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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.  

For most of my time at Duke I have concentrated on providing high quality care for high risk leukemia patients who require high intensity therapies, such as stem cell transplant and immunotherapy.  As a member of the Pediatric Transplant and Cellular Therapy Division I provide clinical care for these patients.  As a member of various cooperative groups and local PI for several drug trials, I have worked to provide better care and more specific therapies for the toxicities associated with stem cell transplant.  

I have also collaborated with the Pediatric Immunology Division to provide a life-saving therapy for a small group of patients with thymic dysfunction, which causes severe immunodeficiency.  Our clinical team now provides support during these patients hospital admissions for donor thymus tissue implantation.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Allewelt, Heather B., Paul L. Martin, Vinod K. Prasad, Kristin Page, and Joanne Kurtzberg. “Late Effects in Infants and Young Children Following Umbilical Cord Blood Transplant Using Busulfan-Based, Myeloablative Non-TBI Conditioning Regimens.” In Biology of Blood and Marrow Transplantation, 20:S63–S63. Elsevier BV, 2014. https://doi.org/10.1016/j.bbmt.2013.12.071.

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McFarren, Alicia, Kristin Page, Suhag Parikh, Paul L. Martin, Timothy A. Driscoll, Joanne Kurtzberg, and Vinod K. Prasad. “Unrelated Umbilical Cord Blood Transplant for Diamond-Blackfan Anemia.” In Biology of Blood and Marrow Transplantation, 20:S177–S177. Elsevier BV, 2014. https://doi.org/10.1016/j.bbmt.2013.12.288.

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Parikh, S. H., A. Mendizabal, C. L. Benjamin, K. V. Komanduri, J. Antony, A. Petrovic, G. Hale, et al. “A novel reduced-intensity conditioning regimen for unrelated umbilical cord blood transplantation in children with nonmalignant diseases.” Biology of Blood and Marrow Transplantation 20, no. 3 (2014): 326–36.

Scholars@Duke

Xu, Heng, Wenjian Yang, Virginia Perez-Andreu, Meenakshi Devidas, Yiping Fan, Cheng Cheng, Deqing Pei, et al. “Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.” J Natl Cancer Inst 105, no. 10 (May 15, 2013): 733–42. https://doi.org/10.1093/jnci/djt042.

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Boelens, Jaap Jan, Mieke Aldenhoven, Duncan Purtill, Annalisa Ruggeri, Todd Defor, Robert Wynn, Ed Wraith, et al. “Outcomes of transplantation using various hematopoietic cell sources in children with Hurler syndrome after myeloablative conditioning.” Blood 121, no. 19 (May 9, 2013): 3981–87. https://doi.org/10.1182/blood-2012-09-455238.

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Ramsey, Laura B., John C. Panetta, Colton Smith, Wenjian Yang, Yiping Fan, Naomi J. Winick, Paul L. Martin, et al. “Genome-wide study of methotrexate clearance replicates SLCO1B1.” Blood 121, no. 6 (February 7, 2013): 898–904. https://doi.org/10.1182/blood-2012-08-452839.

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Ramsey, Laura B., John C. Panetta, Colton Smith, Wenjian Yang, Yiping Fan, Naomi Winick, Paul L. Martin, et al. “A Genome-Wide Analysis of Variants Influencing Methotrexate Clearance Replicates SLCO1B1.” In Blood, 120:2466–2466. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.2466.2466.

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Yang, Jun J., Heng Xu, Wenjian Yang, Virginia Perez-Andreu, Meenakshi Devidas, Yiping Fan, Cheng Cheng, et al. “Genome-Wide Association Study Identifies a Novel Susceptibility Locus At 10p12.31-12.2 for Childhood Acute Lymphoblastic Leukemia in Ethinically Diverse Populations.” In Blood, 120:877–877. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.877.877.

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Yang, Jun J., Cheng Cheng, Devidas Meenakshi, Xueyuan Cao, Dario Campana, Wenjian Yang, Yiping Fan, et al. “Genome-Wide Association Study Identifies Germline Polymorphisms Associated with Relapse of Childhood Acute Lymphoblastic Leukemia.” In Blood, 120:878–878. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.878.878.

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Richardson, Paul G., Angela Smith, Nancy A. Kernan, Stephan A. Grupp, Sally Arai, Brandon M. Triplett, Paul R. Haut, et al. “Results of a Large Prospective Study On the Use of Defibrotide (DF) in the Treatment of Hepatic Veno-Occlusive Disease (VOD) in Hematopoietic Stem Cell Transplant (HSCT). Early Intervention Improves Outcome – Updated Results of a Treatment IND (T-IND) Expanded Access Protocol.” In Blood, 120:738–738. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.738.738.

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