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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Professor of Pediatrics
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 50 of the most commonly used medicines in children. Each of these trials is conducted under an investigational new drug (IND) application with guidance from the Food and Drug Administration for labeling.

Signature programs of the Network include clinical trials in premature, term infants and most recently, obese children. Over the past 10 years, Dr. Benjamin’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Dr. Benjamin is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Dr. Benjamin’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows (including two T32 programs sponsored by NIH for which he is PI), and multiple junior faculty.

Dr. Benjamin has published over 250 works with up to 7000 citations. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina at Chapel Hill, 2003
  • M.P.H., University of North Carolina at Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Hornik, Christoph P., Amy A. Gelfand, Christina L. Szperka, Tara Pezzuto, Amanda Utevsky, Shirley Kessel, Susan McCune, John J. Alexander, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Development of a Prospective Real-World Data Clinical Registry of Children and Adolescents With Migraine..” Headache, November 22, 2019. https://doi.org/10.1111/head.13714.

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Petraitis, Vidmantas, Ruta Petraitiene, Jessica M. Valdez, Vasilios Pyrgos, Martin J. Lizak, Brenda A. Klaunberg, Darius Kalasauskas, et al. “Amphotericin B Penetrates into the Central Nervous System Through Focal Disruption of the Blood Brain Barrier in Experimental Hematogenous Candida Meningoencephalitis..” Antimicrob Agents Chemother, October 7, 2019. https://doi.org/10.1128/AAC.01626-19.

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Thompson, Elizabeth J., Huali Wu, Chiara Melloni, Stephen Balevic, Janice E. Sullivan, Matthew Laughon, Kira M. Clark, et al. “Population Pharmacokinetics of Doxycycline in Children..” Antimicrob Agents Chemother, September 23, 2019. https://doi.org/10.1128/AAC.01508-19.

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Balevic, Stephen J., P Brian Smith, Daniela Testoni, Huali Wu, Kim L. R. Brouwer, Kanecia O. Zimmerman, Nazario D. Rivera-Chaparro, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Cefazolin pharmacokinetics in premature infants..” J Perinatol 39, no. 9 (September 2019): 1213–18. https://doi.org/10.1038/s41372-019-0368-z.

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Puia-Dumitrescu, Mihai, P Brian Smith, Jian Zhao, Angela Soriano, Elizabeth H. Payne, Barrie Harper, Ellen Bendel-Stenzel, et al. “Dosing and Safety of Off-label Use of Caffeine Citrate in Premature Infants..” J Pediatr 211 (August 2019): 27-32.e1. https://doi.org/10.1016/j.jpeds.2019.04.028.

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Zimmerman, Kanecia O., Daniel K. Benjamin, and Mara L. Becker. “Neonatal Therapeutics: Considerations for Dosing..” Am J Perinatol 36, no. S 02 (July 2019): S18–21. https://doi.org/10.1055/s-0039-1691772.

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Gerhart, Jacqueline G., Kevin M. Watt, Andrea Edginton, Kelly C. Wade, Sara N. Salerno, Daniel K. Benjamin, P Brian Smith, et al. “Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants..” In Cpt Pharmacometrics Syst Pharmacol, 8:500–510, 2019. https://doi.org/10.1002/psp4.12414.

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Smith, P Brian, C Michael Cotten, Mark L. Hudak, Janice E. Sullivan, Brenda B. Poindexter, Michael Cohen-Wolkowiez, Felix Boakye-Agyeman, et al. “Rifampin Pharmacokinetics and Safety in Preterm and Term Infants..” Antimicrob Agents Chemother 63, no. 6 (June 2019). https://doi.org/10.1128/AAC.00284-19.

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Greenberg, Rachel G., Sreepriya Gayam, Destiny Savage, Andrew Tong, Daniel Gorham, Ari Sholomon, Reese H. Clark, et al. “Furosemide Exposure and Prevention of Bronchopulmonary Dysplasia in Premature Infants..” J Pediatr 208 (May 2019): 134-140.e2. https://doi.org/10.1016/j.jpeds.2018.11.043.

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Watt, Kevin M., Christoph P. Hornik, Stephen J. Balevic, Gratias Mundakel, C Michael Cotten, Barrie Harper, Daniel K. Benjamin, et al. “Pharmacokinetics of ticarcillin-clavulanate in premature infants..” Br J Clin Pharmacol 85, no. 5 (May 2019): 1021–27. https://doi.org/10.1111/bcp.13882.

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