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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 70 of the most commonly used medicines in children. Each of these trials is conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.

The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.

Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows, and multiple junior faculty. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to secure their own funding.

Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 500 recreation league, travel league, and scholastic baseball games and he is the head coach of Smith Middle School, the 5-year reigning southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged school-aged boys and girls.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina - Chapel Hill, 2003
  • M.P.H., University of North Carolina - Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Thaden, Joshua T., Karen Chiswell, Ian Jaffe, Stephen P. Bergin, William E. Yang, Andrew Romaine, Jamie Roberts, et al. “Pediatric Antibacterial and Antifungal Trials From 2007 to 2017.” Pediatrics 142, no. 3 (September 2018). https://doi.org/10.1542/peds.2017-1849.

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Bernard, Gordon R., Paul A. Harris, Jill M. Pulley, Daniel K. Benjamin, Jonathan Michael, Daniel E. Ford, Daniel F. Hanley, Harry P. Selker, and Consuelo H. Wilkins. “A collaborative, academic approach to optimizing the national clinical research infrastructure: The first year of the Trial Innovation Network.” J Clin Transl Sci 2, no. 4 (August 2018): 187–92. https://doi.org/10.1017/cts.2018.319.

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Ariagno, Ronald L., Henry C. Lee, David K. Stevenson, Daniel K. Benjamin, P Brian Smith, Marilyn B. Escobedo, and Dilip R. Bhatt. “A directory for neonatal intensive care: potential for facilitating network-based research in neonatology.” J Perinatol 38, no. 8 (August 2018): 954–58. https://doi.org/10.1038/s41372-018-0097-8.

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Gonzalez, Daniel, Laura P. James, Amira Al-Uzri, Miroslava Bosheva, Felice C. Adler-Shohet, Susan R. Mendley, John S. Bradley, et al. “Population Pharmacokinetics and Safety of Solithromycin following Intravenous and Oral Administration in Infants, Children, and Adolescents.” Antimicrobial Agents and Chemotherapy 62, no. 8 (August 1, 2018). https://doi.org/10.1128/AAC.00692-18;e00692-18.

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Gonzalez, Daniel, Laura P. James, Amira Al-Uzri, Miroslava Bosheva, Felice C. Adler-Shohet, Susan R. Mendley, John S. Bradley, et al. “Population Pharmacokinetics and Safety of Solithromycin following Intravenous and Oral Administration in Infants, Children, and Adolescents.” Antimicrob Agents Chemother 62, no. 8 (August 2018). https://doi.org/10.1128/AAC.00692-18.

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Kovanda, Laura L., Thomas J. Walsh, Daniel K. Benjamin, Antonio Arrieta, David A. Kaufman, P Brian Smith, Paolo Manzoni, et al. “Exposure-Response Analysis of Micafungin in Neonatal Candidiasis: Pooled Analysis of Two Clinical Trials.” Pediatr Infect Dis J 37, no. 6 (June 2018): 580–85. https://doi.org/10.1097/INF.0000000000001957.

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Smith, Brian, Susan Knox, and Daniel K. Benjamin. “Coordination of the Environmental influences on Child Health Outcomes program: so the whole is greater than the sum of its parts.” Curr Opin Pediatr 30, no. 2 (April 2018): 263–68. https://doi.org/10.1097/MOP.0000000000000598.

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Corneli, Amy, Chris Wheeler, John Bradley, Breck Gamel, Sumathi Nambiar, Gary J. Noel, Li Lin, Jamie N. Roberts, and Daniel K. Benjamin. “Facilitators and barriers to the successful implementation of pediatric antibacterial drug trials: Findings from CTTI's survey of investigators.” Contemp Clin Trials Commun 9 (March 2018): 115–20. https://doi.org/10.1016/j.conctc.2018.01.003.

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Greenberg, Rachel G., Breck Gamel, Diane Bloom, John Bradley, Hasan S. Jafri, Denise Hinton, Sumathi Nambiar, et al. “Parents' perceived obstacles to pediatric clinical trial participation: Findings from the clinical trials transformation initiative.” Contemp Clin Trials Commun 9 (March 2018): 33–39. https://doi.org/10.1016/j.conctc.2017.11.005.

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Greenberg, Rachel G., Amy Corneli, John Bradley, John Farley, Hasan S. Jafri, Li Lin, Sumathi Nambiar, et al. “Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative.” Contemp Clin Trials Commun 9 (March 2018): 7–12. https://doi.org/10.1016/j.conctc.2017.11.006.

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