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Phillip Brian Smith, MD

Samuel L. Katz Distinguished Professor of Pediatrics
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 800 W. Morgan St Box 17969, DC 756, Durham, NC 27701
Phone: (919) 668-8951
Email address: brian.smith@duke.edu

Dr. Smith completed his residency in pediatrics and a fellowship in neonatal medicine at Duke University Medical Center in 2004 and 2007, respectively. He completed an MHS in clinical research from Duke University in 2006 and an MPH in biostatistics from the University of North Carolina at Chapel Hill in 2009. He research is focused on pediatric drug safety, neonatal pharmacology, and the epidemiology of neonatal infections. He is the chief of the Division of Quantitative Sciences in the Department of Pediatrics at Duke University Medical Center. Dr. Smith is or has been the protocol chair for more than 10 studies of drugs in infants and children. He is the Principal Investigator for the Environmental Influences on Child Health Outcomes (ECHO) Coordinating Center.

Education and Training

  • Fellowship in Neonatal-Perinatal Medicine, Pediatrics, Duke University, 2004 - 2007
  • Pediatric Internship & Residency, Pediatrics, Duke University, 2001 - 2004
  • M.P.H., University of North Carolina - Chapel Hill, 2009
  • M.H.S., Duke University School of Medicine, 2006
  • M.D., Mercer University, 2001

Selected Grants and Awards

Publications

Stark, Ashley, Julie Childers, Morgan England, Reese H. Clark, Matthew Laughon, Michael Cohen-Wolkowiez, Daniel K. Benjamin, P Brian Smith, Kelly Wade, and Rachel G. Greenberg. “Dosing of Antimicrobials in the Neonatal Intensive Care Unit: Does Clinical Practice Reflect Pharmacokinetics-based Recommendations?” Pediatr Infect Dis J 39, no. 8 (August 2020): 713–17. https://doi.org/10.1097/INF.0000000000002657.

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Ericson, Jessica E., John McGuire, Marian G. Michaels, Adam Schwarz, Robert Frenck, Jaime G. Deville, Swati Agarwal, et al. “Hospital-acquired Pneumonia and Ventilator-associated Pneumonia in Children: A Prospective Natural History and Case-Control Study.” Pediatr Infect Dis J 39, no. 8 (August 2020): 658–64. https://doi.org/10.1097/INF.0000000000002642.

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Ericson, Jessica E., Christoph P. Hornik, Rachel G. Greenberg, Reese H. Clark, Adriana H. Tremoulet, Jennifer Le, Michael Cohen-Wolkowiez, P Brian Smith, Daniel K. Benjamin, and Daniel K. Best Pharmaceuticals for Children Act – Pediatric Trials Network. “Paradoxical Antibiotic Effect of Ampicillin: Use of a Population Pharmacokinetic Model to Evaluate a Clinical Correlate of the Eagle Effect in Infants With Bacteremia.” Pediatr Infect Dis J 39, no. 8 (August 2020): 725–29. https://doi.org/10.1097/INF.0000000000002663.

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Maharaj, Anil R., Huali Wu, Christoph P. Hornik, Stephen J. Balevic, Chi D. Hornik, P Brian Smith, Daniel Gonzalez, et al. “Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019.” Jama Pediatr, June 5, 2020, e202422. https://doi.org/10.1001/jamapediatrics.2020.2422.

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Commander, Sarah Jane, Jamie Gao, Erin K. Zinkhan, Gloria Heresi, Sherry E. Courtney, Adrian P. Lavery, Paula Delmore, et al. “Safety of Metronidazole in Late Pre-term and Term Infants with Complicated Intra-abdominal Infections.” Pediatr Infect Dis J, May 20, 2020. https://doi.org/10.1097/INF.0000000000002698.

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Puia-Dumitrescu, Mihai, Daniel K. Benjamin, P Brian Smith, Rachel G. Greenberg, Nada Abuzaid, Winsome Andrews, Kris Chellani, et al. “Impact of Gastrostomy Tube Placement on Short-Term Weight Gain in Hospitalized Premature Infants.” Jpen J Parenter Enteral Nutr 44, no. 2 (February 2020): 355–60. https://doi.org/10.1002/jpen.1539.

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Ji, Dabin, P Brian Smith, Reese H. Clark, Kanecia O. Zimmerman, Matthew Laughon, Lawrence Ku, and Rachel G. Greenberg. “Wide variation in caffeine discontinuation timing in premature infants.” J Perinatol 40, no. 2 (February 2020): 288–93. https://doi.org/10.1038/s41372-019-0561-0.

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Dallefeld, S. H., P. B. Smith, E. G. Crenshaw, K. R. Daniel, M. L. Gilleskie, D. S. Smith, S. Balevic, et al. “Comparative safety profile of chloral hydrate versus other sedatives for procedural sedation in hospitalized infants.” J Neonatal Perinatal Med 13, no. 2 (2020): 159–65. https://doi.org/10.3233/NPM-190214.

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Zimmerman, Kanecia O., Huali Wu, Matthew Laughon, Rachel G. Greenberg, Richard Walczak, Scott R. Schulman, P Brian Smith, Christoph P. Hornik, Michael Cohen-Wolkowiez, and Kevin M. Watt. “Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass.” Anesth Analg 129, no. 6 (December 2019): 1519–28. https://doi.org/10.1213/ANE.0000000000003700.

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Puia-Dumitrescu, Mihai, David T. Tanaka, Tracy G. Spears, Cecil J. Daniel, Karan R. Kumar, Kamlesh Athavale, Sandra E. Juul, and P Brian Smith. “Patterns of phlebotomy blood loss and transfusions in extremely low birth weight infants.” J Perinatol 39, no. 12 (December 2019): 1670–75. https://doi.org/10.1038/s41372-019-0515-6.

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