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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.  

For most of my time at Duke I have concentrated on providing high quality care for high risk leukemia patients who require high intensity therapies, such as stem cell transplant and immunotherapy.  As a member of the Pediatric Transplant and Cellular Therapy Division I provide clinical care for these patients.  As a member of various cooperative groups and local PI for several drug trials, I have worked to provide better care and more specific therapies for the toxicities associated with stem cell transplant.  

I have also collaborated with the Pediatric Immunology Division to provide a life-saving therapy for a small group of patients with thymic dysfunction, which causes severe immunodeficiency.  Our clinical team now provides support during these patients hospital admissions for donor thymus tissue implantation.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Martin, P. L., M. Lacaze, T. A. Driscoll, P. Szaboles, J. Kurtzberg, J. Wiley, P. Rubinstein, and R. P. Howrey. “Unrelated umbilical cord blood transplant for osteopetrosis.” Blood 96, no. 11 (November 16, 2000): 207A-207A.

Scholars@Duke

Klock, B., T. Pham, L. S. Smith, S. Beris, F. M. Lobo, P. L. Martin, J. Rappeport, and R. L. Fuleihan. “When you hear hoof beats...do not forget the zebras.” Curr Opin Pediatr 12, no. 2 (April 2000): 172–77. https://doi.org/10.1097/00008480-200004000-00016.

Full Text

Kurtzberg, J., P. Martin, N. Chao, C. Stevens, and P. Rubinstein. “Unrelated placental blood in marrow transplantation.” Stem Cells 18, no. 2 (2000): 153–54. https://doi.org/10.1634/stemcells.18-2-153.

Full Text

Kurtzberg, J., J. Jaroscak, P. L. Martin, T. Driscoll, B. Waters-Pick, J. Douville, R. Howrey, K. L. Goltry, and A. K. Smith. “Augmentation of umbilical cord blood (UCB) transplantation with ex vivo expaned cells, a phase I trial using the replicell system.” Blood 94, no. 10 (November 15, 1999): 571A-571A.

Scholars@Duke

Kurtzberg, J., P. Szabolcs, T. Driscoll, R. Howrey, B. Waters-Pick, and P. L. Martin. “Transplantation of a patient with congenital neutropenia and invasive fungal disease with unrelated umbilical cord blood using paternal G-CSF mobilized, irradiated granulocyte support.” Blood 94, no. 10 (November 15, 1999): 368B-369B.

Scholars@Duke

Jaroscak, J., P. L. Martin, B. Waters-Pick, R. D. Armstrong, T. Driscoll, R. P. Howrey, S. Castellino, et al. “A phase I trial of augmentation of unrelated umbilical cord blood transplantation with ex-vivo expanded cells.” Blood 92, no. 10 (November 15, 1998): 646A-646A.

Scholars@Duke

Graham, M. L., E. Katsanis, T. W. Shapiro, J. J. Hutter, P. L. Martin, and J. Kurtzberg. “Busulfan and melphalan as preparative therapy for BMT in childhood leukemias.” Blood 92, no. 10 (November 15, 1998): 128A-128A.

Scholars@Duke

Kurtzberg, J., C. Carrier, P. L. Martin, C. E. Stevens, R. P. Howrey, T. A. Driscoll, N. Reismoen, and P. Rubinstein. “Transient engraftment of maternal T-cells in recipients of unrelated cord blood transplants.” Blood 92, no. 10 (November 15, 1998): 652A-653A.

Scholars@Duke

Martin, P. L., R. Howrey, T. Driscoll, B. Frothingham, W. Owen, P. Kelly, Y. Lee, N. Hamerschlak, and J. Kurtzberg. “Transplantation of related, haplo-identical umbilical cord blood in pediatric patients with genetic hematological diseases.” Blood 92, no. 10 (November 15, 1998): 358B-358B.

Scholars@Duke

Howrey, R. P., P. L. Martin, G. Ciocci, T. A. Driscoll, M. Frey, R. H. Buckley, W. H. Hickling, et al. “Unrelated cord blood transplantation for correction of genetic diseases.” Blood 92, no. 10 (November 15, 1998): 291A-291A.

Scholars@Duke

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