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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 70 of the most commonly used medicines in children. Each of these trials is conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.

The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.

Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows, and multiple junior faculty. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to secure their own funding.

Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 500 recreation league, travel league, and scholastic baseball games and he is the head coach of Smith Middle School, the 5-year reigning southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged school-aged boys and girls.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina - Chapel Hill, 2003
  • M.P.H., University of North Carolina - Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Boutzoukas, Angelique E., Kanecia O. Zimmerman, Daniel K. Benjamin, Kevin J. Chick, Jake Curtiss, and Tracy Beth Høeg. “Quarantine Elimination for K-12 Students With Mask-on-Mask Exposure to SARS-CoV-2.” Pediatrics, November 4, 2021. https://doi.org/10.1542/peds.2021-054268L.

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Boutzoukas, Angelique E., Kanecia O. Zimmerman, Daniel K. Benjamin, Gregory P. DeMuri, Ibukunoluwa C. Kalu, Michael J. Smith, Kathleen A. McGann, Shawn Koval, M Alan Brookhart, and Sabrina M. Butteris. “Secondary Transmission of COVID-19 in K-12 Schools: Findings From Two States.” Pediatrics, November 4, 2021. https://doi.org/10.1542/peds.2021-054268K.

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Boutzoukas, Angelique E., Kanecia O. Zimmerman, Daniel K. Benjamin, and Daniel K. ABC Science Collaborative. “School Safety, Masking, and the Delta Variant.” Pediatrics, October 8, 2021. https://doi.org/10.1542/peds.2021-054396.

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Gerhart, Jacqueline G., Fernando O. Carreño, Andrea N. Edginton, Jaydeep Sinha, Eliana M. Perrin, Karan R. Kumar, Aruna Rikhi, et al. “Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling.” Clin Pharmacokinet, October 7, 2021. https://doi.org/10.1007/s40262-021-01072-4.

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Zimmerman, Kanecia O., M Alan Brookhart, Ibukunoluwa C. Kalu, Angelique E. Boutzoukas, Kathleen A. McGann, Michael J. Smith, Gabriela M. Maradiaga Panayotti, et al. “Community SARS-CoV-2 Surge and Within-School Transmission.” Pediatrics 148, no. 4 (October 2021). https://doi.org/10.1542/peds.2021-052686.

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Stark, Ashley, P Brian Smith, Christoph P. Hornik, Kanecia O. Zimmerman, Chi D. Hornik, Sidart Pradeep, Reese H. Clark, Daniel K. Benjamin, Matthew Laughon, and Rachel G. Greenberg. “Medication Use in the Neonatal Intensive Care Unit and Changes from 2010 to 2018.” J Pediatr, September 2, 2021. https://doi.org/10.1016/j.jpeds.2021.08.075.

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Maharaj, Anil R., Huali Wu, Kanecia O. Zimmerman, William J. Muller, Janice E. Sullivan, Catherine M. T. Sherwin, Julie Autmizguine, et al. “Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity.” Paediatr Drugs 23, no. 5 (September 2021): 499–513. https://doi.org/10.1007/s40272-021-00460-4.

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Miller, Laura E., Chris DeRienzo, P Brian Smith, Carl Bose, Reese H. Clark, C Michael Cotten, Daniel K. Benjamin, Chi D. Hornik, and Rachel G. Greenberg. “Association between neonatal intensive care unit medication safety practices, adverse events, and death.” Journal of Perinatology : Official Journal of the California Perinatal Association 41, no. 7 (July 2021): 1739–44. https://doi.org/10.1038/s41372-020-00857-y.

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Lyall, Kristen, Mina Hosseini, Christine Ladd-Acosta, Xuejuan Ning, Diane Catellier, John N. Constantino, Lisa A. Croen, et al. “Distributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research.” J Autism Dev Disord 51, no. 7 (July 2021): 2241–53. https://doi.org/10.1007/s10803-020-04667-1.

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Smith, Michael J., Angelique Boutzoukas, Julie Autmizguine, Mark L. Hudak, Erin Zinkhan, Barry T. Bloom, Gloria Heresi, et al. “Antibiotic Safety and Effectiveness in Premature Infants With Complicated Intraabdominal Infections.” Pediatr Infect Dis J 40, no. 6 (June 1, 2021): 550–55. https://doi.org/10.1097/INF.0000000000003034.

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