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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and Assistant Professor of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza, syphilis, autoimmunity, and is interested in applying the technique to other disease processes.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Williams, Wilton B., Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M Anthony Moody, et al. “Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations..” Nat Commun 8, no. 1 (November 23, 2017). https://doi.org/10.1038/s41467-017-01336-3.

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Mohr, Emma L., Dawn M. Dudley, Matthew T. Aliota, Andrea Weiler, Gabrielle Lehrer-Brey, Kim L. Weisgrau, Mariel S. Mohns, et al. “DEVELOPMENT OF A NONHUMAN PRIMATE MODEL OF ZIKA VIRUS INFECTION IN PREGNANT AND NON-PREGNANT RHESUS MACAQUES.” In American Journal of Tropical Medicine and Hygiene, 95:570–570. AMER SOC TROP MED & HYGIENE, 2017.

Scholars@Duke

Han, Qifeng, Wilton B. Williams, Kevin O. Saunders, Kelly E. Seaton, Kevin J. Wiehe, Nathan Vandergrift, Tarra A. Von Holle, et al. “HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques..” J Virol 91, no. 21 (November 1, 2017). https://doi.org/10.1128/JVI.00923-17.

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Phillips, Bonnie, Genevieve G. Fouda, Josh Eudailey, Justin Pollara, Alan D. Curtis, Erika Kunz, Maria Dennis, et al. “Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques..” Clin Vaccine Immunol 24, no. 10 (October 2017). https://doi.org/10.1128/CVI.00231-17.

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Wang, Kening, Georgia D. Tomaras, Sinthujan Jegaskanda, M Anthony Moody, Hua-Xin Liao, Kyle N. Goodman, Phillip W. Berman, et al. “Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1..” J Virol 91, no. 19 (October 1, 2017). https://doi.org/10.1128/JVI.00411-17.

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Bradley, Todd, Justin Pollara, Sampa Santra, Nathan Vandergrift, Srivamshi Pittala, Chris Bailey-Kellogg, Xiaoying Shen, et al. “Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge..” Nat Commun 8 (June 8, 2017). https://doi.org/10.1038/ncomms15711.

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Saleh, Ezzeldin, Geeta K. Swamy, M Anthony Moody, and Emmanuel B. Walter. “Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study..” Clin Pediatr (Phila) 56, no. 5 (May 2017): 435–42. https://doi.org/10.1177/0009922816675116.

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Fan, Qihua, Cody S. Nelson, Kristy M. Bialas, Flavia Chiuppesi, Joshua Amos, Thaddeus C. Gurley, Dawn Jones Marshall, et al. “Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission..” Clin Vaccine Immunol 24, no. 5 (May 2017). https://doi.org/10.1128/CVI.00510-16.

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Knox, James J., Marcus Buggert, Lela Kardava, Kelly E. Seaton, Michael A. Eller, David H. Canaday, Merlin L. Robb, et al. “T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response..” Jci Insight 2, no. 8 (April 20, 2017). https://doi.org/10.1172/jci.insight.92943.

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Prévost, Jérémie, Daria Zoubchenok, Jonathan Richard, Maxime Veillette, Beatriz Pacheco, Mathieu Coutu, Nathalie Brassard, et al. “Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses..” J Virol 91, no. 7 (April 1, 2017). https://doi.org/10.1128/JVI.02452-16.

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