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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and the Department of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI.  Dr. Moody is also the Director of the CHAVI DHVI Repository that provides support for the collaborative work occurring at DHVI and with its many collaborators around the world by providing processing, shipping, and inventory support for a wide array of projects. Additionally, Dr. Moody serves as one of the Principal Investigators of the new Duke Collaborative Influenza Vaccine Innovation Centers (CIVICs) where he will conduct basic immunology and virology research to identify potential influenza vaccine candidates.

In addition, the Moody lab has active projects looking at the response to HIV-1, syphilis, and autoimmunity.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Chuang, Gwo-Yu, Baoshan Zhang, Krisha McKee, Sijy O’Dell, Young Do Kwon, Tongqing Zhou, Julie Blinn, et al. “Eliminating antibody polyreactivity through addition of N-linked glycosylation.” Protein Sci 24, no. 6 (June 2015): 1019–30. https://doi.org/10.1002/pro.2682.

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Schmidt, Aaron G., Matthew D. Therkelsen, Shaun Stewart, Thomas B. Kepler, Hua-Xin Liao, M Anthony Moody, Barton F. Haynes, and Stephen C. Harrison. “Viral receptor-binding site antibodies with diverse germline origins.” Cell 161, no. 5 (May 21, 2015): 1026–34. https://doi.org/10.1016/j.cell.2015.04.028.

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Fouda, Genevieve G., M Anthony Moody, and Sallie R. Permar. “Antibodies for prevention of mother-to-child transmission of HIV-1.” Curr Opin Hiv Aids 10, no. 3 (May 2015): 177–82. https://doi.org/10.1097/COH.0000000000000150.

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Xu, H., A. G. Schmidt, T. O’Donnell, M. D. Therkelsen, T. B. Kepler, M. A. Moody, B. F. Haynes, H. X. Liao, S. C. Harrison, and D. E. Shaw. “Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.” Proteins: Structure, Function and Bioinformatics 83, no. 4 (April 1, 2015): 771–80. https://doi.org/10.1002/prot.24745.

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Xu, Huafeng, Aaron G. Schmidt, Timothy O’Donnell, Matthew D. Therkelsen, Thomas B. Kepler, M Anthony Moody, Barton F. Haynes, Hua-Xin Liao, Stephen C. Harrison, and David E. Shaw. “Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.” Proteins 83, no. 4 (April 2015): 771–80. https://doi.org/10.1002/prot.24745.

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Sacha, C. R., N. Vandergrift, T. L. Jeffries, E. McGuire, G. G. Fouda, B. Liebl, D. J. Marshall, et al. “Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women.” Mucosal Immunol 8, no. 2 (March 2015): 316–26. https://doi.org/10.1038/mi.2014.69.

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Fouda, Genevieve G., Coleen K. Cunningham, Elizabeth J. McFarland, William Borkowsky, Petronella Muresan, Justin Pollara, Lin Ye Song, et al. “Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses.” J Infect Dis 211, no. 4 (February 15, 2015): 508–17. https://doi.org/10.1093/infdis/jiu444.

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Wiehe, Kevin, David Easterhoff, Kan Luo, Nathan I. Nicely, Todd Bradley, Frederick H. Jaeger, S Moses Dennison, et al. “Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.” Immunity 41, no. 6 (December 18, 2014): 909–18. https://doi.org/10.1016/j.immuni.2014.11.014.

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Moody, M. A., D. Easterhoff, T. C. Gurley, J. F. Whitesides, D. J. Marshall, A. Foulger, K. E. Lloyd, et al. “Induction of Antibodies with Long Variable Heavy Third Complementarity Determining Regions by Repetitive Boosting with AIDSVAX® B/E in RV144 Vaccinees.” In Aids Res Hum Retroviruses, 30 Suppl 1:A36, 2014. https://doi.org/10.1089/aid.2014.5057a.abstract.

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Liao, L. H., A. M. Trama, W. B. Williams, M. A. Moody, N. Vandergrift, G. D. Tomaras, D. J. Marshall, et al. “Role of Intestinal Microbiota in Shaping the B Cell Repertoire in HIV Infection and Env Vaccination.” In Aids Res Hum Retroviruses, 30 Suppl 1:A19, 2014. https://doi.org/10.1089/aid.2014.5023a.abstract.

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