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Michael Cohen-Wolkowiez, MD, PhD

Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 300 West Morgan Street, Box 3850, Durham, NC 27701
Phone: (919) 668-8812
Email address: michael.cohenwolkowiez@duke.edu

Pharmacokinetics and Pharmacodynamics of drugs in children with an emphasis in anti-infective products.

Education and Training

  • Pediatric Infectious Diseases Fellowship, Pediatrics, Duke University, 2006 - 2009
  • Pediatric Chief Resident, Pediatrics, University of Miami, 2005 - 2006
  • Pediatric Residency, Pediatrics, University of Miami, 2002 - 2005
  • Ph.D., University of North Carolina at Chapel Hill School of Medicine, 2012
  • M.D., Universidad Central De Venezuela (Venezuela), 2001

Selected Grants and Awards

Publications

Noveck, RJ, Guptill, JT, Cohen-Wolkowiez, M, Hauser, BM, and Suffredini, AF. "DOSE-RELATED INFLAMMATORY EFFECTS OF INTRAVENOUS ENDOTOXIN IN HUMANS: EVALUATION OF A NEW CLINICAL LOT (CCRE LOT 94332B1) OF ESCHERICHIA COLIO: 113 ENDOTOXIN (LPS)." March 2018.

Scholars@Duke

Gerhart, JG, Watt, KM, Edginton, A, Wade, KC, Jr, BDK, Smith, PB, Hornik, CP, Cohen-Wolkowiez, M, Duara, S, Ross, AS, Shattuck, K, Stewart, DL, Neu, N, and Gonzalez, D. "PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING OF FLUCONAZOLE USING PLASMA AND CEREBROSPINAL FLUID SAMPLES COLLECTED FROM PRETERM AND TERM INFANTS." March 2018.

Scholars@Duke

Dallefeld, SH, Atz, AM, Yogev, R, Sullivan, JE, Al-Uzri, A, Mendley, SR, Laughon, M, Hornik, CP, Melloni, C, Harper, B, Lewandowski, A, Mitchell, J, Wu, H, Green, TP, and Cohen-Wolkowiez, M. "A pharmacokinetic model for amiodarone in infants developed from an opportunistic sampling trial and published literature data." Journal of pharmacokinetics and pharmacodynamics (February 12, 2018).

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Le, J, Poindexter, B, Sullivan, JE, Laughon, M, Delmore, P, Blackford, M, Yogev, R, James, LP, Melloni, C, Harper, B, Mitchell, J, Benjamin, DK, Boakye-Agyeman, F, and Cohen-Wolkowiez, M. "Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates." Therapeutic drug monitoring 40, no. 1 (February 2018): 103-108.

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Autmizguine, J, Tan, S, Cohen-Wolkowiez, M, Cotten, CM, Wiederhold, N, Goldberg, RN, Adams-Chapman, I, Stoll, BJ, Smith, PB, Benjamin, DK, and NICHD Neonatal Research Network, . "Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis." The Pediatric infectious disease journal (January 24, 2018).

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Hornik, CP, Onufrak, NJ, Smith, PB, Cohen-Wolkowiez, M, Laughon, MM, Clark, RH, and Gonzalez, D. "Association between oral sildenafil dosing, predicted exposure, and systemic hypotension in hospitalised infants." Cardiology in the young 28, no. 1 (January 2018): 85-92.

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Autmizguine, J, Melloni, C, Hornik, CP, Dallefeld, S, Harper, B, Yogev, R, Sullivan, JE, Atz, AM, Al-Uzri, A, Mendley, S, Poindexter, B, Mitchell, J, Lewandowski, A, Delmore, P, Cohen-Wolkowiez, M, Gonzalez, D, and the Pediatric Trials Network Steering Committee, . "Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children." Antimicrobial agents and chemotherapy 62, no. 1 (January 2018).

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Salerno, SN, Edginton, A, Cohen-Wolkowiez, M, Hornik, CP, Watt, KM, Jamieson, BD, and Gonzalez, D. "Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid." CPT: pharmacometrics & systems pharmacology 6, no. 12 (December 2017): 814-822.

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Hwang, MF, Beechinor, RJ, Wade, KC, Benjamin, DK, Smith, PB, Hornik, CP, Capparelli, EV, Duara, S, Kennedy, KA, Cohen-Wolkowiez, M, and Gonzalez, D. "External Evaluation of Two Fluconazole Infant Population Pharmacokinetic Models." Antimicrobial agents and chemotherapy 61, no. 12 (December 2017).

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Hornik, CP, Wu, H, Edginton, AN, Watt, K, Cohen-Wolkowiez, M, and Gonzalez, D. "Development of a Pediatric Physiologically-Based Pharmacokinetic Model of Clindamycin Using Opportunistic Pharmacokinetic Data." Clinical pharmacokinetics 56, no. 11 (November 2017): 1343-1353.

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