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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 70 of the most commonly used medicines in children. Each of these trials is conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.

The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.

Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows, and multiple junior faculty. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to secure their own funding.

Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 500 recreation league, travel league, and scholastic baseball games and he is the head coach of Smith Middle School, the 5-year reigning southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged school-aged boys and girls.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina - Chapel Hill, 2003
  • M.P.H., University of North Carolina - Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Kumar, Karan R., David A. Clark, Evan M. Kim, Jasmine D. Perry, Kaylyn Wright, Sheikisha A. Thomas, Elizabeth J. Thompson, et al. “Association of Atrial Septal Defects and Bronchopulmonary Dysplasia in Premature Infants.” J Pediatr 202 (November 2018): 56-62.e2. https://doi.org/10.1016/j.jpeds.2018.07.024.

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Steinbach, William J., Daniel K. Benjamin, and John W. Sleasman. “Funding Pediatric Subspecialty Training: Are T32 Grants the Future?” J Pediatr 202 (November 2018): 4-7.e1. https://doi.org/10.1016/j.jpeds.2018.08.035.

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Ku, Lawrence C., Christoph P. Hornik, Ryan J. Beechinor, James M. Chamberlain, Jeffrey T. Guptill, Barrie Harper, Edmund V. Capparelli, et al. “Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus.” Cpt Pharmacometrics Syst Pharmacol 7, no. 11 (November 2018): 718–27. https://doi.org/10.1002/psp4.12349.

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Romaine, Andrew, Reese H. Clark, Briana R. Davis, Kaitlin Hendershot, Vance Kite, Madeleine Laughon, Isaac Updike, et al. “Predictors of Prolonged Breast Milk Provision to Very Low Birth Weight Infants.” J Pediatr 202 (November 2018): 23-30.e1. https://doi.org/10.1016/j.jpeds.2018.07.001.

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Gray, Keyaria D., Kathryn Dudash, Carla Escobar, Colman Freel, Tylah Harrison, Chandler McMillan, Mihai Puia-Dumitrescu, et al. “Prevalence and safety of diazoxide in the neonatal intensive care unit.” J Perinatol 38, no. 11 (November 2018): 1496–1502. https://doi.org/10.1038/s41372-018-0218-4.

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Benjamin, Daniel K., David A. Kaufman, William W. Hope, P Brian Smith, Antonio Arrieta, Paolo Manzoni, Laura L. Kovanda, et al. “A Phase 3 Study of Micafungin Versus Amphotericin B Deoxycholate in Infants With Invasive Candidiasis.” Pediatr Infect Dis J 37, no. 10 (October 2018): 992–98. https://doi.org/10.1097/INF.0000000000001996.

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Shakhnovich, Valentina, P. Brian Smith, Jeffrey T. Guptill, Laura P. James, David N. Collier, Huali Wu, Chad E. Livingston, et al. “A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents.” Paediatr Drugs 20, no. 5 (October 2018): 483–95. https://doi.org/10.1007/s40272-018-0305-1.

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Wang, Laura A., P Brian Smith, Matthew Laughon, Ronald N. Goldberg, Lawrence C. Ku, Kanecia O. Zimmerman, Stephen Balevic, et al. “Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants.” Early Hum Dev 125 (October 2018): 26–30. https://doi.org/10.1016/j.earlhumdev.2018.08.009.

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Tsakiri, Sophia, Chiamaka Aneji, Christine Domonoske, Lynnette Mazur, Daniel K. Benjamin, and Susan H. Wootton. “Voriconazole Treatment for an Infant With Intractable Candida glabrata Meningitis.” Pediatr Infect Dis J 37, no. 10 (October 2018): 999–1001. https://doi.org/10.1097/INF.0000000000002073.

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Autmizguine, Julie, Sylvia Tan, Michael Cohen-Wolkowiez, C Michael Cotten, Nathan Wiederhold, Ronald N. Goldberg, Ira Adams-Chapman, et al. “Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis.” Pediatr Infect Dis J 37, no. 9 (September 2018): 923–29. https://doi.org/10.1097/INF.0000000000001913.

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