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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Richardson, Paul, Angela Smith, Sally Arai, Stephan A. Grupp, Nancy A. Kernan, Roberta Adams, Paul L. Martin, et al. “Defibrotide (DF) In the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF): Results of a Treatment IND Expanded Access Protocol.” In Blood, 116:399–400. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

Richardson, Paul G., Gideon Steinbach, Nancy Kernan, Eva C. Guinan, Allen R. Chen, Paul L. Martin, Amrita Krishnan, et al. “Meta-Analysis of Defibrotide (DF) In the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF) with Comparison to a Historical Control (HC).” In Blood, 116:1430–31. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

Parikh, Suhag H., Paul L. Martin, Timothy A. Driscoll, Jennifer Baker, Ketti Piersol, Jerelyn Moffet, Andre Stokhuyzen, Joanne Kurtzberg, and Paul Szabolcs. “Reduced Intensity Conditioning In Children Undergoing Unrelated Umbilical Cord Blood Transplantation for Non-Malignant Diseases: Preliminary Results Demonstrate a High Rate of Engraftment and Low Incidence of Gvhd..” In Blood, 116:1453–54. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

Maloney, Kelly W., William L. Carroll, Andrew J. Carroll, Meenakshi Devidas, Michael J. Borowitz, Paul L. Martin, Jeanette Pullen, et al. “Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: a report from the Children's Oncology Group..” Blood 116, no. 7 (August 19, 2010): 1045–50. https://doi.org/10.1182/blood-2009-07-235291.

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Richardson, Paul G., Robert J. Soiffer, Joseph H. Antin, Hajime Uno, Zhezhen Jin, Joanne Kurtzberg, Paul L. Martin, et al. “Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial..” Biol Blood Marrow Transplant 16, no. 7 (July 2010): 1005–17. https://doi.org/10.1016/j.bbmt.2010.02.009.

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Coppell, Jason A., Paul G. Richardson, Robert Soiffer, Paul L. Martin, Nancy A. Kernan, Allen Chen, Eva Guinan, et al. “Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome..” Biol Blood Marrow Transplant 16, no. 2 (February 2010): 157–68. https://doi.org/10.1016/j.bbmt.2009.08.024.

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Richardson, Paul, Marcie Tomblyn, Nancy Kernan, Joel A. Brochstein, Shin Mineishi, Amanda Termuhlen, Sally Arai, et al. “Defibrotide (DF) in the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF) Following Stem Cell Transplantation (SCT): Results of a Phase 3 Study Utilizing a Historical Control.” In Blood, 114:272–73. AMER SOC HEMATOLOGY, 2009.

Scholars@Duke

Tewari, Priti, Susan Wood, Paul L. Martin, Suhag H. Parikh, Paul Szabolcs, Kristin M. Page, Timothy Driscoll, Joanne Kurtzberg, and Vinod K. Prasad. “Transplantation Following Myeloablative Cytoreduction Results in Excellent Survival, Long-Term Engraftment, and Donor Chimerism in Children with Chronic Granulomatous Disease Across Donor and Graft Sources.” In Blood, 114:1319–1319. AMER SOC HEMATOLOGY, 2009.

Scholars@Duke

Parikh, Suhag H., Adam Mendizabal, Paul L. Martin, Vinod K. Prasad, Paul Szabolcs, Timothy A. Driscoll, and Joanne Kurtzberg. “Unrelated donor umbilical cord blood transplantation in pediatric myelodysplastic syndrome: a single-center experience..” Biol Blood Marrow Transplant 15, no. 8 (August 2009): 948–55. https://doi.org/10.1016/j.bbmt.2009.04.010.

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Cash, J. V., C. M. Sweezy, A. Browne-Topete, P. L. Martin, D. L. Georgas, and N. A. Larrier. “Easing the TBI Experience in the Pre-School Patient.” Biology of Blood and Marrow Transplantation 15, no. 2 (February 2009): 32–33. https://doi.org/10.1016/j.bbmt.2008.12.100.

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