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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and Assistant Professor of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza, syphilis, autoimmunity, and is interested in applying the technique to other disease processes.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Krebs, SJ, Kwon, YD, Schramm, CA, Law, WH, Donofrio, G, Zhou, KH, Gift, S, Dussupt, V, Georgiev, IS, Schätzle, S, McDaniel, JR, Lai, Y-T, Sastry, M, Zhang, B, Jarosinski, MC, Ransier, A, Chenine, AL, Asokan, M, Bailer, RT, Bose, M, Cagigi, A, Cale, EM, Chuang, G-Y, Darko, S, Driscoll, JI, Druz, A, Gorman, J, Laboune, F, Louder, MK, McKee, K, Mendez, L, Moody, MA, O'Sullivan, AM, Owen, C, Peng, D, Rawi, R, Sanders-Buell, E, Shen, C-H, Shiakolas, AR, Stephens, T, Tsybovsky, Y, Tucker, C, Verardi, R, Wang, K, Zhou, J, Zhou, T, Georgiou, G, Alam, SM, Haynes, BF, Rolland, M, Matyas, GR, Polonis, VR, McDermott, AB, Douek, DC, Shapiro, L, Tovanabutra, S, Michael, NL, Mascola, JR, Robb, ML, Kwong, PD, and Doria-Rose, NA. "Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual." Immunity 50, no. 3 (March 12, 2019): 677-691.e13.

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Bonsignori, M, Scott, E, Wiehe, K, Easterhoff, D, Alam, SM, Hwang, K-K, Cooper, M, Xia, S-M, Zhang, R, Montefiori, DC, Henderson, R, Nie, X, Kelsoe, G, Moody, MA, Chen, X, Joyce, MG, Kwong, PD, Connors, M, Mascola, JR, McGuire, AT, Stamatatos, L, Medina-Ramírez, M, Sanders, RW, Saunders, KO, Kepler, TB, and Haynes, BF. "Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier." Immunity 49, no. 6 (December 11, 2018): 1162-1174.e8.

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van Eeden, C, Wibmer, CK, Scheepers, C, Richardson, SI, Nonyane, M, Lambson, B, Mkhize, NN, Vijayakumar, B, Sheng, Z, Stanfield-Oakley, S, Bhiman, JN, Bekker, V, Hermanus, T, Mabvakure, B, Ismail, A, Moody, MA, Wiehe, K, Garrett, N, Karim, SA, Dirr, H, Fernandes, MA, Sayed, Y, Shapiro, L, Ferrari, G, Haynes, BF, Moore, PL, and Morris, L. "V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity." Cell Reports 25, no. 11 (December 2018): 3123-3135.e6.

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Williams, WB, Meyerhoff, RR, Li, H, Acharya, P, Stewart-Jones, GBE, Wiehe, K, Kepler, TB, Bradley, T, Bonsignori, M, Moody, MA, Saunders, KO, Santra, S, Kelsoe, G, Hraber, P, Korber, B, Hahn, BH, Kwong, P, Mascola, JR, Shaw, GM, and Haynes, BF. "Macaque SHIV Induction of 2G12-like Broadly Neutralizing Antibodies." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Bradley, T, Peppa, D, Pedroza-Pacheco, I, Li, D, Cain, DW, Henao, R, Venkat, V, Hora, B, Chen, Y, Vandergrift, NA, Overman, RG, Edwards, RW, Woods, CW, Tomaras, GD, Ferrari, G, Ginsburg, GS, Connors, M, Cohen, MS, Moody, MA, Borrow, P, and Haynes, BF. "RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses." Cell 175, no. 2 (October 2018): 387-399.e17.

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Fortner, KB, Swamy, GK, Broder, KR, Jimenez-Truque, N, Zhu, Y, Moro, PL, Liang, J, Walter, EB, Heine, RP, Moody, MA, Yoder, S, and Edwards, KM. "Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women." Vaccine 36, no. 42 (October 2018): 6354-6360.

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Van, V, Tolbert, W, Lewis, GK, Moody, MA, Pazgier, M, and Sherburn, R. "Structural Basis for A32-like Epitopes Involved in ADCC Response of the RV114 Vaccine Trial." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Ferdman, J, Palladino, G, Liao, H-X, Moody, MA, Kepler, TB, Del Giudice, G, Dormitzer, PR, Harrison, SC, Settembre, EC, and Suphaphiphat, P. "Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine." Vaccine 36, no. 35 (August 2018): 5325-5332.

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Moody, MA. "Strength through Organization: Classifying Antibody Activity against EBOV." Cell Host & Microbe 24, no. 2 (August 2018): 185-186.

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Madani, N, Princiotto, AM, Mach, L, Ding, S, Prevost, J, Richard, J, Hora, B, Sutherland, L, Zhao, CA, Conn, BP, Bradley, T, Moody, MA, Melillo, B, Finzi, A, Haynes, BF, Smith Iii, AB, Santra, S, and Sodroski, J. "A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge." Nature Communications 9, no. 1 (June 18, 2018): 2363-null.

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