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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Laughlin, M. J., D. A. Rizzieri, C. A. Smith, J. O. Moore, S. Lilly, D. McGaughey, P. Martin, et al. “Hematologic engraftment and reconstitution of immune function post unrelated placental cord blood transplant in an adult with acute lymphocytic leukemia..” Leuk Res 22, no. 3 (March 1998): 215–19. https://doi.org/10.1016/s0145-2126(97)00171-9.

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Martin, P. L., J. Jaroscak, N. Hamerschlak, and J. Kurtzberg. “Correction of beta thalassemia major with umbilical cord blood transplantation from a related haploidentical donor..” Blood 90, no. 10 (November 15, 1997): 4536–4536.

Scholars@Duke

Martin, P. L., J. Thompson, G. Gottesman, J. Reid, M. P. Whyte, C. Miller, and J. Kurtzberg. “Marked radiographic improvement in infantile hypophosphatasia with T-depleted bone marrow transplantation from a related haploidentical donor..” Blood 90, no. 10 (November 15, 1997): 4537–4537.

Scholars@Duke

Martin, P. L., A. T. Look, S. Schnell, M. B. Harris, J. Pullen, J. J. Shuster, A. J. Carroll, M. J. Pettenati, and P. N. Rao. “Comparison of fluorescence in situ hybridization, cytogenetic analysis, and DNA index analysis to detect chromosomes 4 and 10 aneuploidy in pediatric acute lymphoblastic leukemia: a Pediatric Oncology Group study..” J Pediatr Hematol Oncol 18, no. 2 (May 1996): 113–21.

Scholars@Duke

Kilpatrick, S. E., L. A. Teot, K. R. Geisinger, P. L. Martin, D. K. Shumate, N. Zbieranski, G. B. Russell, and C. D. Fletcher. “Relationship of DNA ploidy to histology and prognosis in rhabdomyosarcoma. Comparison of flow cytometry and image analysis..” Cancer 74, no. 12 (December 15, 1994): 3227–33. https://doi.org/10.1002/1097-0142(19941215)74:12<3227::aid-cncr2820741223>3.0.co;2-x.

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Martin, P. L., and J. M. Rappeport. “Bone marrow transplantation in the perinatal period..” Semin Perinatol 14, no. 5 (October 1990): 416–22.

Scholars@Duke

Bieker, J. J., P. L. Martin, and R. G. Roeder. “Formation of a rate-limiting intermediate in 5S RNA gene transcription..” Cell 40, no. 1 (January 1985): 119–27. https://doi.org/10.1016/0092-8674(85)90315-0.

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Lassar, A. B., P. L. Martin, and R. G. Roeder. “Transcription of class III genes: formation of preinitiation complexes..” Science 222, no. 4625 (November 18, 1983): 740–48. https://doi.org/10.1126/science.6356356.

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Dignam, J. D., P. L. Martin, B. S. Shastry, and R. G. Roeder. “Eukaryotic gene transcription with purified components..” Methods Enzymol 101 (1983): 582–98. https://doi.org/10.1016/0076-6879(83)01039-3.

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