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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and Assistant Professor of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza, syphilis, autoimmunity, and is interested in applying the technique to other disease processes.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Xu, Huafeng, Aaron G. Schmidt, Timothy O’Donnell, Matthew D. Therkelsen, Thomas B. Kepler, M Anthony Moody, Barton F. Haynes, Hua-Xin Liao, Stephen C. Harrison, and David E. Shaw. “Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage..” Proteins 83, no. 4 (April 2015): 771–80. https://doi.org/10.1002/prot.24745.

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Sacha, C. R., N. Vandergrift, T. L. Jeffries, E. McGuire, G. G. Fouda, B. Liebl, D. J. Marshall, et al. “Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women..” Mucosal Immunol 8, no. 2 (March 2015): 316–26. https://doi.org/10.1038/mi.2014.69.

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Fouda, Genevieve G., Coleen K. Cunningham, Elizabeth J. McFarland, William Borkowsky, Petronella Muresan, Justin Pollara, Lin Ye Song, et al. “Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses..” J Infect Dis 211, no. 4 (February 15, 2015): 508–17. https://doi.org/10.1093/infdis/jiu444.

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Wiehe, Kevin, David Easterhoff, Kan Luo, Nathan I. Nicely, Todd Bradley, Frederick H. Jaeger, S Moses Dennison, et al. “Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved..” Immunity 41, no. 6 (December 18, 2014): 909–18. https://doi.org/10.1016/j.immuni.2014.11.014.

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Moody, M. A., D. Easterhoff, T. C. Gurley, J. F. Whitesides, D. J. Marshall, A. Foulger, K. E. Lloyd, et al. “Induction of Antibodies with Long Variable Heavy Third Complementarity Determining Regions by Repetitive Boosting with AIDSVAX® B/E in RV144 Vaccinees..” In Aids Res Hum Retroviruses, Vol. 30 Suppl 1, 2014. https://doi.org/10.1089/aid.2014.5057a.abstract.

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Liao, L. H., A. M. Trama, W. B. Williams, M. A. Moody, N. Vandergrift, G. D. Tomaras, D. J. Marshall, et al. “Role of Intestinal Microbiota in Shaping the B Cell Repertoire in HIV Infection and Env Vaccination..” In Aids Res Hum Retroviruses, Vol. 30 Suppl 1, 2014. https://doi.org/10.1089/aid.2014.5023a.abstract.

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Kepler, Thomas B., Hua-Xin Liao, S Munir Alam, Rekha Bhaskarabhatla, Ruijun Zhang, Chandri Yandava, Shelley Stewart, et al. “Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies..” Cell Host Microbe 16, no. 3 (September 10, 2014): 304–13. https://doi.org/10.1016/j.chom.2014.08.006.

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Trama, Ashley M., M Anthony Moody, S Munir Alam, Frederick H. Jaeger, Bradley Lockwood, Robert Parks, Krissey E. Lloyd, et al. “HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria..” Cell Host Microbe 16, no. 2 (August 13, 2014): 215–26. https://doi.org/10.1016/j.chom.2014.07.003.

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Gao, Feng, Mattia Bonsignori, Hua-Xin Liao, Amit Kumar, Shi-Mao Xia, Xiaozhi Lu, Fangping Cai, et al. “Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies..” Cell 158, no. 3 (July 31, 2014): 481–91. https://doi.org/10.1016/j.cell.2014.06.022.

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Jackson, Katherine J. L., Yi Liu, Krishna M. Roskin, Jacob Glanville, Ramona A. Hoh, Katie Seo, Eleanor L. Marshall, et al. “Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements..” Cell Host Microbe 16, no. 1 (July 9, 2014): 105–14. https://doi.org/10.1016/j.chom.2014.05.013.

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