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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor of Pediatrics
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 50 of the most commonly used medicines in children. Each of these trials is conducted under an investigational new drug (IND) application with guidance from the Food and Drug Administration for labeling.

Signature programs of the Network include clinical trials in premature, term infants and most recently, obese children. Over the past 10 years, Dr. Benjamin’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Dr. Benjamin is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Dr. Benjamin’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows (including two T32 programs sponsored by NIH for which he is PI), and multiple junior faculty.

Dr. Benjamin has published over 250 works with up to 7000 citations. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina at Chapel Hill, 2003
  • M.P.H., University of North Carolina at Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards


Calland, J Forrest, Reid B. Adams, Daniel K. Benjamin, Matthew J. O’Connor, Vinay Chandrasekhara, Stephanie Guerlain, and Rayford Scott Jones. “Thirty-day postoperative death rate at an academic medical center.” Ann Surg 235, no. 5 (May 2002): 690–96.

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Benjamin, D. K. “Integration of statistical theory and practical clinical expertise. Polymerase chain reaction testing of the HIV-exposed infant.” Minerva Pediatr 54, no. 2 (April 2002): 105–11.


Dyke, C. K., D. K. Benjamin, C. L. Nelson, K. Newby, C. O’shea, W. Cantor, C. Nguyen, J. H. Alexander, M. M. Kitt, and J. E. Tcheng. “Elevated troponin following percutaneous coronary intervention predicts subsequent events: Results from the ESPRIT trial.” Journal of the American College of Cardiology 39, no. 5 (March 6, 2002): 72A-72A.


Benjamin, Daniel Kelly, William C. Miller, Sherry Bayliff, Lisa Martel, Kenneth A. Alexander, and Paul Langlie Martin. “Infections diagnosed in the first year after pediatric stem cell transplantation.” Pediatr Infect Dis J 21, no. 3 (March 2002): 227–34.

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Benjamin, D. K., W. C. Miller, S. A. Fiscus, M. Morse, M. Valentine, and R. E. McKinney. “Rational testing of the HIV-exposed infant.” Pediatrics 108, no. 1 (July 2001): E3.

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Benjamin, D. K., W. Miller, H. Garges, R. E. McKinney, M. Cotton, R. G. Fisher, and K. A. Alexander. “Bacteremia, central catheters, and neonates: when to pull the line.” Pediatrics 107, no. 6 (June 2001): 1272–76.

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Benjamin, D. K., K. Ross, R. E. McKinney, R. Auten, and R. G. Fisher. “When to suspect fungal infection in neonates: A clinical comparison of Candida albicans and Candida parapsilosis fungemia with coagulase-negative staphylococcal bacteremia.” Pediatrics 106, no. 4 (October 2000): 712–18.

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Benjamin, D. K., R. G. Fisher, and R. E. McKinney. “Candidal mycetoma in the neonatal kidney.” Pediatrics 104, no. 5 Pt 1 (November 1999): 1126–29.

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