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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 70 of the most commonly used medicines in children. Each of these trials is conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.

The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.

Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows, and multiple junior faculty. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to secure their own funding.

Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 500 recreation league, travel league, and scholastic baseball games and he is the head coach of Smith Middle School, the 5-year reigning southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged school-aged boys and girls.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina - Chapel Hill, 2003
  • M.P.H., University of North Carolina - Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Commander, Sarah Jane, Jamie Gao, Erin K. Zinkhan, Gloria Heresi, Sherry E. Courtney, Adrian P. Lavery, Paula Delmore, et al. “Safety of Metronidazole in Late Pre-term and Term Infants with Complicated Intra-abdominal Infections.” Pediatr Infect Dis J 39, no. 9 (September 2020): e245–48. https://doi.org/10.1097/INF.0000000000002698.

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Stark, Ashley, Julie Childers, Morgan England, Reese H. Clark, Matthew Laughon, Michael Cohen-Wolkowiez, Daniel K. Benjamin, P Brian Smith, Kelly Wade, and Rachel G. Greenberg. “Dosing of Antimicrobials in the Neonatal Intensive Care Unit: Does Clinical Practice Reflect Pharmacokinetics-based Recommendations?” Pediatr Infect Dis J 39, no. 8 (August 2020): 713–17. https://doi.org/10.1097/INF.0000000000002657.

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Ericson, Jessica E., John McGuire, Marian G. Michaels, Adam Schwarz, Robert Frenck, Jaime G. Deville, Swati Agarwal, et al. “Hospital-acquired Pneumonia and Ventilator-associated Pneumonia in Children: A Prospective Natural History and Case-Control Study.” Pediatr Infect Dis J 39, no. 8 (August 2020): 658–64. https://doi.org/10.1097/INF.0000000000002642.

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Jackson, Wesley, Genevieve Taylor, Nicolas A. Bamat, Kanecia Zimmerman, Reese Clark, Daniel K. Benjamin, Matthew M. Laughon, Rachel G. Greenberg, and Christoph P. Hornik. “Outcomes associated with surfactant in more mature and larger premature infants with respiratory distress syndrome.” J Perinatol 40, no. 8 (August 2020): 1171–77. https://doi.org/10.1038/s41372-020-0625-1.

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Ericson, Jessica E., Christoph P. Hornik, Rachel G. Greenberg, Reese H. Clark, Adriana H. Tremoulet, Jennifer Le, Michael Cohen-Wolkowiez, P Brian Smith, Daniel K. Benjamin, and Daniel K. Best Pharmaceuticals for Children Act – Pediatric Trials Network. “Paradoxical Antibiotic Effect of Ampicillin: Use of a Population Pharmacokinetic Model to Evaluate a Clinical Correlate of the Eagle Effect in Infants With Bacteremia.” Pediatr Infect Dis J 39, no. 8 (August 2020): 725–29. https://doi.org/10.1097/INF.0000000000002663.

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Xie, Rujia, Lynn McFadyen, Susan Raber, Robert Swanson, Margaret Tawadrous, Heidi Leister-Tebbe, Michael Cohen-Wolkowiez, Daniel K. Benjamin, and Ping Liu. “Population Analysis of Anidulafungin in Infants to Older Adults With Confirmed or Suspected Invasive Candidiasis.” Clin Pharmacol Ther 108, no. 2 (August 2020): 316–25. https://doi.org/10.1002/cpt.1831.

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Salerno, Sara N., Andrea Edginton, Jacqueline G. Gerhart, Matthew M. Laughon, Namasivayam Ambalavanan, Gregory M. Sokol, Chi D. Hornik, et al. “Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants.” Clin Pharmacol Ther, July 21, 2020. https://doi.org/10.1002/cpt.1990.

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Gray, Keyaria D., Julia A. Messina, Christopher Cortina, Tanasha Owens, Madeline Fowler, Matthew Foster, Simi Gbadegesin, et al. “Probiotic Use and Safety in the Neonatal Intensive Care Unit: A Matched Cohort Study.” J Pediatr 222 (July 2020): 59-64.e1. https://doi.org/10.1016/j.jpeds.2020.03.051.

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Maharaj, Anil R., Huali Wu, Christoph P. Hornik, Stephen J. Balevic, Chi D. Hornik, P Brian Smith, Daniel Gonzalez, et al. “Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019.” Jama Pediatr, June 5, 2020, e202422. https://doi.org/10.1001/jamapediatrics.2020.2422.

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Donoghue, Aaron J., Maybelle Kou, Grace L. Good, Carmel Eiger, Mark Nash, Fred M. Henretig, Helen Stacks, et al. “Impact of Personal Protective Equipment on Pediatric Cardiopulmonary Resuscitation Performance: A Controlled Trial.” Pediatr Emerg Care 36, no. 6 (June 2020): 267–73. https://doi.org/10.1097/PEC.0000000000002109.

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