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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and the Department of Immunology at Duke University Medical Center. Research in the Moody lab is focused on understanding the B cell responses during infection, vaccination, and disease. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at the Duke Human Vaccine Institute (DHVI). The Moody lab is currently funded to study influenza, syphilis, HIV-1, and emerging infectious diseases.

Dr. Moody is the director of the Duke CIVICs Vaccine Center (DCVC) at (DHVI) and co-director of the Centers for Research of Emerging Infectious Disease Coordinating Center (CREID-CC). Dr. Moody is co-PI of a U19 program to develop a syphilis vaccine; this program is led by Dr. Justin Radolf at the University of Connecticut. Dr. Moody is also the director of the DHVI Accessioning Unit, a biorepository that provides support for work occurring at DHVI and with its many collaborators around the world by providing processing, shipping, and inventory support for a wide array of projects.

Dr. Moody and his team are involved in many networks studying vaccine response including the Collaborative Influenza Vaccine Innovation Centers (CIVICs), HIV Vaccine Trials Network (HVTN) and the COVID-19 Prevention Network (CoVPN).

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Ferdman, Jack, Giuseppe Palladino, Hua-Xin Liao, M Anthony Moody, Thomas B. Kepler, Giuseppe Del Giudice, Philip R. Dormitzer, Stephen C. Harrison, Ethan C. Settembre, and Pirada Suphaphiphat. “Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine.” Vaccine 36, no. 35 (August 23, 2018): 5325–32. https://doi.org/10.1016/j.vaccine.2018.06.054.

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Chaires, Hector, Goran Bajic, Michael Moody, and Stephen Harrison. “Structure of influenza hemagglutinin antibody from Rhesus Macaque with disulfide bond in its CDRH3.” In Abstracts of Papers of the American Chemical Society, Vol. 256. AMER CHEMICAL SOC, 2018.

Scholars@Duke

Moody, M Anthony. “Strength through Organization: Classifying Antibody Activity against EBOV.” Cell Host Microbe 24, no. 2 (August 8, 2018): 185–86. https://doi.org/10.1016/j.chom.2018.07.015.

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Madani, Navid, Amy M. Princiotto, Linh Mach, Shilei Ding, Jérémie Prevost, Jonathan Richard, Bhavna Hora, et al. “A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge.” Nat Commun 9, no. 1 (June 18, 2018): 2363. https://doi.org/10.1038/s41467-018-04758-9.

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Pardi, Norbert, Michael J. Hogan, Martin S. Naradikian, Kaela Parkhouse, Derek W. Cain, Letitia Jones, M Anthony Moody, et al. “Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.” J Exp Med 215, no. 6 (June 4, 2018): 1571–88. https://doi.org/10.1084/jem.20171450.

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DeKosky, Brandon J., Bo Wang, Morgan Timm, Jiwon Lee, Erica Normandin, John Misasi, Rui Kong, et al. “Functional Interrogation and Mining of Natively-Paired Human V-H:V-L Antibody Repertoires.” In Journal of Immunology, Vol. 200. AMER ASSOC IMMUNOLOGISTS, 2018.

Scholars@Duke

Wills, Saintedym, Kwan-Ki Hwang, Pinghuang Liu, S Moses Dennison, Matthew Zirui Tay, Xiaoying Shen, Justin Pollara, et al. “HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis.” J Virol 92, no. 7 (April 1, 2018). https://doi.org/10.1128/JVI.01552-17.

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Wang, Bo, Brandon J. DeKosky, Morgan R. Timm, Jiwon Lee, Erica Normandin, John Misasi, Rui Kong, et al. “Functional interrogation and mining of natively paired human VH:VL antibody repertoires.” Nat Biotechnol 36, no. 2 (February 2018): 152–55. https://doi.org/10.1038/nbt.4052.

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Raymond, Donald D., Goran Bajic, Jack Ferdman, Pirada Suphaphiphat, Ethan C. Settembre, M Anthony Moody, Aaron G. Schmidt, and Stephen C. Harrison. “Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody.” Proc Natl Acad Sci U S A 115, no. 1 (January 2, 2018): 168–73. https://doi.org/10.1073/pnas.1715471115.

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Blasi, Maria, Donatella Negri, Celia LaBranche, S Munir Alam, Erich J. Baker, Elizabeth C. Brunner, Morgan A. Gladden, et al. “IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.” Commun Biol 1 (2018): 134. https://doi.org/10.1038/s42003-018-0131-6.

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