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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 70 of the most commonly used medicines in children. Each of these trials is conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.

The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.

Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows, and multiple junior faculty. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to secure their own funding.

Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 500 recreation league, travel league, and scholastic baseball games and he is the head coach of Smith Middle School, the 5-year reigning southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged school-aged boys and girls.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina - Chapel Hill, 2003
  • M.P.H., University of North Carolina - Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Bekelman, T. A., S. L. Johnson, R. I. Steinberg, C. K. Martin, K. A. Sauder, S. Luckett-Cole, D. H. Glueck, et al. “A Qualitative Analysis of the Remote Food Photography Method and the Automated Self-Administered 24-hour Dietary Assessment Tool for Assessing Children's Food Intake Reported by Parent Proxy.” Journal of the Academy of Nutrition and Dietetics 122, no. 5 (May 1, 2022): 961–73. https://doi.org/10.1016/j.jand.2021.11.001.

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Thakkar, Pavan V., Kanecia O. Zimmerman, M Alan Brookhart, Tyler R. Erickson, Daniel K. Benjamin, Ibukunoluwa C. Kalu, and Ibukunoluwa C. ABC Science Collaborative. “COVID-19 Incidence Among Sixth Through Twelfth Grade Students by Vaccination Status.” Pediatrics 149, no. 5 (May 1, 2022). https://doi.org/10.1542/peds.2022-056230.

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Thakkar, Pavan V., Kanecia O. Zimmerman, Daniel K. Benjamin, and Ibukunoluwa C. Kalu. “SARS-CoV-2 Infections and Incidence at a North Carolina Pre-Kindergarten-12 School During In-Person Education: August 2020 to January 2021.” J Sch Health 92, no. 5 (May 2022): 461–68. https://doi.org/10.1111/josh.13148.

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Campbell, Melissa M., Daniel K. Benjamin, Tara Mann, Alex Fist, Hwasoon Kim, Laura Edwards, Zsolt Rak, et al. “Test-to-Stay After Exposure to SARS-CoV-2 in K-12 Schools.” Pediatrics 149, no. 5 (May 1, 2022). https://doi.org/10.1542/peds.2021-056045.

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Gerhart, Jacqueline G., Fernando O. Carreño, Matthew Shane Loop, Craig R. Lee, Andrea N. Edginton, Jaydeep Sinha, Karan R. Kumar, et al. “Use of Real-World Data and Physiologically-Based Pharmacokinetic Modeling to Characterize Enoxaparin Disposition in Children with Obesity.” Clin Pharmacol Ther, April 22, 2022. https://doi.org/10.1002/cpt.2618.

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Boutzoukas, Angelique E., Kanecia O. Zimmerman, Moira Inkelas, M Alan Brookhart, Daniel K. Benjamin, Sabrina Butteris, Shawn Koval, et al. “School Masking Policies and Secondary SARS-CoV-2 Transmission.” Pediatrics, March 9, 2022. https://doi.org/10.1542/peds.2022-056687.

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Zimmerman, Kanecia O., Brian Perry, Emily Hanlen-Rosado, Adora Nsonwu, Morgan D. Lane, Daniel K. Benjamin, Mara Becker, Amy Corneli, and Amy Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. “Developing lay summaries and thank you notes in paediatric pragmatic clinical trials.” Health Expect, March 4, 2022. https://doi.org/10.1111/hex.13448.

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Le, Jennifer, Rachel G. Greenberg, YoungJun Yoo, Reese H. Clark, Daniel K. Benjamin, Kanecia O. Zimmerman, Michael Cohen-Wolkowiez, Kelly C. Wade, and Kelly C. Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. “Ampicillin dosing in premature infants for early-onset sepsis: exposure-driven efficacy, safety, and stewardship.” J Perinatol, February 24, 2022. https://doi.org/10.1038/s41372-022-01344-2.

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Boutzoukas, Angelique E., Kanecia O. Zimmerman, Tara K. Mann, Ganga S. Moorthy, Ashley Blakemore, Kathleen A. McGann, Michael J. Smith, et al. “A School-Based SARS-CoV-2 Testing Program: Testing Uptake and Quarantine Length After In-School Exposures.” Pediatrics 149, no. 12 Suppl 2 (February 1, 2022). https://doi.org/10.1542/peds.2021-054268J.

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Zimmerman, Kanecia O., Jennifer L. Goldman, Jennifer E. Schuster, Atenas Mena, Margo Quiriconi, Sabrina M. Butteris, Shawn Koval, et al. “Building a National Framework to Pair Scientists and Schools During a Global Pandemic.” Pediatrics 149, no. Suppl 2 (February 1, 2022). https://doi.org/10.1542/peds.2021-054268D.

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