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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and Assistant Professor of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza, syphilis, autoimmunity, and is interested in applying the technique to other disease processes.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Ferdman, Jack, Giuseppe Palladino, Hua-Xin Liao, M Anthony Moody, Thomas B. Kepler, Giuseppe Del Giudice, Philip R. Dormitzer, Stephen C. Harrison, Ethan C. Settembre, and Pirada Suphaphiphat. “Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine..” Vaccine 36, no. 35 (August 23, 2018): 5325–32. https://doi.org/10.1016/j.vaccine.2018.06.054.

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Moody, M Anthony. “Strength through Organization: Classifying Antibody Activity against EBOV..” Cell Host Microbe 24, no. 2 (August 8, 2018): 185–86. https://doi.org/10.1016/j.chom.2018.07.015.

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Madani, Navid, Amy M. Princiotto, Linh Mach, Shilei Ding, Jérémie Prevost, Jonathan Richard, Bhavna Hora, et al. “A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge..” Nat Commun 9, no. 1 (June 18, 2018). https://doi.org/10.1038/s41467-018-04758-9.

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Pardi, Norbert, Michael J. Hogan, Martin S. Naradikian, Kaela Parkhouse, Derek W. Cain, Letitia Jones, M Anthony Moody, et al. “Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses..” J Exp Med 215, no. 6 (June 4, 2018): 1571–88. https://doi.org/10.1084/jem.20171450.

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DeKosky, Brandon J., Bo Wang, Morgan Timm, Jiwon Lee, Erica Normandin, John Misasi, Rui Kong, et al. “Functional Interrogation and Mining of Natively-Paired Human V-H:V-L Antibody Repertoires.” In Journal of Immunology, Vol. 200. AMER ASSOC IMMUNOLOGISTS, 2018.

Scholars@Duke

Wills, Saintedym, Kwan-Ki Hwang, Pinghuang Liu, S Moses Dennison, Matthew Zirui Tay, Xiaoying Shen, Justin Pollara, et al. “HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis..” J Virol 92, no. 7 (April 1, 2018). https://doi.org/10.1128/JVI.01552-17.

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Wang, Bo, Brandon J. DeKosky, Morgan R. Timm, Jiwon Lee, Erica Normandin, John Misasi, Rui Kong, et al. “Functional interrogation and mining of natively paired human VH:VL antibody repertoires..” Nat Biotechnol 36, no. 2 (February 2018): 152–55. https://doi.org/10.1038/nbt.4052.

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Raymond, Donald D., Goran Bajic, Jack Ferdman, Pirada Suphaphiphat, Ethan C. Settembre, M Anthony Moody, Aaron G. Schmidt, and Stephen C. Harrison. “Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody..” Proc Natl Acad Sci U S A 115, no. 1 (January 2, 2018): 168–73. https://doi.org/10.1073/pnas.1715471115.

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Blasi, Maria, Donatella Negri, Celia LaBranche, S Munir Alam, Erich J. Baker, Elizabeth C. Brunner, Morgan A. Gladden, et al. “IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells..” Commun Biol 1 (2018). https://doi.org/10.1038/s42003-018-0131-6.

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Saunders, Kevin O., Laurent K. Verkoczy, Chuancang Jiang, Jinsong Zhang, Robert Parks, Haiyan Chen, Max Housman, et al. “Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models..” Cell Rep 21, no. 13 (December 26, 2017): 3681–90. https://doi.org/10.1016/j.celrep.2017.12.028.

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