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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Kelly, Matthew S., Doyle V. Ward, Christopher J. Severyn, Mehreen Arshad, Sarah M. Heston, Kirsten Jenkins, Paul L. Martin, et al. “Gut Colonization Preceding Mucosal Barrier Injury Bloodstream Infection in Pediatric Hematopoietic Stem Cell Transplant Recipients..” Biol Blood Marrow Transplant, July 18, 2019. https://doi.org/10.1016/j.bbmt.2019.07.019.

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Li, Lang, Tammy Sajdyk, Ellen M. L. Smith, Chien Wei Chang, Claire Li, Richard H. Ho, Raymond Hutchinson, et al. “Genetic Variants Associated With Vincristine-Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia..” Clin Pharmacol Ther 105, no. 6 (June 2019): 1421–28. https://doi.org/10.1002/cpt.1324.

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Parikh, Suhag H., Rebecca D. Pentz, Ann Haight, Mehdi Adeli, Paul L. Martin, Timothy A. Driscoll, Kristin Page, Joanne Kurtzberg, Vinod K. Prasad, and Raymond C. Barfield. “Ethical considerations of using a single minor donor for three bone marrow harvests for three HLA-matched siblings with primary immunodeficiency..” Pediatr Blood Cancer 66, no. 4 (April 2019). https://doi.org/10.1002/pbc.27602.

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Spees, Lisa P., Paul L. Martin, Joanne Kurtzberg, Andre Stokhuyzen, Lauren McGill, Vinod K. Prasad, Timothy A. Driscoll, et al. “Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014)..” Biol Blood Marrow Transplant 25, no. 4 (April 2019): 756–63. https://doi.org/10.1016/j.bbmt.2018.11.018.

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Qian, Maoxiang, Heng Xu, Virginia Perez-Andreu, Kathryn G. Roberts, Hui Zhang, Wenjian Yang, Shouyue Zhang, et al. “Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics..” Blood 133, no. 7 (February 14, 2019): 724–29. https://doi.org/10.1182/blood-2018-07-862946.

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Lund, Troy C., Kwang Woo Ahn, Heather R. Tecca, Megan V. Hilgers, Hisham Abdel-Azim, Allistair Abraham, Miguel Angel Diaz, et al. “Outcomes after Second Hematopoietic Cell Transplantation in Children and Young Adults with Relapsed Acute Leukemia..” Biol Blood Marrow Transplant 25, no. 2 (February 2019): 301–6. https://doi.org/10.1016/j.bbmt.2018.09.016.

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Mahadeo, Kris M., Sajad J. Khazal, Hisham Abdel-Azim, Julie C. Fitzgerald, Agne Taraseviciute, Catherine M. Bollard, Priti Tewari, et al. “Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy..” Nat Rev Clin Oncol 16, no. 1 (January 2019): 45–63. https://doi.org/10.1038/s41571-018-0075-2.

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Huang, Sihong, Paul Martin, and M Jay Campbell. “Coronary artery occlusion secondary to graft versus host disease after bone marrow transplant in a 21-year-old..” Cardiol Young 28, no. 12 (December 2018): 1484–86. https://doi.org/10.1017/S1047951118001592.

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Grupp, Stephan A., Shannon L. Maude, Susana Rives, Andre Baruchel, Michael W. Boyer, Henrique Bittencourt, Peter Bader, et al. “Updated Analysis of the Efficacy and Safety of Tisagenlecleucel in Pediatric and Young Adult Patients with Relapsed/Refractory (r/r) Acute Lymphoblastic Leukemia.” In Blood, Vol. 132. AMER SOC HEMATOLOGY, 2018. https://doi.org/10.1182/blood-2018-99-112599.

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Duncan, Christine N., Ruta Brazauskas, Jiaxing Huang, Bronwen E. Shaw, Navneet S. Majhail, Bipin N. Savani, Mary E. D. Flowers, et al. “Late cardiovascular morbidity and mortality following pediatric allogeneic hematopoietic cell transplantation..” Bone Marrow Transplant 53, no. 10 (October 2018): 1278–87. https://doi.org/10.1038/s41409-018-0155-z.

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