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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Professor of Pediatrics
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 50 of the most commonly used medicines in children. Each of these trials is conducted under an investigational new drug (IND) application with guidance from the Food and Drug Administration for labeling.

Signature programs of the Network include clinical trials in premature, term infants and most recently, obese children. Over the past 10 years, Dr. Benjamin’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Dr. Benjamin is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Dr. Benjamin’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows (including two T32 programs sponsored by NIH for which he is PI), and multiple junior faculty.

Dr. Benjamin has published over 250 works with up to 7000 citations. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina at Chapel Hill, 2003
  • M.P.H., University of North Carolina at Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Puia-Dumitrescu, M, Benjamin, DK, Smith, PB, Greenberg, RG, Abuzaid, N, Andrews, W, Chellani, K, Gupta, A, Price, D, Williams, C, Malcolm, WF, Clark, RH, and Zimmerman, KO. "Impact of Gastrostomy Tube Placement on Short-Term Weight Gain in Hospitalized Premature Infants." Jpen. Journal of Parenteral and Enteral Nutrition (March 25, 2019).

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Smith, PB, Cotten, CM, Hudak, ML, Sullivan, JE, Poindexter, BB, Cohen-Wolkowiez, M, Boakye-Agyeman, F, Lewandowski, A, Anand, R, Benjamin, DK, Laughon, MM, and Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee, . "Rifampin Pharmacokinetics and Safety in Preterm and Term Infants." Antimicrobial Agents and Chemotherapy (March 25, 2019).

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Watt, KM, Hornik, CP, Balevic, SJ, Mundakel, G, Cotten, CM, Harper, B, Benjamin, DK, Anand, R, Laughon, M, Smith, PB, Cohen-Wolkowiez, M, and Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee, . "Pharmacokinetics of ticarcillin-clavulanate in premature infants." British Journal of Clinical Pharmacology (February 2, 2019).

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Rivera-Chaparro, ND, Ericson, J, Wu, H, Smith, PB, Clark, RH, Benjamin, DK, Cohen-Wolkowiez, M, and Greenberg, RG. "Safety, Effectiveness and Exposure-response of Micafungin in Infants: Application of an Established Pharmacokinetics Model to Electronic Health Records." The Pediatric Infectious Disease Journal 38, no. 2 (February 2019): e26-e28.

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Cohen-Wolkowiez, M, and Benjamin, DK. "Development of Therapeutics for Children-A Tricky Balancing Act." Jama Pediatrics 173, no. 1 (January 2019): 18-19.

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Greenberg, RG, Gayam, S, Savage, D, Tong, A, Gorham, D, Sholomon, A, Clark, RH, Benjamin, DK, Laughon, M, Smith, PB, and Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee, . "Furosemide Exposure and Prevention of Bronchopulmonary Dysplasia in Premature Infants." The Journal of Pediatrics (December 20, 2018).

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Autmizguine, J, Smith, PB, Prather, K, Bendel, C, Natarajan, G, Bidegain, M, Kaufman, DA, Burchfield, DJ, Ross, AS, Pandit, P, Schell, WA, Gao, J, Benjamin, DK, and Fluconazole Prophylaxis Study Team, . "Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants." The Journal of Antimicrobial Chemotherapy 73, no. 12 (December 2018): 3482-3487.

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Puia-Dumitrescu, M, Bretzius, OM, Brown, N, Fitz-Henley, JA, Ssengonzi, R, Wechsler, CS, Gray, KD, Benjamin, DK, Smith, PB, Clark, RH, Gonzalez, D, and Hornik, CP. "Evaluation of Gentamicin Exposure in the Neonatal Intensive Care Unit and Hearing Function at Discharge." The Journal of Pediatrics 203 (December 2018): 131-136.

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Kumar, KR, Clark, DA, Kim, EM, Perry, JD, Wright, K, Thomas, SA, Thompson, EJ, Greenberg, RG, Smith, PB, Benjamin, DK, Laughon, MM, Clark, RH, and Hornik, CP. "Association of Atrial Septal Defects and Bronchopulmonary Dysplasia in Premature Infants." The Journal of Pediatrics 202 (November 2018): 56-62.e2.

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Steinbach, WJ, Benjamin, DK, and Sleasman, JW. "Funding Pediatric Subspecialty Training: Are T32 Grants the Future?." The Journal of Pediatrics 202 (November 2018): 4-7.e1.

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