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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Professor of Pediatrics
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 50 of the most commonly used medicines in children. Each of these trials is conducted under an investigational new drug (IND) application with guidance from the Food and Drug Administration for labeling.

Signature programs of the Network include clinical trials in premature, term infants and most recently, obese children. Over the past 10 years, Dr. Benjamin’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Dr. Benjamin is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Dr. Benjamin’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows (including two T32 programs sponsored by NIH for which he is PI), and multiple junior faculty.

Dr. Benjamin has published over 250 works with up to 7000 citations. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina at Chapel Hill, 2003
  • M.P.H., University of North Carolina at Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards


Greenberg, RG, Gamel, B, Bloom, D, Bradley, J, Jafri, HS, Hinton, D, Nambiar, S, Wheeler, C, Tiernan, R, Smith, PB, Roberts, J, and Benjamin, DK. "Parents' perceived obstacles to pediatric clinical trial participation: Findings from the clinical trials transformation initiative (Accepted)." Contemporary Clinical Trials Communications 9 (March 1, 2018): 33-39.

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Greenberg, RG, Corneli, A, Bradley, J, Farley, J, Jafri, HS, Lin, L, Nambiar, S, Noel, GJ, Wheeler, C, Tiernan, R, Smith, PB, Roberts, J, and Benjamin, DK. "Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative (Accepted)." Contemporary Clinical Trials Communications 9 (March 1, 2018): 7-12.

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Le, J, Poindexter, B, Sullivan, JE, Laughon, M, Delmore, P, Blackford, M, Yogev, R, James, LP, Melloni, C, Harper, B, Mitchell, J, Benjamin, DK, Boakye-Agyeman, F, and Cohen-Wolkowiez, M. "Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates. (Accepted)" Therapeutic drug monitoring 40, no. 1 (February 2018): 103-108.

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Watt, KM, Avant, D, Sherwin, J, Benjamin, DK, Hornik, C, Benjamin, DK, Li, JS, and Smith, PB. "Effect of renal function on antihypertensive drug safety and efficacy in children." Pediatric nephrology (Berlin, Germany) 33, no. 1 (January 2018): 139-146.

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Ward, RM, Benjamin, DK, Davis, JM, Gorman, RL, Kauffman, R, Kearns, GL, Murphy, MD, and Sherwin, CMT. "The Need for Pediatric Drug Development." The Journal of pediatrics 192 (January 2018): 13-21.

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Testoni, D, Hornik, CP, Guinsburg, R, Clark, RH, Greenberg, RG, Benjamin, DK, and Smith, PB. "Early lumbar puncture and risk of intraventricular hemorrhage in very low birth weight infants." Early human development 117 (December 5, 2017): 1-6.

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Hwang, MF, Beechinor, RJ, Wade, KC, Benjamin, DK, Smith, PB, Hornik, CP, Capparelli, EV, Duara, S, Kennedy, KA, Cohen-Wolkowiez, M, and Gonzalez, D. "External Evaluation of Two Fluconazole Infant Population Pharmacokinetic Models." Antimicrobial agents and chemotherapy 61, no. 12 (December 2017).

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Watt, KM, Cohen-Wolkowiez, M, Williams, DC, Bonadonna, DK, Cheifetz, IM, Thakker, D, Benjamin, DK, and Brouwer, KLR. "Antifungal Extraction by the Extracorporeal Membrane Oxygenation Circuit." The journal of extra-corporeal technology 49, no. 3 (September 2017): 150-159.


Gonzalez, D, Chamberlain, JM, Guptill, JT, Cohen-Wolkowiez, M, Harper, B, Zhao, J, Capparelli, EV, and Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee, . "Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus." Clinical pharmacokinetics 56, no. 8 (August 2017): 941-951.

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Wynn, JL, Kelly, MS, Benjamin, DK, Clark, RH, Greenberg, R, Benjamin, DK, and Smith, PB. "Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis." American journal of perinatology 34, no. 7 (June 2017): 633-639.

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