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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Grupp, Stephan A., Theodore W. Laetsch, Jochen Buechner, Henrique Bittencourt, Shannon L. Maude, Michael R. Verneris, Gary D. Myers, et al. “Analysis of a Global Registration Trial of the Efficacy and Safety of CTL019 in Pediatric and Young Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL).” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.

Scholars@Duke

Parikh, Suhag H., Joel Brochstein, Paul L. Martin, Mitchell E. Horwitz, Einat Galamidi, Iddo Peleg, Uri Goshen, et al. “Successful Engraftment of Donor Umbilical Cord Blood (UCB) Cells after Co-Transplantation of Nicord (R) (Ex Vivo Expanded UCB Progenitor Cells with Nicotinamide) and a Second Unmanipulated Cord Blood Unit after Myeloablative Chemotherapy in Pediatric Patients with Severe Sickle Cell Disease.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.

Scholars@Duke

Sayour, Elias J., Talal Mousallem, David Van Mater, Endi Wang, Paul Martin, Rebecca H. Buckley, and Raymond C. Barfield. “Bone marrow transplantation for CVID-like humoral immune deficiency associated with red cell aplasia..” Pediatr Blood Cancer 63, no. 10 (October 2016): 1856–59. https://doi.org/10.1002/pbc.26092.

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Allewelt, Heather, Jill El-Khorazaty, Adam Mendizabal, Mahsa Taskindoust, Paul L. Martin, Vinod Prasad, Kristin Page, Jean Sanders, and Joanne Kurtzberg. “Late Effects after Umbilical Cord Blood Transplantation in Very Young Children after Busulfan-Based, Myeloablative Conditioning..” Biol Blood Marrow Transplant 22, no. 9 (September 2016): 1627–35. https://doi.org/10.1016/j.bbmt.2016.05.024.

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Liu, Chengcheng, Wenjian Yang, Meenakshi Devidas, Cheng Cheng, Deqing Pei, Colton Smith, William L. Carroll, et al. “Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia..” J Clin Oncol 34, no. 18 (June 20, 2016): 2133–40. https://doi.org/10.1200/JCO.2015.64.5812.

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Richardson, Paul G., Marcie L. Riches, Nancy A. Kernan, Joel A. Brochstein, Shin Mineishi, Amanda M. Termuhlen, Sally Arai, et al. “Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure..” Blood 127, no. 13 (March 31, 2016): 1656–65. https://doi.org/10.1182/blood-2015-10-676924.

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Richardson, Paul G., Nancy A. Kernan, Joel A. Brochstein, Shin Mineishi, Sally Arai, Stephan A. Grupp, Eva Guinan, et al. “Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome with Multi-Organ Dysfunction: Final Results from a Pivotal, Historically Controlled, Phase 3 Trial.” In Biology of Blood and Marrow Transplantation, 22:S25–S25. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.306.

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Martin, Paul L., Gideon Steinbach, Allen R. Chen, Amrita Krishnan, Nancy A. Kernan, David E. Avigan, Thomas R. Spitzer, and Paul G. Richardson. “1600 Patients for the Treatment of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome.” In Biology of Blood and Marrow Transplantation, 22:S337–38. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.822.

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Allewelt, Heather B., Sachit Patel, Vinod K. Prasad, Joanne Kurtzberg, Timothy A. Driscoll, Paul L. Martin, Kristin Page, and Suhag Parikh. “Umbilical Cord Blood Transplantation for Cartilage Hair Hypoplasia: A Single Center Experience Demonstrates Excellent Outcomes Using Myeloablative Preparative Regimens.” In Biology of Blood and Marrow Transplantation, 22:S235–S235. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.646.

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Patel, Sachit, Heather B. Allewelt, Paul L. Martin, Kristin Page, Timothy A. Driscoll, Vinod K. Prasad, Joanne Kurtzberg, and Suhag Parikh. “Unrelated Umbilical Cord Blood Transplantation for Pediatric Hemophagocytic Lymphohistiocytosis.” In Biology of Blood and Marrow Transplantation, 22:S257–S257. Elsevier BV, 2016. https://doi.org/10.1016/j.bbmt.2015.11.686.

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