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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Professor of Pediatrics
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 50 of the most commonly used medicines in children. Each of these trials is conducted under an investigational new drug (IND) application with guidance from the Food and Drug Administration for labeling.

Signature programs of the Network include clinical trials in premature, term infants and most recently, obese children. Over the past 10 years, Dr. Benjamin’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Dr. Benjamin is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Dr. Benjamin’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows (including two T32 programs sponsored by NIH for which he is PI), and multiple junior faculty.

Dr. Benjamin has published over 250 works with up to 7000 citations. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina at Chapel Hill, 2003
  • M.P.H., University of North Carolina at Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Kovanda, LL, Walsh, TJ, Benjamin, DK, Arrieta, A, Kaufman, DA, Smith, PB, Manzoni, P, Desai, AV, Kaibara, A, Bonate, PL, and Hope, WW. "Exposure-Response Analysis of Micafungin in Neonatal Candidiasis: Pooled Analysis of Two Clinical Trials." The Pediatric infectious disease journal 37, no. 6 (June 2018): 580-585.

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Tsakiri, S, Aneji, C, Domonoske, C, Mazur, L, Benjamin, DK, and Wootton, SH. "Voriconazole Treatment for an Infant with Intractable Candida Glabrata Meningitis." The Pediatric infectious disease journal (April 19, 2018).

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Smith, B, Knox, S, and Benjamin, DK. "Coordination of the Environmental influences on Child Health Outcomes program: so the whole is greater than the sum of its parts." Current opinion in pediatrics 30, no. 2 (April 2018): 263-268.

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Rivera-Chaparro, ND, Ericson, J, Wu, H, Smith, PB, Clark, RH, Benjamin, DK, Cohen-Wolkowiez, M, and Greenberg, RG. "Safety, Effectiveness, and Exposure-Response of Micafungin in Infants: Application of an Established Pharmacokinetics Model to Electronic Health Records." The Pediatric infectious disease journal (March 29, 2018).

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Ariagno, RL, Lee, HC, Stevenson, DK, Benjamin, DK, Smith, PB, Escobedo, MB, and Bhatt, DR. "A directory for neonatal intensive care: potential for facilitating network-based research in neonatology." Journal of perinatology : official journal of the California Perinatal Association (March 15, 2018).

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Corneli, A, Wheeler, C, Bradley, J, Gamel, B, Nambiar, S, Noel, GJ, Lin, L, Roberts, JN, and Benjamin, DK. "Facilitators and barriers to the successful implementation of pediatric antibacterial drug trials: Findings from CTTI's survey of investigators." Contemporary clinical trials communications 9 (March 2018): 115-120.

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Greenberg, RG, Gamel, B, Bloom, D, Bradley, J, Jafri, HS, Hinton, D, Nambiar, S, Wheeler, C, Tiernan, R, Smith, PB, Roberts, J, and Benjamin, DK. "Parents' perceived obstacles to pediatric clinical trial participation: Findings from the clinical trials transformation initiative." Contemporary clinical trials communications 9 (March 2018): 33-39.

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Greenberg, RG, Corneli, A, Bradley, J, Farley, J, Jafri, HS, Lin, L, Nambiar, S, Noel, GJ, Wheeler, C, Tiernan, R, Smith, PB, Roberts, J, and Benjamin, DK. "Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative." Contemporary clinical trials communications 9 (March 2018): 7-12.

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Gerhart, JG, Watt, KM, Edginton, A, Wade, KC, Jr, BDK, Smith, PB, Hornik, CP, Cohen-Wolkowiez, M, Duara, S, Ross, AS, Shattuck, K, Stewart, DL, Neu, N, and Gonzalez, D. "PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING OF FLUCONAZOLE USING PLASMA AND CEREBROSPINAL FLUID SAMPLES COLLECTED FROM PRETERM AND TERM INFANTS." March 2018.

Scholars@Duke

Le, J, Poindexter, B, Sullivan, JE, Laughon, M, Delmore, P, Blackford, M, Yogev, R, James, LP, Melloni, C, Harper, B, Mitchell, J, Benjamin, DK, Boakye-Agyeman, F, and Cohen-Wolkowiez, M. "Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates." Therapeutic drug monitoring 40, no. 1 (February 2018): 103-108.

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