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Michael Cohen-Wolkowiez, MD, PhD

Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 300 West Morgan Street, Box 3850, Durham, NC 27701
Phone: (919) 668-8812
Email address: michael.cohenwolkowiez@duke.edu

Pharmacokinetics and Pharmacodynamics of drugs in children with an emphasis in anti-infective products.

Education and Training

  • Pediatric Infectious Diseases Fellowship, Pediatrics, Duke University, 2006 - 2009
  • Pediatric Chief Resident, Pediatrics, University of Miami, 2005 - 2006
  • Pediatric Residency, Pediatrics, University of Miami, 2002 - 2005
  • Ph.D., University of North Carolina at Chapel Hill School of Medicine, 2012
  • M.D., Universidad Central De Venezuela (Venezuela), 2001

Selected Grants and Awards

Publications

Fisher, J. W., H. Wu, M. Cohen-Wolkowiez, K. Watt, J. Wang, G. J. Burckart, J. A. Troutman, and X. Yang. “Predicting the pharmacokinetics of piperacillin and tazobactam in preterm and term neonates using physiologically based pharmacokinetic modeling.” Computational Toxicology 12 (November 1, 2019). https://doi.org/10.1016/j.comtox.2019.100104.

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Balevic, Stephen J., P Brian Smith, Daniela Testoni, Huali Wu, Kim L. R. Brouwer, Kanecia O. Zimmerman, Nazario D. Rivera-Chaparro, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Cefazolin pharmacokinetics in premature infants..” J Perinatol 39, no. 9 (September 2019): 1213–18. https://doi.org/10.1038/s41372-019-0368-z.

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Hornik, Christoph P., Ram Yogev, Peter M. Mourani, Kevin M. Watt, Janice E. Sullivan, Andrew M. Atz, David Speicher, et al. “Population Pharmacokinetics of Milrinone in Infants, Children, and Adolescents..” J Clin Pharmacol, July 17, 2019. https://doi.org/10.1002/jcph.1499.

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Beechinor, Ryan J., Michael Cohen-Wolkowiez, Theresa Jasion, Christoph P. Hornik, Jason E. Lang, Robert Hernandez, and Daniel Gonzalez. “A Dried Blood Spot Analysis for Solithromycin in Adolescents, Children, and Infants: A Short Communication..” Ther Drug Monit, July 15, 2019. https://doi.org/10.1097/FTD.0000000000000670.

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Thompson, Elizabeth J., Huali Wu, Anil Maharaj, Andrea N. Edginton, Stephen J. Balevic, Marjan Cobbaert, Anthony P. Cunningham, Christoph P. Hornik, and Michael Cohen-Wolkowiez. “Physiologically Based Pharmacokinetic Modeling for Trimethoprim and Sulfamethoxazole in Children..” Clin Pharmacokinet 58, no. 7 (July 2019): 887–98. https://doi.org/10.1007/s40262-018-00733-1.

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Gerhart, Jacqueline G., Kevin M. Watt, Andrea Edginton, Kelly C. Wade, Sara N. Salerno, Daniel K. Benjamin, P Brian Smith, et al. “Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants..” In Cpt Pharmacometrics Syst Pharmacol, 8:500–510, 2019. https://doi.org/10.1002/psp4.12414.

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Maharaj, Anil R., Huali Wu, Christoph P. Hornik, and Michael Cohen-Wolkowiez. “Pitfalls of using numerical predictive checks for population physiologically-based pharmacokinetic model evaluation..” J Pharmacokinet Pharmacodyn 46, no. 3 (June 2019): 263–72. https://doi.org/10.1007/s10928-019-09636-5.

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Smith, P Brian, C Michael Cotten, Mark L. Hudak, Janice E. Sullivan, Brenda B. Poindexter, Michael Cohen-Wolkowiez, Felix Boakye-Agyeman, et al. “Rifampin Pharmacokinetics and Safety in Preterm and Term Infants..” Antimicrob Agents Chemother 63, no. 6 (June 2019). https://doi.org/10.1128/AAC.00284-19.

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Watt, Kevin M., Christoph P. Hornik, Stephen J. Balevic, Gratias Mundakel, C Michael Cotten, Barrie Harper, Daniel K. Benjamin, et al. “Pharmacokinetics of ticarcillin-clavulanate in premature infants..” Br J Clin Pharmacol 85, no. 5 (May 2019): 1021–27. https://doi.org/10.1111/bcp.13882.

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Balevic, Stephen J., Thomas P. Green, Megan E. B. Clowse, Amanda M. Eudy, Laura E. Schanberg, and Michael Cohen-Wolkowiez. “Pharmacokinetics of Hydroxychloroquine in Pregnancies with Rheumatic Diseases..” Clin Pharmacokinet 58, no. 4 (April 2019): 525–33. https://doi.org/10.1007/s40262-018-0712-z.

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