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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University, 1987
  • M.D., Washington University, 1987

Publications

Parikh, SH, Pentz, RD, Haight, A, Adeli, M, Martin, PL, Driscoll, TA, Page, K, Kurtzberg, J, Prasad, VK, and Barfield, RC. "Ethical considerations of using a single minor donor for three bone marrow harvests for three HLA-matched siblings with primary immunodeficiency." Pediatric Blood & Cancer 66, no. 4 (April 2019): e27602-null.

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Spees, LP, Martin, PL, Kurtzberg, J, Stokhuyzen, A, McGill, L, Prasad, VK, Driscoll, TA, Parikh, SH, Page, KM, Vinesett, R, Severyn, C, Sung, AD, Proia, AD, Jenkins, K, Arshad, M, Steinbach, WJ, Seed, PC, and Kelly, MS. "Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014)." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 25, no. 4 (April 2019): 756-763.

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Qian, M, Xu, H, Perez-Andreu, V, Roberts, KG, Zhang, H, Yang, W, Zhang, S, Zhao, X, Smith, C, Devidas, M, Gastier-Foster, JM, Raetz, E, Larsen, E, Burchard, EG, Winick, N, Bowman, WP, Martin, PL, Borowitz, M, Wood, B, Antillon-Klussmann, F, Pui, C-H, Mullighan, CG, Evans, WE, Hunger, SP, Relling, MV, Loh, ML, and Yang, JJ. "Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics." Blood 133, no. 7 (February 2019): 724-729.

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Lund, TC, Ahn, KW, Tecca, HR, Hilgers, MV, Abdel-Azim, H, Abraham, A, Diaz, MA, Badawy, SM, Broglie, L, Brown, V, Dvorak, CC, Gonzalez-Vicent, M, Hashem, H, Hayashi, RJ, Jacobsohn, DA, Kent, MW, Li, C-K, Margossian, SP, Martin, PL, Mehta, P, Myers, K, Olsson, R, Page, K, Pulsipher, MA, Shaw, PJ, Smith, AR, Triplett, BM, Verneris, MR, and Eapen, M. "Outcomes after Second Hematopoietic Cell Transplantation in Children and Young Adults with Relapsed Acute Leukemia." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 25, no. 2 (February 2019): 301-306.

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Mahadeo, KM, Khazal, SJ, Abdel-Azim, H, Fitzgerald, JC, Taraseviciute, A, Bollard, CM, Tewari, P, Duncan, C, Traube, C, McCall, D, Steiner, ME, Cheifetz, IM, Lehmann, LE, Mejia, R, Slopis, JM, Bajwa, R, Kebriaei, P, Martin, PL, Moffet, J, McArthur, J, Petropoulos, D, O'Hanlon Curry, J, Featherston, S, Foglesong, J, Shoberu, B, Gulbis, A, Mireles, ME, Hafemeister, L, Nguyen, C, Kapoor, N, Rezvani, K, Neelapu, SS, Shpall, EJ, and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, . "Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy." Nature Reviews. Clinical Oncology 16, no. 1 (January 2019): 45-63. (Review)

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Li, L, Sajdyk, T, Smith, EML, Chang, CW, Li, C, Ho, RH, Hutchinson, R, Wells, E, Skiles, JL, Winick, N, Martin, PL, and Renbarger, JL. "Genetic Variants Associated With Vincristine-Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia." Clinical Pharmacology and Therapeutics (December 3, 2018).

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Huang, S, Martin, P, and Campbell, MJ. "Coronary artery occlusion secondary to graft versus host disease after bone marrow transplant in a 21-year-old." Cardiology in the Young 28, no. 12 (December 2018): 1484-1486.

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Grupp, SA, Maude, SL, Rives, S, Baruchel, A, Boyer, MW, Bittencourt, H, Bader, P, Buchner, J, Laetsch, TW, Stefanski, H, Myers, GD, Qayed, M, Pulsipher, MA, De Moerloose, B, Yanik, GA, Davis, KL, Martin, PL, Nemecek, ER, Peters, C, Krueger, J, Balduzzi, A, Boissel, N, Mechinaud, FM, Leung, M, Eldjerou, LK, Yi, L, Mueller, KT, Bleickardt, E, and Hiramatsu, H. "Updated Analysis of the Efficacy and Safety of Tisagenlecleucel in Pediatric and Young Adult Patients with Relapsed/Refractory (r/r) Acute Lymphoblastic Leukemia." 60th Annual Meeting of the American-Society-of-Hematology (ASH). San Diego, CA. December 1, 2018 - December 4, 2018.: AMER SOC HEMATOLOGY, November 29, 2018.

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Duncan, CN, Brazauskas, R, Huang, J, Shaw, BE, Majhail, NS, Savani, BN, Flowers, MED, Battiwalla, M, Beebe, K, Dietz, AC, Dvorak, CC, Giller, R, Jacobsohn, DA, Kletzel, M, Martin, PL, Nemecek, ER, Nuechterlein, B, Talano, J-A, Pulsipher, MA, and Baker, KS. "Late cardiovascular morbidity and mortality following pediatric allogeneic hematopoietic cell transplantation." Bone Marrow Transplantation 53, no. 10 (October 2018): 1278-1287.

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Jacobsohn, DA, Loken, MR, Fei, M, Adams, A, Brodersen, LE, Logan, BR, Ahn, KW, Shaw, BE, Kletzel, M, Olszewski, M, Khan, S, Meshinchi, S, Keating, A, Harris, A, Teira, P, Duerst, RE, Margossian, SP, Martin, PL, Petrovic, A, Dvorak, CC, Nemecek, ER, Boyer, MW, Chen, AR, Davis, JH, Shenoy, S, Savasan, S, Hudspeth, MP, Adams, RH, Lewis, VA, Kheradpour, A, Kasow, KA, Gillio, AP, Haight, AE, Bhatia, M, Bambach, BJ, Haines, HL, Quigg, TC, Greiner, RJ, Talano, J-AM, Delgado, DC, Cheerva, A, Gowda, M, Ahuja, S, Ozkaynak, M, Mitchell, D, Schultz, KR, Fry, TJ, Loeb, DM, and Pulsipher, MA. "Outcomes of Measurable Residual Disease in Pediatric Acute Myeloid Leukemia before and after Hematopoietic Stem Cell Transplant: Validation of Difference from Normal Flow Cytometry with Chimerism Studies and Wilms Tumor 1 Gene Expression." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 10 (October 2018): 2040-2046.

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