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Michael Cohen-Wolkowiez, MD, PhD

Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 300 West Morgan Street, Box 3850, Durham, NC 27701
Phone: (919) 668-8812
Email address: michael.cohenwolkowiez@duke.edu

Pharmacokinetics and Pharmacodynamics of drugs in children with an emphasis in anti-infective products.

Education and Training

  • Pediatric Infectious Diseases Fellowship, Pediatrics, Duke University, 2006 - 2009
  • Pediatric Chief Resident, Pediatrics, University of Miami, 2005 - 2006
  • Pediatric Residency, Pediatrics, University of Miami, 2002 - 2005
  • Ph.D., University of North Carolina at Chapel Hill School of Medicine, 2012
  • M.D., Universidad Central De Venezuela (Venezuela), 2001

Selected Grants and Awards

Publications

Rivera-Chaparro, ND, Ericson, J, Wu, H, Smith, PB, Clark, RH, Benjamin, DK, Cohen-Wolkowiez, M, and Greenberg, RG. "Safety, Effectiveness and Exposure-response of Micafungin in Infants: Application of an Established Pharmacokinetics Model to Electronic Health Records." The Pediatric Infectious Disease Journal 38, no. 2 (February 2019): e26-e28.

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Balevic, SJ, Cohen-Wolkowiez, M, Eudy, AM, Green, TP, Schanberg, LE, and Clowse, MEB. "Hydroxychloroquine Levels throughout Pregnancies Complicated by Rheumatic Disease: Implications for Maternal and Neonatal Outcomes." The Journal of Rheumatology 46, no. 1 (January 2019): 57-63.

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Cohen-Wolkowiez, M, and Benjamin, DK. "Development of Therapeutics for Children-A Tricky Balancing Act." Jama Pediatrics (November 19, 2018).

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Ku, LC, Hornik, CP, Beechinor, RJ, Chamberlain, JM, Guptill, JT, Harper, B, Capparelli, EV, Martz, K, Anand, R, Cohen-Wolkowiez, M, Gonzalez, D, and Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee, . "Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus." Cpt: Pharmacometrics & Systems Pharmacology 7, no. 11 (November 2018): 718-727.

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Shakhnovich, V, Brian Smith, P, Guptill, JT, James, LP, Collier, DN, Wu, H, Livingston, CE, Zhao, J, Kearns, GL, Cohen-Wolkowiez, M, and Best Pharmaceuticals for Children Act–Pediatric Trials Network, . "A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents." Paediatric Drugs 20, no. 5 (October 2018): 483-495.

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Balevic, SJ, and Cohen-Wolkowiez, M. "Innovative Study Designs Optimizing Clinical Pharmacology Research in Infants and Children." Journal of Clinical Pharmacology 58 Suppl 10 (October 2018): S58-S72.

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Watt, KM, Cohen-Wolkowiez, M, Barrett, JS, Sevestre, M, Zhao, P, Brouwer, KLR, and Edginton, AN. "Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO." Cpt: Pharmacometrics & Systems Pharmacology 7, no. 10 (October 2018): 629-637.

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Balevic, SJ, Green, TP, Clowse, MEB, Eudy, AM, Schanberg, LE, and Cohen-Wolkowiez, M. "Pharmacokinetics of Hydroxychloroquine in Pregnancies with Rheumatic Diseases." Clinical Pharmacokinetics (September 25, 2018).

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Autmizguine, J, Tan, S, Cohen-Wolkowiez, M, Cotten, CM, Wiederhold, N, Goldberg, RN, Adams-Chapman, I, Stoll, BJ, Smith, PB, Benjamin, DK, and NICHD Neonatal Research Network, . "Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis." The Pediatric Infectious Disease Journal 37, no. 9 (September 2018): 923-929.

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Ge, S, Beechinor, RJ, Hornik, CP, Standing, JF, Zimmerman, K, Cohen-Wolkowiez, M, Laughon, MM, Clark, R, and Gonzalez, D. "External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database." Antimicrobial Agents and Chemotherapy 62, no. 9 (September 2018).

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