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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 70 of the most commonly used medicines in children. Each of these trials is conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.

The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.

Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows, and multiple junior faculty. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to secure their own funding.

Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 500 recreation league, travel league, and scholastic baseball games and he is the head coach of Smith Middle School, the 5-year reigning southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged school-aged boys and girls.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina - Chapel Hill, 2003
  • M.P.H., University of North Carolina - Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Gonzalez, Daniel, James M. Chamberlain, Jeffrey T. Guptill, Michael Cohen-Wolkowiez, Barrie Harper, Jian Zhao, Edmund V. Capparelli, and Edmund V. Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. “Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus.” Clin Pharmacokinet 56, no. 8 (August 2017): 941–51. https://doi.org/10.1007/s40262-016-0486-0.

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Wynn, James L., Matthew S. Kelly, Daniel K. Benjamin, Reese H. Clark, Rachel Greenberg, and P Brian Smith. “Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis.” Am J Perinatol 34, no. 7 (June 2017): 633–39. https://doi.org/10.1055/s-0036-1597130.

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Ward, Robert M., Daniel Benjamin, Jeffrey S. Barrett, Karel Allegaert, Ronald Portman, Jonathan M. Davis, and Mark A. Turner. “Safety, dosing, and pharmaceutical quality for studies that evaluate medicinal products (including biological products) in neonates.” In Pediatr Res, 81:692–711, 2017. https://doi.org/10.1038/pr.2016.221.

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Lee, Jin A., Brooke Sauer, William Tuminski, Jiyu Cheong, John Fitz-Henley, Megan Mayers, Chidera Ezuma-Igwe, et al. “Effectiveness of Granulocyte Colony-Stimulating Factor in Hospitalized Infants with Neutropenia.” Am J Perinatol 34, no. 5 (April 2017): 458–64. https://doi.org/10.1055/s-0036-1593349.

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Smith, Michael J., Daniel Gonzalez, Jennifer L. Goldman, Ram Yogev, Janice E. Sullivan, Michael D. Reed, Ravinder Anand, et al. “Pharmacokinetics of Clindamycin in Obese and Nonobese Children.” Antimicrob Agents Chemother 61, no. 4 (April 2017). https://doi.org/10.1128/AAC.02014-16.

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Ericson, Jessica E., Martyn Gostelow, Julie Autmizguine, Christoph P. Hornik, Reese H. Clark, Daniel K. Benjamin, P Brian Smith, and P Brian Pediatric Trials Network Executive Committee and Investigators. “Safety of High-dose Acyclovir in Infants With Suspected and Confirmed Neonatal Herpes Simplex Virus Infections.” Pediatr Infect Dis J 36, no. 4 (April 2017): 369–73. https://doi.org/10.1097/INF.0000000000001451.

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Zhang, Cecilia J., Martin Bidlingmaier, Mekibib Altaye, Laura C. Page, David D’Alessio, Matthias H. Tschöp, and Jenny Tong. “Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans.” Eur J Endocrinol 176, no. 2 (February 2017): 123–32. https://doi.org/10.1530/EJE-16-0789.

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Mankouski, Anastasiya, Crystal Kantores, Mathew J. Wong, Julijana Ivanovska, Amish Jain, Eric J. Benner, Stanley N. Mason, A Keith Tanswell, Richard L. Auten, and Robert P. Jankov. “Intermittent hypoxia during recovery from neonatal hyperoxic lung injury causes long-term impairment of alveolar development: A new rat model of BPD.” Am J Physiol Lung Cell Mol Physiol 312, no. 2 (February 1, 2017): L208–16. https://doi.org/10.1152/ajplung.00463.2016.

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Wang, Laura A., Daniel Gonzalez, J Steven Leeder, Rachel F. Tyndale, Robin E. Pearce, Daniel K. Benjamin, Gregory L. Kearns, Michael Cohen-Wolkowiez, and Michael Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. “Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.” J Clin Pharmacol 57, no. 2 (February 2017): 230–34. https://doi.org/10.1002/jcph.797.

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Parente, V., R. H. Clark, L. Ku, C. Fennell, M. Johnson, E. Morris, A. Romaine, et al. “Risk factors for group B streptococcal disease in neonates of mothers with negative antenatal testing.” J Perinatol 37, no. 2 (February 2017): 157–61. https://doi.org/10.1038/jp.2016.201.

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