Skip to main content

Research

Overview

The faculty and fellows in the Division of Pediatric Endocrinology have a wide variety of research interests in clinical, translational, and basic investigation related to childhood endocrine disorders. Duke has a strong tradition of interdisciplinary research collaboration; our fellows and faculty currently collaborate with colleagues in the Duke Departments of Medicine, Biomedical Engineering, Pharmacology and Cancer Biology, and Immunology and have appointments in the Duke Molecular Physiology Institute. Pediatric endocrine fellows also have the option to work with faculty at the National Institute of Environmental Health Sciences in Research Triangle Park, NC.

Research Faculty
 

Name
Areas of Special Interest
Michael Freemark, MD, Chief Roles of fetal and placental hormones in the regulation of maternal metabolism and fetal growth; celiac disease in type 1 diabetes; control of food intake and weight gain in Prader Willi syndrome and Down syndrome; metabolomics of malnutrition in children
Deanna Adkins, MD Management of children with gender identity disorders, type 1 diabetes exchange
Pinar Gumus Balikcioglu, MD Metabolomics of obesity, insulin resistance, and type 2 diabetes
Robert Benjamin, MD Type 1 diabetes exchange, mobile teaching applications for graduate and undergraduate medical education
Krystal Irizarry, MD Prader Willi syndrome, control of food intake and weight gain
Nancie MacIver, MD, PhD Role of leptin as a regulator, role of T cell activation and metabolism, mechanism of T cell dysfunction in malnutrition, mechanisms of T cell inflammation in obesity and type 2 diabetes
Natalie Shaw, MD, MMSc Control of gonadotropin secretion during puberty: relationship to sleep

Clinical Research

  • Pathogenesis of insulin resistance and the prevention of type 2 diabetes in high risk children
  • Pathogenesis and treatment of childhood malnutrition in the developing world
  • Pathogenesis of obesity in children with Prader Willi syndrome and Down syndrome
  • Pathogenesis and management of celiac disease in children with type 1 diabetes
  • Control of gonadotropin secretion during puberty
  • Roles of the incretins (ghrelin, GLP-1 and GIP) in the regulation of glucose metabolism and the pathogenesis of type 2 diabetes
  • Role of GH in the regulation of cardiac growth and function in puberty

Basic/Translational Research

  • Hormonal control of maternal metabolism and fetal growth
  • Roles of hormones and nutrition in immune cell development, function, and metabolism
  • Roles of macronutrients and gastrointestinal hormones in the control of appetite and weight gain 

Clinical Trials

For information about clinical trials currently being conducted in Division of Endocrinology, please visit dukechildrens.org.