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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and Assistant Professor of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza, syphilis, autoimmunity, and is interested in applying the technique to other disease processes.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Wills, S, Hwang, K-K, Liu, P, Dennison, SM, Zirui Tay, M, Shen, X, Pollara, J, Lucas, JT, Parks, R, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Thomas, R, Kim, JH, Michael, NL, Robb, ML, McRaven, M, Montefiori, DC, Hope, TJ, Liao, H-X, Moody, MA, Ferrari, G, Haynes, BF, Alam, SM, Bonsignori, M, and Tomaras, GD. "HIV-1 specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galcer Blocking and Phagocytosis." Journal of virology (January 10, 2018).

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Raymond, DD, Bajic, G, Ferdman, J, Suphaphiphat, P, Settembre, EC, Moody, MA, Schmidt, AG, and Harrison, SC. "Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody." Proceedings of the National Academy of Sciences of the United States of America 115, no. 1 (January 2018): 168-173.

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Saunders, KO, Verkoczy, LK, Jiang, C, Zhang, J, Parks, R, Chen, H, Housman, M, Bouton-Verville, H, Shen, X, Trama, AM, Scearce, R, Sutherland, L, Santra, S, Newman, A, Eaton, A, Xu, K, Georgiev, IS, Joyce, MG, Tomaras, GD, Bonsignori, M, Reed, SG, Salazar, A, Mascola, JR, Moody, MA, Cain, DW, Centlivre, M, Zurawski, S, Zurawski, G, Erickson, HP, Kwong, PD, Alam, SM, Levy, Y, Montefiori, DC, and Haynes, BF. "Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models." Cell reports 21, no. 13 (December 2017): 3681-3690.

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Williams, WB, Zhang, J, Jiang, C, Nicely, NI, Fera, D, Luo, K, Moody, MA, Liao, H-X, Alam, SM, Kepler, TB, Ramesh, A, Wiehe, K, Holland, JA, Bradley, T, Vandergrift, N, Saunders, KO, Parks, R, Foulger, A, Xia, S-M, Bonsignori, M, Montefiori, DC, Louder, M, Eaton, A, Santra, S, Scearce, R, Sutherland, L, Newman, A, Bouton-Verville, H, Bowman, C, Bomze, H, Gao, F, Marshall, DJ, Whitesides, JF, Nie, X, Kelsoe, G, Reed, SG, Fox, CB, Clary, K, Koutsoukos, M, Franco, D, Mascola, JR, and Harrison, SC et al. "Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations." Nature communications 8, no. 1 (November 23, 2017): 1732-.

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Mohr, EL, Dudley, DM, Aliota, MT, Weiler, A, Lehrer-Brey, G, Weisgrau, KL, Mohns, MS, Breitbach, ME, Rasheed, MN, Gellerup, DD, Moncla, LH, Post, J, Schultz-Darken, N, Schotkzo, ML, Hayes, JM, Eudailey, JA, Moody, MA, Permar, SR, O'Connor, SL, Rakasz, EG, Simmons, HA, III, CS, Golos, TG, Osorio, JE, Friedrich, TC, and O'Connor, DH. "DEVELOPMENT OF A NONHUMAN PRIMATE MODEL OF ZIKA VIRUS INFECTION IN PREGNANT AND NON-PREGNANT RHESUS MACAQUES." November 2017.

Scholars@Duke

Han, Q, Williams, WB, Saunders, KO, Seaton, KE, Wiehe, KJ, Vandergrift, N, Von Holle, TA, Trama, AM, Parks, RJ, Luo, K, Gurley, TC, Kepler, TB, Marshall, DJ, Montefiori, DC, Sutherland, LL, Alam, MS, Whitesides, JF, Bowman, CM, Permar, SR, Graham, BS, Mascola, JR, Seed, PC, Van Rompay, KKA, Tomaras, GD, Moody, MA, and Haynes, BF. "HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques." Journal of virology 91, no. 21 (November 2017).

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Phillips, B, Fouda, GG, Eudailey, J, Pollara, J, Curtis, AD, Kunz, E, Dennis, M, Shen, X, Bay, C, Hudgens, M, Pickup, D, Alam, SM, Ardeshir, A, Kozlowski, PA, Van Rompay, KKA, Ferrari, G, Moody, MA, Permar, S, and De Paris, K. "Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques." Clinical and vaccine immunology : CVI 24, no. 10 (October 2017).

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Wang, K, Tomaras, GD, Jegaskanda, S, Moody, MA, Liao, H-X, Goodman, KN, Berman, PW, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Haynes, BF, and Cohen, JI. "Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1." Journal of virology 91, no. 19 (October 2017).

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Bradley, T, Pollara, J, Santra, S, Vandergrift, N, Pittala, S, Bailey-Kellogg, C, Shen, X, Parks, R, Goodman, D, Eaton, A, Balachandran, H, Mach, LV, Saunders, KO, Weiner, JA, Scearce, R, Sutherland, LL, Phogat, S, Tartaglia, J, Reed, SG, Hu, S-L, Theis, JF, Pinter, A, Montefiori, DC, Kepler, TB, Peachman, KK, Rao, M, Michael, NL, Suscovich, TJ, Alter, G, Ackerman, ME, Moody, MA, Liao, H-X, Tomaras, G, Ferrari, G, Korber, BT, and Haynes, BF. "Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge." Nature communications 8 (June 8, 2017): 15711-.

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Saleh, E, Swamy, GK, Moody, MA, and Walter, EB. "Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study." Clinical pediatrics 56, no. 5 (May 2017): 435-442.

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