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Phillip Brian Smith, MD

Samuel L. Katz Distinguished Professor of Pediatrics
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 800 W. Morgan St Box 17969, DC 756, Durham, NC 27701
Phone: (919) 668-8951
Email address: brian.smith@duke.edu

Dr. Smith completed his residency in pediatrics and a fellowship in neonatal medicine at Duke University Medical Center in 2004 and 2007, respectively. He completed an MHS in clinical research from Duke University in 2006 and an MPH in biostatistics from the University of North Carolina at Chapel Hill in 2009. He research is focused on pediatric drug safety, neonatal pharmacology, and the epidemiology of neonatal infections. He is the chief of the Division of Quantitative Sciences in the Department of Pediatrics at Duke University Medical Center. Dr. Smith is or has been the protocol chair for more than 10 studies of drugs in infants and children. He is the Principal Investigator for the Environmental Influences on Child Health Outcomes (ECHO) Coordinating Center.

Education and Training

  • Fellowship in Neonatal-Perinatal Medicine, Pediatrics, Duke University, 2004 - 2007
  • Pediatric Internship & Residency, Pediatrics, Duke University, 2001 - 2004
  • M.P.H., University of North Carolina at Chapel Hill, 2009
  • M.H.S., Duke University School of Medicine, 2006
  • M.D., Mercer University, 2001

Selected Grants and Awards

Publications

Zimmerman, Kanecia O., Huali Wu, Matthew Laughon, Rachel G. Greenberg, Richard Walczak, Scott R. Schulman, P Brian Smith, Christoph P. Hornik, Michael Cohen-Wolkowiez, and Kevin M. Watt. “Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass.” Anesth Analg 129, no. 6 (December 2019): 1519–28. https://doi.org/10.1213/ANE.0000000000003700.

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Puia-Dumitrescu, Mihai, David T. Tanaka, Tracy G. Spears, Cecil J. Daniel, Karan R. Kumar, Kamlesh Athavale, Sandra E. Juul, and P Brian Smith. “Patterns of phlebotomy blood loss and transfusions in extremely low birth weight infants.” J Perinatol 39, no. 12 (December 2019): 1670–75. https://doi.org/10.1038/s41372-019-0515-6.

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Gonzalez, Daniel, Matthew M. Laughon, P Brian Smith, Shufan Ge, Namasivayam Ambalavanan, Andrew Atz, Gregory M. Sokol, et al. “Population pharmacokinetics of sildenafil in extremely premature infants.” Br J Clin Pharmacol 85, no. 12 (December 2019): 2824–37. https://doi.org/10.1111/bcp.14111.

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Ji, Dabin, P Brian Smith, Reese H. Clark, Kanecia O. Zimmerman, Matthew Laughon, Lawrence Ku, and Rachel G. Greenberg. “Wide variation in caffeine discontinuation timing in premature infants.” J Perinatol, November 22, 2019. https://doi.org/10.1038/s41372-019-0561-0.

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Gonski, Samantha, Susan R. Hupp, C Michael Cotten, Reese H. Clark, Matthew Laughon, Kevin Watt, Christoph P. Hornik, Karan Kumar, P Brian Smith, and Rachel G. Greenberg. “Risk of development of treated retinopathy of prematurity in very low birth weight infants.” J Perinatol 39, no. 11 (November 2019): 1562–68. https://doi.org/10.1038/s41372-019-0487-6.

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Greene, Nathaniel H., Rachel G. Greenberg, Sean M. O’Brien, Alex R. Kemper, Marie Lynn Miranda, Reese H. Clark, and P Brian Smith. “Variation in Gastrostomy Tube Placement in Premature Infants in the United States.” Am J Perinatol 36, no. 12 (October 2019): 1243–49. https://doi.org/10.1055/s-0038-1676591.

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Balevic, Stephen J., P Brian Smith, Daniela Testoni, Huali Wu, Kim L. R. Brouwer, Kanecia O. Zimmerman, Nazario D. Rivera-Chaparro, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Cefazolin pharmacokinetics in premature infants.” J Perinatol 39, no. 9 (September 2019): 1213–18. https://doi.org/10.1038/s41372-019-0368-z.

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Edwards, Laura, C Michael Cotten, P Brian Smith, Ronald Goldberg, Shampa Saha, Abhik Das, Abbot R. Laptook, et al. “Inadequate oral feeding as a barrier to discharge in moderately preterm infants.” J Perinatol 39, no. 9 (September 2019): 1219–28. https://doi.org/10.1038/s41372-019-0422-x.

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Puia-Dumitrescu, Mihai, P Brian Smith, Jian Zhao, Angela Soriano, Elizabeth H. Payne, Barrie Harper, Ellen Bendel-Stenzel, et al. “Dosing and Safety of Off-label Use of Caffeine Citrate in Premature Infants.” J Pediatr 211 (August 2019): 27-32.e1. https://doi.org/10.1016/j.jpeds.2019.04.028.

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Gerhart, Jacqueline G., Kevin M. Watt, Andrea Edginton, Kelly C. Wade, Sara N. Salerno, Daniel K. Benjamin, P Brian Smith, et al. “Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants.” In Cpt Pharmacometrics Syst Pharmacol, 8:500–510, 2019. https://doi.org/10.1002/psp4.12414.

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