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Phillip Brian Smith, MD

Samuel L. Katz Professor of Pediatrics
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 800 W. Morgan St Box 17969, DC 756, Durham, NC 27701
Phone: (919) 668-8951
Email address: brian.smith@duke.edu

Dr. Smith completed his residency in pediatrics and a fellowship in neonatal medicine at Duke University Medical Center in 2004 and 2007, respectively. He completed an MHS in clinical research from Duke University in 2006 and an MPH in biostatistics from the University of North Carolina at Chapel Hill in 2009. He research is focused on pediatric drug safety, neonatal pharmacology, and the epidemiology of neonatal infections. He is the chief of the Division of Quantitative Sciences in the Department of Pediatrics at Duke University Medical Center. Dr. Smith is or has been the protocol chair for more than 10 studies of drugs in infants and children. He is the Principal Investigator for the Environmental Influences on Child Health Outcomes (ECHO) Coordinating Center.

Education and Training

  • Fellowship in Neonatal-Perinatal Medicine, Pediatrics, Duke University, 2004 - 2007
  • Pediatric Internship & Residency, Pediatrics, Duke University, 2001 - 2004
  • M.P.H., University of North Carolina at Chapel Hill, 2009
  • M.H.S., Duke University School of Medicine, 2006
  • M.D., Mercer University, 2001

Selected Grants and Awards

Publications

Balevic, Stephen J., P Brian Smith, Daniela Testoni, Huali Wu, Kim L. R. Brouwer, Kanecia O. Zimmerman, Nazario D. Rivera-Chaparro, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Cefazolin pharmacokinetics in premature infants..” J Perinatol 39, no. 9 (September 2019): 1213–18. https://doi.org/10.1038/s41372-019-0368-z.

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Edwards, Laura, C Michael Cotten, P Brian Smith, Ronald Goldberg, Shampa Saha, Abhik Das, Abbot R. Laptook, et al. “Inadequate oral feeding as a barrier to discharge in moderately preterm infants..” J Perinatol 39, no. 9 (September 2019): 1219–28. https://doi.org/10.1038/s41372-019-0422-x.

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Puia-Dumitrescu, Mihai, P Brian Smith, Jian Zhao, Angela Soriano, Elizabeth H. Payne, Barrie Harper, Ellen Bendel-Stenzel, et al. “Dosing and Safety of Off-label Use of Caffeine Citrate in Premature Infants..” J Pediatr 211 (August 2019): 27-32.e1. https://doi.org/10.1016/j.jpeds.2019.04.028.

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Gerhart, Jacqueline G., Kevin M. Watt, Andrea Edginton, Kelly C. Wade, Sara N. Salerno, Daniel K. Benjamin, P Brian Smith, et al. “Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants..” In Cpt Pharmacometrics Syst Pharmacol, 8:500–510, 2019. https://doi.org/10.1002/psp4.12414.

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Greenberg, Rachel G., Dhuly Chowdhury, Nellie I. Hansen, P Brian Smith, Barbara J. Stoll, Pablo J. Sánchez, Abhik Das, et al. “Prolonged duration of early antibiotic therapy in extremely premature infants..” Pediatr Res 85, no. 7 (June 2019): 994–1000. https://doi.org/10.1038/s41390-019-0300-4.

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Smith, P Brian, C Michael Cotten, Mark L. Hudak, Janice E. Sullivan, Brenda B. Poindexter, Michael Cohen-Wolkowiez, Felix Boakye-Agyeman, et al. “Rifampin Pharmacokinetics and Safety in Preterm and Term Infants..” Antimicrob Agents Chemother 63, no. 6 (June 2019). https://doi.org/10.1128/AAC.00284-19.

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Hanvey, I Blaire, Sofia Aliaga, Matthew M. Laughon, Daniela Testoni, P Brian Smith, and Melissa Bauserman. “Trial Characteristics That Affect Parental Consent in Neonatal Drug Trials..” Am J Perinatol 36, no. 7 (June 2019): 759–64. https://doi.org/10.1055/s-0038-1675157.

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Greenberg, Rachel G., Sreepriya Gayam, Destiny Savage, Andrew Tong, Daniel Gorham, Ari Sholomon, Reese H. Clark, et al. “Furosemide Exposure and Prevention of Bronchopulmonary Dysplasia in Premature Infants..” J Pediatr 208 (May 2019): 134-140.e2. https://doi.org/10.1016/j.jpeds.2018.11.043.

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Watt, Kevin M., Christoph P. Hornik, Stephen J. Balevic, Gratias Mundakel, C Michael Cotten, Barrie Harper, Daniel K. Benjamin, et al. “Pharmacokinetics of ticarcillin-clavulanate in premature infants..” Br J Clin Pharmacol 85, no. 5 (May 2019): 1021–27. https://doi.org/10.1111/bcp.13882.

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Taylor, Genevieve, Wesley Jackson, Christoph P. Hornik, Alec Koss, Sreekar Mantena, Kenya Homsley, Blair Gattis, et al. “Surfactant Administration in Preterm Infants: Drug Development Opportunities..” J Pediatr 208 (May 2019): 163–68. https://doi.org/10.1016/j.jpeds.2018.11.041.

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