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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.  

For most of my time at Duke I have concentrated on providing high quality care for high risk leukemia patients who require high intensity therapies, such as stem cell transplant and immunotherapy.  As a member of the Pediatric Transplant and Cellular Therapy Division I provide clinical care for these patients.  As a member of various cooperative groups and local PI for several drug trials, I have worked to provide better care and more specific therapies for the toxicities associated with stem cell transplant.  

I have also collaborated with the Pediatric Immunology Division to provide a life-saving therapy for a small group of patients with thymic dysfunction, which causes severe immunodeficiency.  Our clinical team now provides support during these patients hospital admissions for donor thymus tissue implantation.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Allewelt, Heather, Jill El-Khorazaty, Adam Mendizabal, Mahsa Taskindoust, Paul L. Martin, Vinod Prasad, Kristin Page, Jean Sanders, and Joanne Kurtzberg. “Late Effects after Umbilical Cord Blood Transplantation in Very Young Children after Busulfan-Based, Myeloablative Conditioning.” Biol Blood Marrow Transplant 22, no. 9 (September 2016): 1627–35. https://doi.org/10.1016/j.bbmt.2016.05.024.

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Liu, Chengcheng, Wenjian Yang, Meenakshi Devidas, Cheng Cheng, Deqing Pei, Colton Smith, William L. Carroll, et al. “Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.” J Clin Oncol 34, no. 18 (June 20, 2016): 2133–40. https://doi.org/10.1200/JCO.2015.64.5812.

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Richardson, Paul G., Marcie L. Riches, Nancy A. Kernan, Joel A. Brochstein, Shin Mineishi, Amanda M. Termuhlen, Sally Arai, et al. “Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure.” Blood 127, no. 13 (March 31, 2016): 1656–65. https://doi.org/10.1182/blood-2015-10-676924.

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Richardson, Paul G., Nancy A. Kernan, Joel A. Brochstein, Shin Mineishi, Sally Arai, Stephan A. Grupp, Eva Guinan, et al. “Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome with Multi-Organ Dysfunction: Final Results from a Pivotal, Historically Controlled, Phase 3 Trial.” In Biology of Blood and Marrow Transplantation, 22:S25–S25. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.306.

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Martin, Paul L., Gideon Steinbach, Allen R. Chen, Amrita Krishnan, Nancy A. Kernan, David E. Avigan, Thomas R. Spitzer, and Paul G. Richardson. “1600 Patients for the Treatment of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome.” In Biology of Blood and Marrow Transplantation, 22:S337–38. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.822.

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Allewelt, Heather B., Sachit Patel, Vinod K. Prasad, Joanne Kurtzberg, Timothy A. Driscoll, Paul L. Martin, Kristin Page, and Suhag Parikh. “Umbilical Cord Blood Transplantation for Cartilage Hair Hypoplasia: A Single Center Experience Demonstrates Excellent Outcomes Using Myeloablative Preparative Regimens.” In Biology of Blood and Marrow Transplantation, 22:S235–S235. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.646.

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Patel, Sachit, Heather B. Allewelt, Paul L. Martin, Kristin Page, Timothy A. Driscoll, Vinod K. Prasad, Joanne Kurtzberg, and Suhag Parikh. “Unrelated Umbilical Cord Blood Transplantation for Pediatric Hemophagocytic Lymphohistiocytosis.” In Biology of Blood and Marrow Transplantation, 22:S257–S257. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.686.

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Richardson, Paul G., Marcie Riches, Nancy A. Kernan, Joel A. Brochstein, Shin Mineishi, Amanda M. Termuhlen, Sally Arai, et al. “Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome with Multi-Organ Dysfunction: Final Results from a Pivotal, Historically Controlled, Phase 3 Trial.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.

Scholars@Duke

Moriyama, Takaya, Monika L. Metzger, Gang Wu, Rina Nishii, Maoxiang Qian, Meenakshi Devidas, Wenjian Yang, et al. “Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study.” Lancet Oncol 16, no. 16 (December 2015): 1659–66. https://doi.org/10.1016/S1470-2045(15)00369-1.

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Allewelt, Heather, Paul L. Martin, Paul Szabolcs, Nelson Chao, Rebecca Buckley, and Suhag Parikh. “Hematopoietic Stem Cell Transplantation for CD40 Ligand Deficiency: Single Institution Experience.” Pediatr Blood Cancer 62, no. 12 (December 2015): 2216–22. https://doi.org/10.1002/pbc.25711.

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