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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 70 of the most commonly used medicines in children. Each of these trials is conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.

The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.

Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows, and multiple junior faculty. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to secure their own funding.

Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 500 recreation league, travel league, and scholastic baseball games and he is the head coach of Smith Middle School, the 5-year reigning southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged school-aged boys and girls.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina - Chapel Hill, 2003
  • M.P.H., University of North Carolina - Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Aleem, Samia, Cliff Robbins, Brianna Murphy, Stephen Elliott, Christiana Akinyemi, Nicholas Paredes, Veeral N. Tolia, et al. “The use of supplemental hydrocortisone in the management of persistent pulmonary hypertension of the newborn.” J Perinatol, February 15, 2021. https://doi.org/10.1038/s41372-021-00943-9.

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Williams, Phoebe C. M., John Bradley, Emmanuel Roilides, Linus Olson, Sheldon Kaplan, Irja Lutsar, Carlo Giaquinto, Daniel K. Benjamin, and Mike Sharland. “Harmonising regulatory approval for antibiotics in children.” Lancet Child Adolesc Health 5, no. 2 (February 2021): 96–98. https://doi.org/10.1016/S2352-4642(20)30365-5.

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Le, Jennifer, Rachel G. Greenberg, Daniel K. Benjamin, YoungJun Yoo, Kanecia O. Zimmerman, Michael Cohen-Wolkowiez, Kelly C. Wade, and Kelly C. Administrative Core Committee of the Best Pharmaceuticals for Children Act–Pediatric Trials Network. “Prolonged Post-Discontinuation Antibiotic Exposure in Very Low Birth Weight Neonates at Risk for Early-Onset Sepsis.” J Pediatric Infect Dis Soc, January 25, 2021. https://doi.org/10.1093/jpids/piaa172.

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Zimmerman, Kanecia O., Ibukunoluwa C. Akinboyo, M Alan Brookhart, Angelique E. Boutzoukas, Kathleen McGann, Michael J. Smith, Gabriela Maradiaga Panayotti, et al. “Incidence and Secondary Transmission of SARS-CoV-2 Infections in Schools.” Pediatrics, January 8, 2021. https://doi.org/10.1542/peds.2020-048090.

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Polcwiartek, Laura Bech, P Brian Smith, Daniel K. Benjamin, Kanecia Zimmerman, Alycia Love, Lance Tiu, Sylvia Murray, et al. “Early-onset sepsis in term infants admitted to neonatal intensive care units (2011-2016).” J Perinatol 41, no. 1 (January 2021): 157–63. https://doi.org/10.1038/s41372-020-00860-3.

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Boutzoukas, Angelique E., Ibukunoluwa C. Akinboyo, Charlene A. Wong, Daniel K. Benjamin, and Kanecia O. Zimmerman. “Impact of COVID-19-related School Closures on the Drivers of Child Health.” N C Med J 82, no. 1 (January 2021): 50–56. https://doi.org/10.18043/ncm.82.1.50.

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Ge, Shufan, Susan R. Mendley, Jacqueline G. Gerhart, Chiara Melloni, Christoph P. Hornik, Janice E. Sullivan, Andrew Atz, et al. “Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents.” Clin Transl Sci 13, no. 6 (November 2020): 1189–98. https://doi.org/10.1111/cts.12803.

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Dorismond, Christina, Senyene E. Hunter, Peggy P. McNaull, Kanecia O. Zimmerman, Daniel K. Benjamin, Rachel G. Greenberg, Kristin M. Corey, Matthew M. Laughon, and Wesley M. Jackson. “Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants.” J Perinatol, October 23, 2020. https://doi.org/10.1038/s41372-020-00864-z.

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Miller, Laura E., Chris DeRienzo, P Brian Smith, Carl Bose, Reese H. Clark, C Michael Cotten, Daniel K. Benjamin, Chi D. Hornik, and Rachel G. Greenberg. “Association between neonatal intensive care unit medication safety practices, adverse events, and death.” J Perinatol, October 8, 2020. https://doi.org/10.1038/s41372-020-00857-y.

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Maharaj, Anil R., Huali Wu, Christoph P. Hornik, Stephen J. Balevic, Chi D. Hornik, P Brian Smith, Daniel Gonzalez, et al. “Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019.” Jama Pediatr 174, no. 10 (October 1, 2020): e202422. https://doi.org/10.1001/jamapediatrics.2020.2422.

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