Skip to main content

Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 70 of the most commonly used medicines in children. Each of these trials is conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.

The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.

Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows, and multiple junior faculty. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to secure their own funding.

Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 500 recreation league, travel league, and scholastic baseball games and he is the head coach of Smith Middle School, the 5-year reigning southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged school-aged boys and girls.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina - Chapel Hill, 2003
  • M.P.H., University of North Carolina - Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Benjamin, D. K. “Contracting for health and safety: Risk perception and rational choice.” In Cutting Green Tape: Pollutants, Environmental Regulation and the Law, 223–50, 2018.

Scholars@Duke

Le, Jennifer, Brenda Poindexter, Janice E. Sullivan, Matthew Laughon, Paula Delmore, Martha Blackford, Ram Yogev, et al. “Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates.” Ther Drug Monit 40, no. 1 (February 2018): 103–8. https://doi.org/10.1097/FTD.0000000000000466.

Full Text

Testoni, Daniela, Christoph P. Hornik, Ruth Guinsburg, Reese H. Clark, Rachel G. Greenberg, Daniel K. Benjamin, and P Brian Smith. “Early lumbar puncture and risk of intraventricular hemorrhage in very low birth weight infants.” Early Hum Dev 117 (February 2018): 1–6. https://doi.org/10.1016/j.earlhumdev.2017.11.013.

Full Text

Shakhnovich, Valentina, P Brian Smith, Jeffrey T. Guptill, Laura P. James, David N. Collier, Huali Wu, Chad E. Livingston, Jian Zhao, Gregory L. Kearns, and Gregory L. Best Pharmaceuticals for Children Act – Pediatric Trials Network. “Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures.” J Pediatr 193 (February 2018): 102-108.e1. https://doi.org/10.1016/j.jpeds.2017.10.011.

Full Text

Ericson, J. E., and D. K. Benjamin. “Clinical Approach to the Infected Neonate.” In Principles and Practice of Pediatric Infectious Diseases, 547-549.e1, 2018. https://doi.org/10.1016/B978-0-323-40181-4.00091-8.

Full Text

Watt, Kevin M., Debbie Avant, Jennifer Sherwin, Daniel K. Benjamin, Christoph Hornik, Jennifer S. Li, and P Brian Smith. “Effect of renal function on antihypertensive drug safety and efficacy in children.” Pediatr Nephrol 33, no. 1 (January 2018): 139–46. https://doi.org/10.1007/s00467-017-3763-8.

Full Text

Zimmerman, K., and D. K. Benjamin. “Necrotizing Enterocolitis.” In Principles and Practice of Pediatric Infectious Diseases, 394-397.e2, 2018. https://doi.org/10.1016/B978-0-323-40181-4.00058-X.

Full Text

Ward, Robert M., Daniel K. Benjamin, Jonathan M. Davis, Richard L. Gorman, Ralph Kauffman, Gregory L. Kearns, Mary Dianne Murphy, and Catherine M. T. Sherwin. “The Need for Pediatric Drug Development.” J Pediatr 192 (January 2018): 13–21. https://doi.org/10.1016/j.jpeds.2017.08.011.

Full Text

Hwang, Michael F., Ryan J. Beechinor, Kelly C. Wade, Daniel K. Benjamin, P Brian Smith, Christoph P. Hornik, Edmund V. Capparelli, et al. “External Evaluation of Two Fluconazole Infant Population Pharmacokinetic Models.” Antimicrob Agents Chemother 61, no. 12 (December 2017). https://doi.org/10.1128/AAC.01352-17.

Full Text

Watt, Kevin M., Michael Cohen-Wolkowiez, Duane C. Williams, Desiree K. Bonadonna, Ira M. Cheifetz, Dhiren Thakker, Daniel K. Benjamin, and Kim L. R. Brouwer. “Antifungal Extraction by the Extracorporeal Membrane Oxygenation Circuit.” J Extra Corpor Technol 49, no. 3 (September 2017): 150–59.

Scholars@Duke

Pages