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Matthew Kelly, MD

Assistant Professor of Pediatrics
Assistant Research Professor of Global Health
Campus mail: 2301 Erwin Rd, Durham, NC 27710
Phone: (919) 684-6335
Email address: msk37@dm.duke.edu

My research is broadly focused on elucidating the complex interactions that exist between the host microbiome and exogenous pathogens that cause infections in children. We have several ongoing projects evaluating: 1) the impact of the upper respiratory microbiome on the risk of colonization and invasion by bacterial respiratory pathogens among infants in Botswana; 2) associations between the gut microbiome of pediatric stem cell transplant recipients and the risk of infections (bloodstream infection, C. difficile infection) and graft-versus-host disease; and 3) the role of the gut and respiratory microbiomes in mediating COVID-19 infection susceptibility and disease severity in children. Ultimately, I aim to develop strategies that use targeted modification of the microbiome for the prevention of infections in children.

Education and Training

  • Pediatric Infectious Diseases Fellowship, Pediatrics, Duke University School of Medicine, 2013 - 2016
  • David N. Pincus Pediatric Global Health Fellowship, Pediatrics, Children's Hospital of Philadelphia, 2011 - 2013
  • Internship/Residency, Pediatrics, Children's Hospital Boston, 2007 - 2010
  • M.D., Harvard Medical School, 2007
  • M.P.H., Harvard University , 2007

Selected Grants and Awards

Publications

Congdon, Morgan, Hwanhee Hong, Rebecca R. Young, Coleen K. Cunningham, Leslie A. Enane, Tonya Arscott-Mills, Francis M. Banda, et al. “Effect of Haemophilus influenzae Type b and 13-Valent Pneumococcal Conjugate Vaccines on Childhood Pneumonia Hospitalizations and Deaths in Botswana.” Clin Infect Dis 73, no. 2 (July 15, 2021): e410–16. https://doi.org/10.1093/cid/ciaa919.

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Garrido, Carolina, Jillian H. Hurst, Cynthia G. Lorang, Jhoanna N. Aquino, Javier Rodriguez, Trevor S. Pfeiffer, Tulika Singh, et al. “Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.” Jci Insight, July 6, 2021. https://doi.org/10.1172/jci.insight.150909.

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Bohannon, Lauren, Helen Tang, Kristin Page, Yi Ren, Sin-Ho Jung, Alexandra Artica, Anne Britt, et al. “Decreased Mortality in 1-Year Survivors of Umbilical Cord Blood Transplant vs. Matched Related or Matched Unrelated Donor Transplant in Patients with Hematologic Malignancies.” Transplant Cell Ther, May 12, 2021. https://doi.org/10.1016/j.jtct.2021.05.002.

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Garrido, Carolina, Jillian H. Hurst, Cynthia G. Lorang, Jhoanna N. Aquino, Javier Rodriguez, Trevor S. Pfeiffer, Tulika Singh, et al. “Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.” Medrxiv, April 20, 2021. https://doi.org/10.1101/2021.04.17.21255663.

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McClain, Micah T., Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, et al. “Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.” Nat Commun 12, no. 1 (February 17, 2021): 1079. https://doi.org/10.1038/s41467-021-21289-y.

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Elgarten, Caitlin W., Yimei Li, Kelly D. Getz, Michael Hemmer, Yuan-Shung V. Huang, Matthew Hall, Tao Wang, et al. “Broad-Spectrum Antibiotics and Risk of Graft-versus-Host Disease in Pediatric Patients Undergoing Transplantation for Acute Leukemia: Association of Carbapenem Use with the Risk of Acute Graft-versus-Host Disease.” Transplant Cell Ther 27, no. 2 (February 2021): 177.e1-177.e8. https://doi.org/10.1016/j.jtct.2020.10.012.

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Singh, Tulika, Sarah M. Heston, Stephanie N. Langel, Maria Blasi, Jillian H. Hurst, Genevieve G. Fouda, Matthew S. Kelly, and Sallie R. Permar. “Lessons From COVID-19 in Children: Key Hypotheses to Guide Preventative and Therapeutic Strategies.” Clin Infect Dis 71, no. 8 (November 5, 2020): 2006–13. https://doi.org/10.1093/cid/ciaa547.

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Hurst, Jillian H., Sarah M. Heston, Hailey N. Chambers, Hannah M. Cunningham, Meghan J. Price, Lilianna Suarez, Carter G. Crew, et al. “SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study.” Clin Infect Dis, November 3, 2020. https://doi.org/10.1093/cid/ciaa1693.

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Tanaka, John S., Rebecca R. Young, Sarah M. Heston, Kirsten Jenkins, Lisa P. Spees, Anthony D. Sung, Kelly Corbet, et al. “Anaerobic Antibiotics and the Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.” Biol Blood Marrow Transplant 26, no. 11 (November 2020): 2053–60. https://doi.org/10.1016/j.bbmt.2020.07.011.

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Heston, Sarah M., Rebecca R. Young, Hwanhee Hong, Ibukunoluwa C. Akinboyo, John S. Tanaka, Paul L. Martin, Richard Vinesett, et al. “Microbiology of Bloodstream Infections in Children After Hematopoietic Stem Cell Transplantation: A Single-Center Experience Over Two Decades (1997-2017).” Open Forum Infect Dis 7, no. 11 (November 2020): ofaa465. https://doi.org/10.1093/ofid/ofaa465.

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