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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and the Department of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI.  Dr. Moody is also the Director of the CHAVI DHVI Repository that provides support for the collaborative work occurring at DHVI and with its many collaborators around the world by providing processing, shipping, and inventory support for a wide array of projects. Additionally, Dr. Moody serves as one of the Principal Investigators of the new Duke Collaborative Influenza Vaccine Innovation Centers (CIVICs) where he will conduct basic immunology and virology research to identify potential influenza vaccine candidates.

In addition, the Moody lab has active projects looking at the response to HIV-1, syphilis, and autoimmunity.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Wang, Bo, Brandon J. DeKosky, Morgan R. Timm, Jiwon Lee, Erica Normandin, John Misasi, Rui Kong, et al. “Functional interrogation and mining of natively paired human VH:VL antibody repertoires.” Nat Biotechnol 36, no. 2 (February 2018): 152–55. https://doi.org/10.1038/nbt.4052.

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Raymond, Donald D., Goran Bajic, Jack Ferdman, Pirada Suphaphiphat, Ethan C. Settembre, M Anthony Moody, Aaron G. Schmidt, and Stephen C. Harrison. “Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody.” Proc Natl Acad Sci U S A 115, no. 1 (January 2, 2018): 168–73. https://doi.org/10.1073/pnas.1715471115.

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Blasi, Maria, Donatella Negri, Celia LaBranche, S Munir Alam, Erich J. Baker, Elizabeth C. Brunner, Morgan A. Gladden, et al. “IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.” Commun Biol 1 (2018): 134. https://doi.org/10.1038/s42003-018-0131-6.

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Saunders, Kevin O., Laurent K. Verkoczy, Chuancang Jiang, Jinsong Zhang, Robert Parks, Haiyan Chen, Max Housman, et al. “Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models.” Cell Rep 21, no. 13 (December 26, 2017): 3681–90. https://doi.org/10.1016/j.celrep.2017.12.028.

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Williams, Wilton B., Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M Anthony Moody, et al. “Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.” Nat Commun 8, no. 1 (November 23, 2017): 1732. https://doi.org/10.1038/s41467-017-01336-3.

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Mohr, Emma L., Dawn M. Dudley, Matthew T. Aliota, Andrea Weiler, Gabrielle Lehrer-Brey, Kim L. Weisgrau, Mariel S. Mohns, et al. “DEVELOPMENT OF A NONHUMAN PRIMATE MODEL OF ZIKA VIRUS INFECTION IN PREGNANT AND NON-PREGNANT RHESUS MACAQUES.” In American Journal of Tropical Medicine and Hygiene, 95:570–570. AMER SOC TROP MED & HYGIENE, 2017.

Scholars@Duke

Han, Qifeng, Wilton B. Williams, Kevin O. Saunders, Kelly E. Seaton, Kevin J. Wiehe, Nathan Vandergrift, Tarra A. Von Holle, et al. “HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques.” J Virol 91, no. 21 (November 1, 2017). https://doi.org/10.1128/JVI.00923-17.

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Phillips, Bonnie, Genevieve G. Fouda, Josh Eudailey, Justin Pollara, Alan D. Curtis, Erika Kunz, Maria Dennis, et al. “Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques.” Clin Vaccine Immunol 24, no. 10 (October 2017). https://doi.org/10.1128/CVI.00231-17.

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Wang, Kening, Georgia D. Tomaras, Sinthujan Jegaskanda, M Anthony Moody, Hua-Xin Liao, Kyle N. Goodman, Phillip W. Berman, et al. “Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1.” J Virol 91, no. 19 (October 1, 2017). https://doi.org/10.1128/JVI.00411-17.

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Bradley, Todd, Justin Pollara, Sampa Santra, Nathan Vandergrift, Srivamshi Pittala, Chris Bailey-Kellogg, Xiaoying Shen, et al. “Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge.” Nat Commun 8 (June 8, 2017): 15711. https://doi.org/10.1038/ncomms15711.

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