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Michael Scott Freemark, MD

Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine
Professor of Pediatrics
Chief, Divison of Pediatric Endocrinology
Affiliate, Duke Global Health Institute
Member of Sarah W. Stedman Nutrition and Metabolism Center
Campus mail: Box 102820 Med Ctr, Durham, NC 27710
Phone: (919) 684-8350
Email address: freem001@mc.duke.edu

The primary objective of my basic research has been to elucidate the roles of placental and fetal hormones in the regulation of maternal metabolism and fetal growth. My work has focused on the lactogenic hormones produced by the pituitary gland and placenta. In recent studies we have used targeted knockout mice to explore the molecular mechanisms by which prolactin and placental lactogen regulate pancreatic beta cell mass and insulin production during pregnancy and postnatal life.
I also have a clinical research interest in the pathogenesis and treatment of obesity and hyperlipidemia and the prevention of type 2 diabetes. In previous studies we showed that the drug metformin reduces fat stores and blood glucose and insulin levels in obese adolescents and may reduce the risk of progression to diabetes in selected patients. We have also examined the unique metabolic characteristics of Prader Willi syndrome, a genetic obesity disorder. Finally, we have recently completed a detailed study of metabolism in malnourished children in Uganda and characterized the effects of concurrent HIV infection on nutritional recovery.

Education and Training

  • M.D., Duke University, 1976
  • B.A., Brandeis University, 1972

Selected Grants and Awards

Publications

Freemark, Michael. “Placental hormones and the control of fetal growth..” J Clin Endocrinol Metab 95, no. 5 (May 2010): 2054–57. https://doi.org/10.1210/jc.2010-0517.

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Freemark, M. S. Freemark, Michael S (editor). Pediatric Obesity: Etiology, pathogenesis and treatment. Second Edition. Springer Press, 2010. Edited by M. S. Freemark, 2010.

Scholars@Duke

Haqq, Andrea M., Steven C. Grambow, Michael Muehlbauer, Christopher B. Newgard, Laura P. Svetkey, Aaron L. Carrel, Jack A. Yanovski, Jonathan Q. Purnell, and Michael Freemark. “Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development..” Clin Endocrinol (Oxf) 69, no. 6 (December 2008): 911–20. https://doi.org/10.1111/j.1365-2265.2008.03385.x.

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August, Gilbert P., Sonia Caprio, Ilene Fennoy, Michael Freemark, Francine R. Kaufman, Robert H. Lustig, Janet H. Silverstein, et al. “Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion..” J Clin Endocrinol Metab 93, no. 12 (December 2008): 4576–99. https://doi.org/10.1210/jc.2007-2458.

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Arumugam, Ramamani, Eric Horowitz, Danhong Lu, J Jason Collier, Sarah Ronnebaum, Don Fleenor, and Michael Freemark. “The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy..” Endocrinology 149, no. 11 (November 2008): 5401–14. https://doi.org/10.1210/en.2008-0051.

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Higgins, Steven P., Michael Freemark, and Neil S. Prose. “Acanthosis nigricans: a practical approach to evaluation and management..” Dermatol Online J 14, no. 9 (September 15, 2008).

Scholars@Duke

Artz, Evelyn, Julia Warren-Ulanch, Dorothy Becker, Susan Greenspan, and Michael Freemark. “Seropositivity to celiac antigens in asymptomatic children with type 1 diabetes mellitus: association with weight, height, and bone mineralization..” Pediatr Diabetes 9, no. 4 Pt 1 (July 28, 2008): 277–84. https://doi.org/10.1111/j.1399-5448.2008.00386.x.

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Viengchareun, Say, Nathalie Servel, Bruno Fève, Michael Freemark, Marc Lombès, and Nadine Binart. “Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2..” Plos One 3, no. 2 (February 6, 2008). https://doi.org/10.1371/journal.pone.0001535.

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Haqq, Andrea M., Michael Muehlbauer, Laura P. Svetkey, Christopher B. Newgard, Jonathan Q. Purnell, Steven C. Grambow, and Michael S. Freemark. “Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones..” Clin Endocrinol (Oxf) 67, no. 6 (December 2007): 944–51. https://doi.org/10.1111/j.1365-2265.2007.02991.x.

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Freemark, M. “Metabolic Consequences of Obesity and Their Management,” October 4, 2007, 419–35. https://doi.org/10.1002/9780470987117.ch20.

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