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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and the Department of Immunology at Duke University Medical Center. Research in the Moody lab is focused on understanding the B cell responses during infection, vaccination, and disease. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at the Duke Human Vaccine Institute (DHVI). The Moody lab is currently funded to study influenza, syphilis, HIV-1, and emerging infectious diseases.

Dr. Moody is the director of the Duke CIVICs Vaccine Center (DCVC) at (DHVI) and co-director of the Centers for Research of Emerging Infectious Disease Coordinating Center (CREID-CC). Dr. Moody is co-PI of a U19 program to develop a syphilis vaccine; this program is led by Dr. Justin Radolf at the University of Connecticut. Dr. Moody is also the director of the DHVI Accessioning Unit, a biorepository that provides support for work occurring at DHVI and with its many collaborators around the world by providing processing, shipping, and inventory support for a wide array of projects.

Dr. Moody and his team are involved in many networks studying vaccine response including the Collaborative Influenza Vaccine Innovation Centers (CIVICs), HIV Vaccine Trials Network (HVTN) and the COVID-19 Prevention Network (CoVPN).

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Jiang, Chunlai, Nicholas F. Parrish, Craig B. Wilen, Hui Li, Yue Chen, Jeffrey W. Pavlicek, Anna Berg, et al. “Primary infection by a human immunodeficiency virus with atypical coreceptor tropism.” J Virol 85, no. 20 (October 2011): 10669–81. https://doi.org/10.1128/JVI.05249-11.

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Louder, R. K., J. McLellan, M. Pancera, S. D. Schmidt, Y. Yang, B. Zhang, S. Phogat, et al. “Structures of HIV-1 Quaternary-Structure-Preferring Antibodies, CH04 And PG9, Show Conserved Structural Elements Within a Generallly Flexible CDR H3.” In Aids Research and Human Retroviruses, 27:A118–19. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Whittle, James R. R., Ruijun Zhang, Surender Khurana, Lisa R. King, Jody Manischewitz, Hana Golding, Philip R. Dormitzer, et al. “Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.” Proc Natl Acad Sci U S A 108, no. 34 (August 23, 2011): 14216–21. https://doi.org/10.1073/pnas.1111497108.

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Gray, Elin S., M Anthony Moody, Constantinos Kurt Wibmer, Xi Chen, Dawn Marshall, Joshua Amos, Penny L. Moore, et al. “Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individual.” J Virol 85, no. 15 (August 2011): 7719–29. https://doi.org/10.1128/JVI.00563-11.

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Ferrari, Guido, Justin Pollara, Daniel Kozink, Tiara Harms, Mark Drinker, Stephanie Freel, M Anthony Moody, et al. “An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum.” J Virol 85, no. 14 (July 2011): 7029–36. https://doi.org/10.1128/JVI.00171-11.

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Verkoczy, Laurent, Garnett Kelsoe, M Anthony Moody, and Barton F. Haynes. “Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies.” Curr Opin Immunol 23, no. 3 (June 2011): 383–90. https://doi.org/10.1016/j.coi.2011.04.003.

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Haynes, Barton F., M Anthony Moody, Hua-Xin Liao, Laurent Verkoczy, and Georgia D. Tomaras. “B cell responses to HIV-1 infection and vaccination: pathways to preventing infection.” Trends Mol Med 17, no. 2 (February 2011): 108–16. https://doi.org/10.1016/j.molmed.2010.10.008.

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Moody, M Anthony, Ruijun Zhang, Emmanuel B. Walter, Christopher W. Woods, Geoffrey S. Ginsburg, Micah T. McClain, Thomas N. Denny, et al. “H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.” Plos One 6, no. 10 (2011): e25797. https://doi.org/10.1371/journal.pone.0025797.

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Morris, Lynn, Xi Chen, Munir Alam, Georgia Tomaras, Ruijun Zhang, Dawn J. Marshall, Bing Chen, et al. “Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting.” Plos One 6, no. 9 (2011): e23532. https://doi.org/10.1371/journal.pone.0023532.

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Alter, Galit, and M Anthony Moody. “The humoral response to HIV-1: new insights, renewed focus.” J Infect Dis 202 Suppl 2 (October 15, 2010): S315–22. https://doi.org/10.1086/655654.

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