg. “Posttransplant autoimmune hemolytic anemia and other autoimmune cytopenias are increased in very young infants undergoing unrelated donor umbilical cord blood transplantation..” Biol Blood Marrow Transplant 14, no. 10 (October 2008): 1108–17. https://doi.org/10.1016/j.bbmt.2008.07.006.

Full Text

Prasad, Vinod K., Adam Mendizabal, Suhag H. Parikh, Paul Szabolcs, Timothy A. Driscoll, Kristin Page, Sonali Lakshminarayanan, et al. “Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes..” Blood 112, no. 7 (October 1, 2008): 2979–89. https://doi.org/10.1182/blood-2008-03-140830.

Full Text

Borowitz, Michael J., Meenakshi Devidas, Stephen P. Hunger, W Paul Bowman, Andrew J. Carroll, William L. Carroll, Stephen Linda, et al. “Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study..” Blood 111, no. 12 (June 15, 2008): 5477–85. https://doi.org/10.1182/blood-2008-01-132837.

Full Text

Maloney, K., W. L. Carroll, A. Carroll, M. Devidas, S. P. Hunger, P. L. Martin, C. L. Willman, N. Winick, J. Whitlock, and B. M. Camitta. “Comparison of the biology of Down syndrome (DS) acute lymphoblastic leukemia (ALL) and non-DS ALL: Children's Oncology Group (COG) study P9900..” J Clin Oncol 26, no. 15_suppl (May 20, 2008).

Scholars@Duke

Maloney, K., W. L. Carroll, A. Carroll, M. Devidas, S. P. Hunger, P. L. Martin, C. L. Willman, N. Winick, J. Whitlock, and B. M. Camitta. “Comparison of the biology of Down syndrome (DS) acute lymphoblastic leukemia (ALL) and non-DS ALL: Children’s Oncology Group (COG) study P9900.” Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 10003–10003. https://doi.org/10.1200/jco.2008.26.15_suppl.10003.

Full Text

Pages