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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.  

For most of my time at Duke I have concentrated on providing high quality care for high risk leukemia patients who require high intensity therapies, such as stem cell transplant and immunotherapy.  As a member of the Pediatric Transplant and Cellular Therapy Division I provide clinical care for these patients.  As a member of various cooperative groups and local PI for several drug trials, I have worked to provide better care and more specific therapies for the toxicities associated with stem cell transplant.  

I have also collaborated with the Pediatric Immunology Division to provide a life-saving therapy for a small group of patients with thymic dysfunction, which causes severe immunodeficiency.  Our clinical team now provides support during these patients hospital admissions for donor thymus tissue implantation.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Tanaka, John S., Rebecca R. Young, Sarah M. Heston, Kirsten Jenkins, Lisa P. Spees, Anthony D. Sung, Kelly Corbet, et al. “Anaerobic Antibiotics and the Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.” Biol Blood Marrow Transplant, July 17, 2020. https://doi.org/10.1016/j.bbmt.2020.07.011.

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Shah, Nirali N., Deepa Bhojwani, Keith August, André Baruchel, Yves Bertrand, Jessica Boklan, Luciano Dalla-Pozza, et al. “Results from an international phase 2 study of the anti-CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B-lineage acute lymphoblastic leukemia.” Pediatr Blood Cancer 67, no. 5 (May 2020): e28112. https://doi.org/10.1002/pbc.28112.

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Akinboyo, Ibukunoluwa C., Rebecca R. Young, Lisa P. Spees, Sarah M. Heston, Michael J. Smith, Yeh-Chung Chang, Lauren E. McGill, et al. “Microbiology and Risk Factors for Hospital-Associated Bloodstream Infections Among Pediatric Hematopoietic Stem Cell Transplant Recipients.” Open Forum Infect Dis 7, no. 4 (April 2020): ofaa093. https://doi.org/10.1093/ofid/ofaa093.

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Winick, Naomi, Paul L. Martin, Meenakshi Devidas, Jonathan Shuster, Michael J. Borowitz, W. Paul Bowman, Eric Larsen, et al. “Randomized assessment of delayed intensification and two methods for parenteral methotrexate delivery in childhood B-ALL: Children's Oncology Group Studies P9904 and P9905.” Leukemia 34, no. 4 (April 2020): 1006–16. https://doi.org/10.1038/s41375-019-0642-2.

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Robles, Joanna M., Jesse D. Troy, Kristin M. Schroeder, Paul L. Martin, and Thomas W. LeBlanc. “The Effect of Limited-English Proficiency on Hematopoietic Stem Cell Transplantation Outcomes: A Retrospective Cohort Study of Hispanic Pediatric Transplant Patients at a Single Institution.” In Biology of Blood and Marrow Transplantation, 26:S195–96. ELSEVIER SCIENCE INC, 2020.

Scholars@Duke

Shah, N. N., J. Schneiderman, D. Kuruvilla, D. Bhojwani, T. J. Fry, P. L. Martin, K. R. Schultz, et al. “Fatal capillary leak syndrome in a child with acute lymphoblastic leukemia treated with moxetumomab pasudotox for pre-transplant minimal residual disease reduction.” Pediatric Blood and Cancer, January 1, 2020. https://doi.org/10.1002/pbc.28574.

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Kelly, Matthew S., Doyle V. Ward, Christopher J. Severyn, Mehreen Arshad, Sarah M. Heston, Kirsten Jenkins, Paul L. Martin, et al. “Gut Colonization Preceding Mucosal Barrier Injury Bloodstream Infection in Pediatric Hematopoietic Stem Cell Transplantation Recipients.” Biol Blood Marrow Transplant 25, no. 11 (November 2019): 2274–80. https://doi.org/10.1016/j.bbmt.2019.07.019.

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Li, Lang, Tammy Sajdyk, Ellen M. L. Smith, Chien Wei Chang, Claire Li, Richard H. Ho, Raymond Hutchinson, et al. “Genetic Variants Associated With Vincristine-Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia.” Clin Pharmacol Ther 105, no. 6 (June 2019): 1421–28. https://doi.org/10.1002/cpt.1324.

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Parikh, Suhag H., Rebecca D. Pentz, Ann Haight, Mehdi Adeli, Paul L. Martin, Timothy A. Driscoll, Kristin Page, Joanne Kurtzberg, Vinod K. Prasad, and Raymond C. Barfield. “Ethical considerations of using a single minor donor for three bone marrow harvests for three HLA-matched siblings with primary immunodeficiency.” Pediatr Blood Cancer 66, no. 4 (April 2019): e27602. https://doi.org/10.1002/pbc.27602.

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Spees, Lisa P., Paul L. Martin, Joanne Kurtzberg, Andre Stokhuyzen, Lauren McGill, Vinod K. Prasad, Timothy A. Driscoll, et al. “Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014).” Biol Blood Marrow Transplant 25, no. 4 (April 2019): 756–63. https://doi.org/10.1016/j.bbmt.2018.11.018.

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