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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and Assistant Professor of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza, syphilis, autoimmunity, and is interested in applying the technique to other disease processes.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Alam, S Munir, Baptiste Aussedat, Yusuf Vohra, R Ryan Meyerhoff, Evan M. Cale, William E. Walkowicz, Nathan A. Radakovich, et al. “Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide..” Sci Transl Med 9, no. 381 (March 15, 2017). https://doi.org/10.1126/scitranslmed.aai7521.

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Bonsignori, Mattia, Edward F. Kreider, Daniela Fera, R Ryan Meyerhoff, Todd Bradley, Kevin Wiehe, S Munir Alam, et al. “Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies..” Sci Transl Med 9, no. 381 (March 15, 2017). https://doi.org/10.1126/scitranslmed.aai7514.

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Saunders, Kevin O., Nathan I. Nicely, Kevin Wiehe, Mattia Bonsignori, R Ryan Meyerhoff, Robert Parks, William E. Walkowicz, et al. “Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates..” Cell Rep 18, no. 9 (February 28, 2017): 2175–88. https://doi.org/10.1016/j.celrep.2017.02.003.

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Easterhoff, David, M Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O. Saunders, et al. “Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial..” Plos Pathog 13, no. 2 (February 2017). https://doi.org/10.1371/journal.ppat.1006182.

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Wiehe, Kevin, Nathan I. Nicely, Bradley Lockwood, Masayuki Kuraoka, Kara Anasti, Sabrina Arora, Cindy M. Bowman, et al. “Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice..” J Immunol 198, no. 3 (February 1, 2017): 1047–55. https://doi.org/10.4049/jimmunol.1601640.

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Williams, LaTonya D., Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, et al. “Potent and broad HIV-neutralizing antibodies in memory B cells and plasma..” Sci Immunol 2, no. 7 (January 27, 2017). https://doi.org/10.1126/sciimmunol.aal2200.

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Buchbinder, Susan P., Nicole A. Grunenberg, Brittany J. Sanchez, Kelly E. Seaton, Guido Ferrari, M Anthony Moody, Nicole Frahm, et al. “Immunogenicity of a novel Clade B HIV-1 vaccine combination: Results of phase 1 randomized placebo controlled trial of an HIV-1 GM-CSF-expressing DNA prime with a modified vaccinia Ankara vaccine boost in healthy HIV-1 uninfected adults..” Plos One 12, no. 7 (2017). https://doi.org/10.1371/journal.pone.0179597.

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Borrow, Persephone, and M Anthony Moody. “Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies..” Immunol Rev 275, no. 1 (January 2017): 62–78. https://doi.org/10.1111/imr.12504.

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Bradley, Todd, Guang Yang, Olga Ilkayeva, T Matt Holl, Ruijun Zhang, Jinsong Zhang, Sampa Santra, et al. “HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism..” J Immunol 197, no. 12 (December 15, 2016): 4663–73. https://doi.org/10.4049/jimmunol.1601484.

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Luo, Kan, Hua-Xin Liao, Ruijun Zhang, David Easterhoff, Kevin Wiehe, Thaddeus C. Gurley, Lawrence C. Armand, et al. “Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques..” Jci Insight 1, no. 20 (December 8, 2016). https://doi.org/10.1172/jci.insight.88522.

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