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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and the Department of Immunology at Duke University Medical Center. Research in the Moody lab is focused on understanding the B cell responses during infection, vaccination, and disease. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at the Duke Human Vaccine Institute (DHVI). The Moody lab is currently funded to study influenza, syphilis, HIV-1, and emerging infectious diseases.

Dr. Moody is the director of the Duke CIVICs Vaccine Center (DCVC) at (DHVI) and co-director of the Centers for Research of Emerging Infectious Disease Coordinating Center (CREID-CC). Dr. Moody is co-PI of a U19 program to develop a syphilis vaccine; this program is led by Dr. Justin Radolf at the University of Connecticut. Dr. Moody is also the director of the DHVI Accessioning Unit, a biorepository that provides support for work occurring at DHVI and with its many collaborators around the world by providing processing, shipping, and inventory support for a wide array of projects.

Dr. Moody and his team are involved in many networks studying vaccine response including the Collaborative Influenza Vaccine Innovation Centers (CIVICs), HIV Vaccine Trials Network (HVTN) and the COVID-19 Prevention Network (CoVPN).

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Seña, Arlene C., Xiao-Hui Zhang, Trudy Li, He-Ping Zheng, Bin Yang, Li-Gang Yang, Juan C. Salazar, et al. “A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy.” Bmc Infect Dis 15 (October 28, 2015): 479. https://doi.org/10.1186/s12879-015-1209-0.

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Hraber, Peter, Bette Korber, Kshitij Wagh, Elena E. Giorgi, Tanmoy Bhattacharya, S. Gnanakaran, Alan S. Lapedes, et al. “Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants.” Viruses 7, no. 10 (October 21, 2015): 5443–75. https://doi.org/10.3390/v7102881.

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Moody, M Anthony, Feng Gao, Thaddeus C. Gurley, Joshua D. Amos, Amit Kumar, Bhavna Hora, Dawn J. Marshall, et al. “Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses.” Cell Host Microbe 18, no. 3 (September 9, 2015): 354–62. https://doi.org/10.1016/j.chom.2015.08.006.

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Amos, Joshua D., Jonathon E. Himes, Lawrence Armand, Thaddeus C. Gurley, David R. Martinez, Lisa Colvin, Krista Beck, et al. “Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys.” J Virol 89, no. 18 (September 2015): 9485–98. https://doi.org/10.1128/JVI.01564-15.

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Williams, Wilton B., Hua-Xin Liao, M Anthony Moody, Thomas B. Kepler, S Munir Alam, Feng Gao, Kevin Wiehe, et al. “HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.” Science 349, no. 6249 (August 14, 2015): aab1253. https://doi.org/10.1126/science.aab1253.

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Santra, Sampa, Georgia D. Tomaras, Ranjit Warrier, Nathan I. Nicely, Hua-Xin Liao, Justin Pollara, Pinghuang Liu, et al. “Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.” Plos Pathog 11, no. 8 (August 2015): e1005042. https://doi.org/10.1371/journal.ppat.1005042.

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Permar, Sallie R., Youyi Fong, Nathan Vandergrift, Genevieve G. Fouda, Peter Gilbert, Robert Parks, Frederick H. Jaeger, et al. “Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission.” J Clin Invest 125, no. 7 (July 1, 2015): 2702–6. https://doi.org/10.1172/JCI81593.

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Chuang, Gwo-Yu, Baoshan Zhang, Krisha McKee, Sijy O’Dell, Young Do Kwon, Tongqing Zhou, Julie Blinn, et al. “Eliminating antibody polyreactivity through addition of N-linked glycosylation.” Protein Sci 24, no. 6 (June 2015): 1019–30. https://doi.org/10.1002/pro.2682.

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Schmidt, Aaron G., Matthew D. Therkelsen, Shaun Stewart, Thomas B. Kepler, Hua-Xin Liao, M Anthony Moody, Barton F. Haynes, and Stephen C. Harrison. “Viral receptor-binding site antibodies with diverse germline origins.” Cell 161, no. 5 (May 21, 2015): 1026–34. https://doi.org/10.1016/j.cell.2015.04.028.

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Fouda, Genevieve G., M Anthony Moody, and Sallie R. Permar. “Antibodies for prevention of mother-to-child transmission of HIV-1.” Curr Opin Hiv Aids 10, no. 3 (May 2015): 177–82. https://doi.org/10.1097/COH.0000000000000150.

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