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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor of Pediatrics
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 50 of the most commonly used medicines in children. Each of these trials is conducted under an investigational new drug (IND) application with guidance from the Food and Drug Administration for labeling.

Signature programs of the Network include clinical trials in premature, term infants and most recently, obese children. Over the past 10 years, Dr. Benjamin’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Dr. Benjamin is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Dr. Benjamin’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows (including two T32 programs sponsored by NIH for which he is PI), and multiple junior faculty.

Dr. Benjamin has published over 250 works with up to 7000 citations. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina at Chapel Hill, 2003
  • M.P.H., University of North Carolina at Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Zhang, Cecilia J., Martin Bidlingmaier, Mekibib Altaye, Laura C. Page, David D’Alessio, Matthias H. Tschöp, and Jenny Tong. “Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans.” Eur J Endocrinol 176, no. 2 (February 2017): 123–32. https://doi.org/10.1530/EJE-16-0789.

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Mankouski, Anastasiya, Crystal Kantores, Mathew J. Wong, Julijana Ivanovska, Amish Jain, Eric J. Benner, Stanley N. Mason, A Keith Tanswell, Richard L. Auten, and Robert P. Jankov. “Intermittent hypoxia during recovery from neonatal hyperoxic lung injury causes long-term impairment of alveolar development: A new rat model of BPD.” Am J Physiol Lung Cell Mol Physiol 312, no. 2 (February 1, 2017): L208–16. https://doi.org/10.1152/ajplung.00463.2016.

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Wang, Laura A., Daniel Gonzalez, J Steven Leeder, Rachel F. Tyndale, Robin E. Pearce, Daniel K. Benjamin, Gregory L. Kearns, Michael Cohen-Wolkowiez, and Michael Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. “Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.” J Clin Pharmacol 57, no. 2 (February 2017): 230–34. https://doi.org/10.1002/jcph.797.

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Parente, V., R. H. Clark, L. Ku, C. Fennell, M. Johnson, E. Morris, A. Romaine, et al. “Risk factors for group B streptococcal disease in neonates of mothers with negative antenatal testing.” J Perinatol 37, no. 2 (February 2017): 157–61. https://doi.org/10.1038/jp.2016.201.

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Lloyd, Jessica C., Christoph P. Hornik, Daniel K. Benjamin, Reese H. Clark, Jonathan C. Routh, and P Brian Smith. “Incidence of Breakthrough Urinary Tract Infection in Hospitalized Infants Receiving Antibiotic Prophylaxis.” Clin Pediatr (Phila) 56, no. 1 (January 2017): 65–70. https://doi.org/10.1177/0009922816638664.

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Smith, P Brian, Daniel K. Benjamin, and Ann M. Reed. “The Role of a Division of Quantitative Sciences Division in Enhancing Academic Productivity of a Department of Pediatrics.” J Pediatr 180 (January 2017): 4–5. https://doi.org/10.1016/j.jpeds.2016.09.042.

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Hornik, Christoph P., Daniel K. Benjamin, P Brian Smith, Michael J. Pencina, Adriana H. Tremoulet, Edmund V. Capparelli, Jessica E. Ericson, Reese H. Clark, Michael Cohen-Wolkowiez, and Michael Best Pharmaceuticals for Children Act—Pediatric Trials Network. “Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates.” J Pediatr 178 (November 2016): 125-129.e1. https://doi.org/10.1016/j.jpeds.2016.07.011.

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Autmizguine, Julie, Christoph P. Hornik, Daniel K. Benjamin, Kim L. R. Brouwer, Susan R. Hupp, Michael Cohen-Wolkowiez, and Kevin M. Watt. “Pharmacokinetics and Safety of Micafungin in Infants Supported With Extracorporeal Membrane Oxygenation.” Pediatr Infect Dis J 35, no. 11 (November 2016): 1204–10. https://doi.org/10.1097/INF.0000000000001268.

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Zimmerman, Kanecia, Martin Putera, Christoph P. Hornik, P. Brian Smith, Daniel K. Benjamin, Yeruk Mulugeta, Gilbert J. Burckart, Michael Cohen-Wolkowiez, and Daniel Gonzalez. “Exposure Matching of Pediatric Anti-infective Drugs: Review of Drugs Submitted to the Food and Drug Administration for Pediatric Approval.” Clin Ther 38, no. 9 (September 2016): 1995–2005. https://doi.org/10.1016/j.clinthera.2016.06.003.

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Ericson, Jessica E., David A. Kaufman, Stephen D. Kicklighter, Jatinder Bhatia, Daniela Testoni, Jamie Gao, P Brian Smith, et al. “Fluconazole Prophylaxis for the Prevention of Candidiasis in Premature Infants: A Meta-analysis Using Patient-level Data.” Clin Infect Dis 63, no. 5 (September 1, 2016): 604–10. https://doi.org/10.1093/cid/ciw363.

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