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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and Assistant Professor of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza, syphilis, autoimmunity, and is interested in applying the technique to other disease processes.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Pollara, Justin, Mattia Bonsignori, M Anthony Moody, Pinghuang Liu, S Munir Alam, Kwan-Ki Hwang, Thaddeus C. Gurley, et al. “HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities..” J Virol 88, no. 14 (July 2014): 7715–26. https://doi.org/10.1128/JVI.00156-14.

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Garcia, Ambrosia, Sarah Keinonen, Ana M. Sanchez, Guido Ferrari, Thomas N. Denny, and M Anthony Moody. “Leukopak PBMC sample processing for preparing quality control material to support proficiency testing programs..” J Immunol Methods 409 (July 2014): 99–106. https://doi.org/10.1016/j.jim.2014.05.019.

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Haynes, Barton F., M Anthony Moody, Munir Alam, Mattia Bonsignori, Laurent Verkoczy, Guido Ferrari, Feng Gao, Georgia D. Tomaras, Hua-Xin Liao, and Garnett Kelsoe. “Progress in HIV-1 vaccine development..” J Allergy Clin Immunol 134, no. 1 (July 2014): 3–10. https://doi.org/10.1016/j.jaci.2014.04.025.

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Madani, Navid, Amy M. Princiotto, Arne Schön, Judith LaLonde, Yu Feng, Ernesto Freire, Jongwoo Park, et al. “CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies..” J Virol 88, no. 12 (June 2014): 6542–55. https://doi.org/10.1128/JVI.00540-14.

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Liu, Pinghuang, Latonya D. Williams, Xiaoying Shen, Mattia Bonsignori, Nathan A. Vandergrift, R Glenn Overman, M Anthony Moody, et al. “Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity..” J Virol 88, no. 9 (May 2014): 5165–70. https://doi.org/10.1128/JVI.03765-13.

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Moody, M Anthony. “Modulation of HIV-1 immunity by adjuvants..” Curr Opin Hiv Aids 9, no. 3 (May 2014): 242–49. https://doi.org/10.1097/COH.0000000000000052.

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Bonsignori, Mattia, Kevin Wiehe, Sebastian K. Grimm, Rebecca Lynch, Guang Yang, Daniel M. Kozink, Florence Perrin, et al. “An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1..” J Clin Invest 124, no. 4 (April 2014): 1835–43. https://doi.org/10.1172/JCI73441.

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Holl, T Matt, Guang Yang, Masayuki Kuraoka, Laurent Verkoczy, S Munir Alam, M Anthony Moody, Barton F. Haynes, and Garnett Kelsoe. “Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes..” J Immunol 192, no. 7 (April 1, 2014): 3269–79. https://doi.org/10.4049/jimmunol.1302829.

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Moody, M Anthony, Sampa Santra, Nathan A. Vandergrift, Laura L. Sutherland, Thaddeus C. Gurley, Mark S. Drinker, Ashley A. Allen, et al. “Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques..” J Virol 88, no. 6 (March 2014): 3329–39. https://doi.org/10.1128/JVI.03309-13.

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Seaton, Kelly E., Lamar Ballweber, Audrey Lan, Michele Donathan, Sean Hughes, Lucia Vojtech, M Anthony Moody, et al. “HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 specificities..” Plos One 9, no. 7 (2014). https://doi.org/10.1371/journal.pone.0101863.

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