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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 70 of the most commonly used medicines in children. Each of these trials is conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.

The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.

Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows, and multiple junior faculty. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to secure their own funding.

Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 500 recreation league, travel league, and scholastic baseball games and he is the head coach of Smith Middle School, the 5-year reigning southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged school-aged boys and girls.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina - Chapel Hill, 2003
  • M.P.H., University of North Carolina - Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Benjamin, Daniel K., Elizabeth R. DeLong, Charles M. Cotten, Harmony P. Garges, and Reese H. Clark. “Postconception age and other risk factors associated with mortality following Gram-negative rod bacteremia.” J Perinatol 24, no. 3 (March 2004): 169–74. https://doi.org/10.1038/sj.jp.7211047.

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Miller, J. L., W. A. Schell, E. A. Wills, D. L. Toffaletti, M. Boyce, D. K. Benjamin, J. Bartroli, and J. R. Perfect. “In vitro and in vivo efficacies of the new triazole albaconazole against Cryptococcus neoformans.” Antimicrob Agents Chemother 48, no. 2 (February 2004): 384–87. https://doi.org/10.1128/aac.48.2.384-387.2004.

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Drew, Richard H., Elizabeth Dodds Ashley, Daniel K. Benjamin, R. Duane Davis, Scott M. Palmer, and John R. Perfect. “Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients.” Transplantation 77, no. 2 (January 27, 2004): 232–37. https://doi.org/10.1097/01.TP.0000101516.08327.A9.

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Benjamin, Daniel K., Jose M. Miro, Bruno Hoen, William J. Steinbach, Vance G. Fowler, Lars Olaison, Gilbert Habib, et al. “Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD).” Scand J Infect Dis 36, no. 6–7 (2004): 453–55. https://doi.org/10.1080/00365540410020703.

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Benjamin, D. K., W. C. Miller, R. W. Ryder, D. J. Weber, E. Walter, and R. E. McKinney. “Growth patterns reflect response to antiretroviral therapy in HIV-positive infants: potential utility in resource-poor settings.” Aids Patient Care Stds 18, no. 1 (January 2004): 35–43. https://doi.org/10.1089/108729104322740901.

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Benjamin, Daniel K., Elizabeth DeLong, and William J. Steinbach. “Latent class analysis: an illustrative application for education in the assessment of resident otoscopic skills.” Ambul Pediatr 4, no. 1 (January 2004): 13–17. https://doi.org/10.1367/1539-4409(2004)004<0013:lcaaia>2.0.co;2.

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Benjamin, Daniel K., Wiliam C. Miller, Robert W. Ryder, David J. Weber, Emmanuel Walter, and Ross E. McKinney. “A comparison of height and weight velocity as a part of the composite endpoint in pediatric HIV.” Aids 17, no. 16 (November 7, 2003): 2331–36. https://doi.org/10.1097/00002030-200311070-00007.

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Benjamin, Daniel K., Harmony Garges, and William J. Steinbach. “Candida bloodstream infection in neonates.” Semin Perinatol 27, no. 5 (October 2003): 375–83. https://doi.org/10.1016/s0146-0005(03)00061-2.

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Weintrob, Amy C., Julieta Giner, Prema Menezes, Ericka Patrick, Daniel Kelly Benjamin, Jeffrey Lennox, Christopher D. Pilcher, Joseph J. Eron, and Charles B. Hicks. “Infrequent diagnosis of primary human immunodeficiency virus infection: missed opportunities in acute care settings.” Arch Intern Med 163, no. 17 (September 22, 2003): 2097–2100. https://doi.org/10.1001/archinte.163.17.2097.

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Benjamin, Daniel K., Elizabeth R. DeLong, William J. Steinbach, Charles M. Cotton, Thomas J. Walsh, and Reese H. Clark. “Empirical therapy for neonatal candidemia in very low birth weight infants.” Pediatrics 112, no. 3 Pt 1 (September 2003): 543–47. https://doi.org/10.1542/peds.112.3.543.

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