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Matthew Kelly, MD

Assistant Professor of Pediatrics
Assistant Professor of Global Health
Campus mail: 2301 Erwin Rd, Durham, NC 27710
Phone: (919) 684-6335
Email address: msk37@dm.duke.edu

My research is broadly focused on elucidating the complex interactions that exist between the host microbiome and exogenous pathogens that cause infections in children. We have several ongoing projects evaluating: 1) the impact of the upper respiratory microbiome on the risk of colonization and invasion by bacterial respiratory pathogens among infants in Botswana; 2) associations between the gut microbiome of pediatric stem cell transplant recipients and the risk of infections (bloodstream infection, C. difficile infection) and graft-versus-host disease; and 3) the role of the gut and respiratory microbiomes in mediating COVID-19 infection susceptibility and disease severity in children. Ultimately, I aim to develop strategies that use targeted modification of the microbiome for the prevention of infections in children.

Education and Training

  • Pediatric Infectious Diseases Fellowship, Pediatrics, Duke University School of Medicine, 2013 - 2016
  • David N. Pincus Pediatric Global Health Fellowship, Pediatrics, Children's Hospital of Philadelphia, 2011 - 2013
  • Internship/Residency, Pediatrics, Children's Hospital Boston, 2007 - 2010
  • M.D., Harvard Medical School, 2007
  • M.P.H., Harvard University , 2007

Selected Grants and Awards

Publications

McClain, Micah T., Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, et al. “Dysregulated transcriptional responses to SARS-CoV-2 in the periphery support novel diagnostic approaches.” Medrxiv, July 26, 2020. https://doi.org/10.1101/2020.07.20.20155507.

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Tanaka, John S., Rebecca R. Young, Sarah M. Heston, Kirsten Jenkins, Lisa P. Spees, Anthony D. Sung, Kelly Corbet, et al. “Anaerobic Antibiotics and the Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.” Biol Blood Marrow Transplant, July 17, 2020. https://doi.org/10.1016/j.bbmt.2020.07.011.

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Patel, Sweta M., Sabelle Jallow, Sefelani Boiditswe, Shabir A. Madhi, Kristen A. Feemster, Andrew P. Steenhoff, Tonya Arscott-Mills, et al. “Placental Transfer of Respiratory Syncytial Virus Antibody Among HIV-Exposed, Uninfected Infants.” J Pediatric Infect Dis Soc 9, no. 3 (July 13, 2020): 349–56. https://doi.org/10.1093/jpids/piz056.

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Congdon, Morgan, Hwanhee Hong, Rebecca R. Young, Coleen K. Cunningham, Leslie A. Enane, Tonya Arscott-Mills, Francis M. Banda, et al. “Effect of Haemophilus influenzae type b and 13-valent pneumococcal conjugate vaccines on childhood pneumonia hospitalizations and deaths in Botswana.” Clin Infect Dis, July 8, 2020. https://doi.org/10.1093/cid/ciaa919.

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Young, Rebecca R., Kirsten Jenkins, Felix Araujo-Perez, Patrick C. Seed, and Matthew S. Kelly. “Long-term stability of microbiome diversity and composition in fecal samples stored in eNAT medium.” Microbiologyopen 9, no. 7 (July 2020): e1046. https://doi.org/10.1002/mbo3.1046.

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Fawole, Oluwatunmise A., Matthew S. Kelly, Andrew P. Steenhoff, Kristen A. Feemster, Eric J. Crotty, Mantosh S. Rattan, Thuso David, et al. “Interpretation of pediatric chest radiographs by non-radiologist clinicians in Botswana using World Health Organization criteria for endpoint pneumonia.” Pediatr Radiol 50, no. 7 (June 2020): 913–22. https://doi.org/10.1007/s00247-020-04625-0.

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Singh, Tulika, Sarah M. Heston, Stephanie N. Langel, Maria Blasi, Jillian H. Hurst, Genevieve G. Fouda, Matthew S. Kelly, and Sallie R. Permar. “Lessons from COVID-19 in children: Key hypotheses to guide preventative and therapeutic strategies.” Clin Infect Dis, May 8, 2020. https://doi.org/10.1093/cid/ciaa547.

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Liang, Guanxiang, Chunyu Zhao, Huanjia Zhang, Lisa Mattei, Scott Sherrill-Mix, Kyle Bittinger, Lyanna R. Kessler, et al. “The stepwise assembly of the neonatal virome is modulated by breastfeeding.” Nature 581, no. 7809 (May 2020): 470–74. https://doi.org/10.1038/s41586-020-2192-1.

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Akinboyo, Ibukunoluwa C., Rebecca R. Young, Lisa P. Spees, Sarah M. Heston, Michael J. Smith, Yeh-Chung Chang, Lauren E. McGill, et al. “Microbiology and Risk Factors for Hospital-Associated Bloodstream Infections Among Pediatric Hematopoietic Stem Cell Transplant Recipients.” Open Forum Infect Dis 7, no. 4 (April 2020): ofaa093. https://doi.org/10.1093/ofid/ofaa093.

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Weimer, Kristin E. D., Matthew S. Kelly, Sallie R. Permar, Reese H. Clark, and Rachel G. Greenberg. “Association of Adverse Hearing, Growth, and Discharge Age Outcomes With Postnatal Cytomegalovirus Infection in Infants With Very Low Birth Weight.” Jama Pediatr 174, no. 2 (February 1, 2020): 133–40. https://doi.org/10.1001/jamapediatrics.2019.4532.

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