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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and the Department of Immunology at Duke University Medical Center. Research in the Moody lab is focused on understanding the B cell responses during infection, vaccination, and disease. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at the Duke Human Vaccine Institute (DHVI). The Moody lab is currently funded to study influenza, syphilis, HIV-1, and emerging infectious diseases.

Dr. Moody is the director of the Duke CIVICs Vaccine Center (DCVC) at (DHVI) and co-director of the Centers for Research of Emerging Infectious Disease Coordinating Center (CREID-CC). Dr. Moody is co-PI of a U19 program to develop a syphilis vaccine; this program is led by Dr. Justin Radolf at the University of Connecticut. Dr. Moody is also the director of the DHVI Accessioning Unit, a biorepository that provides support for work occurring at DHVI and with its many collaborators around the world by providing processing, shipping, and inventory support for a wide array of projects.

Dr. Moody and his team are involved in many networks studying vaccine response including the Collaborative Influenza Vaccine Innovation Centers (CIVICs), HIV Vaccine Trials Network (HVTN) and the COVID-19 Prevention Network (CoVPN).

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Tolbert, William D., Verna Van, Rebekah Sherburn, Marina Tuyishime, Fang Yan, Dung N. Nguyen, Sherry Stanfield-Oakley, et al. “Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial.” Mbio 11, no. 3 (June 30, 2020). https://doi.org/10.1128/mBio.00208-20.

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Hompe, Eliza D., Jesse F. Mangold, Amit Kumar, Joshua A. Eudailey, Erin McGuire, Barton F. Haynes, M Anthony Moody, et al. “Induction of Neutralizing Responses against Autologous Virus in Maternal HIV Vaccine Trials.” Msphere 5, no. 3 (June 3, 2020). https://doi.org/10.1128/mSphere.00254-20.

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Martinez, David R., Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, et al. “Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.” Mbio 11, no. 2 (March 10, 2020). https://doi.org/10.1128/mBio.00176-20.

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Jones, Letitia D., M Anthony Moody, and Amelia B. Thompson. “Innovations in HIV-1 Vaccine Design.” Clin Ther 42, no. 3 (March 2020): 499–514. https://doi.org/10.1016/j.clinthera.2020.01.009.

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Martinez, David R., Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, et al. “Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.” Mbio 11, no. 2 (March 1, 2020). https://doi.org/10.1128/mBio.00176.20.

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Bradley, Todd, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, et al. “Immune checkpoint modulation enhances HIV-1 antibody induction.” Nat Commun 11, no. 1 (February 19, 2020): 948. https://doi.org/10.1038/s41467-020-14670-w.

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Roskin, Krishna M., Katherine J. L. Jackson, Ji-Yeun Lee, Ramona A. Hoh, Shilpa A. Joshi, Kwan-Ki Hwang, Mattia Bonsignori, et al. “Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth.” Nat Immunol 21, no. 2 (February 2020): 199–209. https://doi.org/10.1038/s41590-019-0581-0.

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Easterhoff, David, Justin Pollara, Kan Luo, William D. Tolbert, Brianna Young, Dieter Mielke, Shalini Jha, et al. “Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.” J Virol 94, no. 4 (January 31, 2020). https://doi.org/10.1128/JVI.01120-19.

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Blasi, Maria, Elizabeth C. Wescott, Erich J. Baker, Benjamin Mildenberg, Celia LaBranche, Wes Rountree, Barton F. Haynes, et al. “Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques.” Npj Vaccines 5 (2020): 36. https://doi.org/10.1038/s41541-020-0186-5.

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Nyanhete, Tinashe E., Alyse L. Frisbee, Todd Bradley, William J. Faison, Elizabeth Robins, Tamika Payne, Stephanie A. Freel, et al. “HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.” Sci Rep 9, no. 1 (July 15, 2019): 10165. https://doi.org/10.1038/s41598-019-46462-8.

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