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Ashlee R. Stiles, PhD

Assistant Professor of Pediatrics
Campus mail: 801-6 Capitola Dr, Durham, NC 27713
Email address: ashlee.stiles@duke.edu

Dr. Stiles is a fellow of the American College of Medical Genetics and Genomics trained in clinical biochemical genetics and molecular genetics. She is co-director of the Duke University Health System Biochemical Genetics Laboratory and external Referral Laboratory. In her work with the Biochemical Genetics laboratory, her research interests focus on improving and developing laboratory diagnostics for rare inborn errors of metabolism. In her role as director of the Referral laboratory, she works closely with hospital leadership on utilization management of genetic send-out tests. 

Education and Training

  • Ucla, University of California at Los Angeles, 2015 - 2016
  • Children's Hospital Of Orange County, University of California at Los Angeles, 2013 - 2015
  • Post-Doctoral Fellowship, Dept Of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 2012 - 2013
  • Ph.D., University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 2013

Publications

Young, Sarah, Haoyue Zhang, James Beasley, Patricia McCaw, Deeksha Bali, Seung-Hye Jung, Priya Kishnani, and Ashlee Stiles. “EVALUATION OF PLASMA GLUCOSYLSPHINGOSINE AND GALACTOSYLSPHINGOSINE IN PATIENTS WITH GAUCHER DISEASE.” In Molecular Genetics and Metabolism, 127:312–13. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019.

Scholars@Duke

Young, Sarah, Haoyue Zhang, James Beasley, Patricia McCaw, Deeksha Bali, Seung-Hye Jung, Priya Kishnani, and Ashlee Stiles. “EVALUATION OF PLASMA GLUCOSYLSPHINGOSINE AND GALACTOSYLSPHINGOSINE IN PATIENTS WITH GAUCHER DISEASE.” In Molecular Genetics and Metabolism, 126:336–336. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019.

Scholars@Duke

Stiles, Ashlee, Deeksha Bali, Haoyue Zhang, James Beasley, Patricia McCaw, and Sarah Young. “Quantification of glucosylsphingosine in plasma/serum by UPLC-MS/MS.” In Molecular Genetics and Metabolism, 126:S139–40. Elsevier BV, 2019. https://doi.org/10.1016/j.ymgme.2018.12.359.

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Young, Sarah, Haoyue Zhang, Jian Dai, Patricia McCaw, James Beasley, Denise Peterson, Ashlee Stiles, Marie McDonald, Dwight Koeberl, and Deeksha Bali. “Plasma lyso-Gb3 as a diagnostic marker for Fabry disease.” In Molecular Genetics and Metabolism, 123:S151–S151. Elsevier BV, 2018. https://doi.org/10.1016/j.ymgme.2017.12.421.

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Stiles, Ashlee R., Mariella T. Simon, Alexander Stover, Shaya Eftekharian, Negar Khanlou, Hanlin L. Wang, Shino Magaki, et al. “Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion.” Mol Genet Metab 119, no. 1–2 (September 2016): 91–99. https://doi.org/10.1016/j.ymgme.2016.07.001.

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Stiles, A. R., L. Venturoni, G. Mucci, N. Elbalalesy, M. Woontner, S. Goodman, and J. E. Abdenur. “New cases of DHTKD1 mutations in patients with 2-ketoadipic aciduria.” In JIMD Reports, 25:15–19, 2016. https://doi.org/10.1007/8904_2015_462.

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Stiles, Ashlee R., Sacha Ferdinandusse, Arnaud Besse, Vivek Appadurai, Karen B. Leydiker, E. J. Cambray-Forker, Penelope E. Bonnen, and Jose E. Abdenur. “Successful diagnosis of HIBCH deficiency from exome sequencing and positive retrospective analysis of newborn screening cards in two siblings presenting with Leigh's disease.” Mol Genet Metab 115, no. 4 (August 2015): 161–67. https://doi.org/10.1016/j.ymgme.2015.05.008.

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Stiles, Ashlee R., Julia Kozlitina, Bonne M. Thompson, Jeffrey G. McDonald, Kevin S. King, and David W. Russell. “Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels.” Proc Natl Acad Sci U S A 111, no. 38 (September 23, 2014): E4006–14. https://doi.org/10.1073/pnas.1413561111.

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McDonald, Jeffrey G., Daniel D. Smith, Ashlee R. Stiles, and David W. Russell. “A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma.” J Lipid Res 53, no. 7 (July 2012): 1399–1409. https://doi.org/10.1194/jlr.D022285.

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Stiles, A. R., and D. W. Russell. “SRD5A3: A Surprising Role in Glycosylation.” Cell 142, no. 2 (July 1, 2010): 196–98. https://doi.org/10.1016/j.cell.2010.07.003.

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