Our objective is to have research trials available for a variety of clinical situations, which meet the needs of our patients. We are specifically committed to improve transplant toxicities and patient outcomes. To this end, we consistently open new research trials that are designed to explore new blood and marrow transplant treatment and cellular therapy options and investigate innovative therapies. We have a large team of dedicated research personnel to help accomplish these goals.
Areas of current research include:
- Use of hematopoietic stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML), myelodysplasia, and other non-malignant blood disorders, such as aplastic anemia, sickle cell anemia, thalassemia, hemophagocytic disorders, Wiskott-Aldrich syndrome, aplastic anemia, Diamond-Blackfan anemia, as well as certain inherited metabolic diseases
- Thymus implantation for congenital athymia
- Prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage
- Infusions for children with birth asphyxia, cerebral palsy and autism as well as adults with acute ischemic stroke and osteoarthritis of the knee with autologous and allogeneic cord blood and cord tissue derived allogeneic cells
- DUOC-01 cell therapy for patients with inherited metabolic diseases including leukodystrophies (ALD, MLD, Krabbe, Batten, Neimann-Pick, Sandhoff), mucopolysaccharidoses (Hunter, Sanfilippo) and other rare diseases and in adults with multiple sclerosis
- Genetic analysis of gut microbiome changes during transplant and potential impact on various complications and outcomes
- CD19+ CAR-T cell therapy as first line therapy in HR B-cell ALL (with +MRD at end of consolidation) per COG study CTL019G2201/AALL1721
- Gene therapy for sickle cell disease
- Outcomes of unrelated cord blood transplantation for inherited metabolic diseases (IMD)
- Post-transplant adenovirus infections
- Anti-viral drug development
- Impact of molecular determinants of donor-patient alloreactivity on transplant outcomes
Research Faculty
Andrea L. Bauchat, DO
Areas of interest: hematopoietic transplants for bone marrow failure syndromes, immunodeficiencies/immune dysregulations, and malignancies; survivorship post-HSCT
Timothy A. Driscoll, MD
Areas of interest: CAR-T cell therapy; hematopoietic transplants particularly for neuroblastoma, medulloblastoma and other malignancies; stem cell collection and pheresis.
Joanne Kurtzberg, MD
Areas of interest: Normal and malignant hematopoiesis, regenerative medicine.
Kris M. Mahadeo, MD, MPH
Areas of interest: Congenital Athymia, Complete DiGeorge, Hemoglobinopathies, high-risk hematologic malignancies, CAR-T Cell therapy, minimizing toxicities of therapy, sinusoidal obstructive syndrome, post-transplant lymphoproliferative disease (PTLD).
Paul L. Martin, MD, PhD
Areas of interest: Hematopoietic transplants and CAR-T therapy for leukemia; transplant and gene therapy for sickle cell disease.
Clinical Trials
For further information about clinical trials currently being conducted in the Division of Transplant and Cellular Therapy, please visit DukeHealth.org.