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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.  

For most of my time at Duke I have concentrated on providing high quality care for high risk leukemia patients who require high intensity therapies, such as stem cell transplant and immunotherapy.  As a member of the Pediatric Transplant and Cellular Therapy Division I provide clinical care for these patients.  As a member of various cooperative groups and local PI for several drug trials, I have worked to provide better care and more specific therapies for the toxicities associated with stem cell transplant.  

I have also collaborated with the Pediatric Immunology Division to provide a life-saving therapy for a small group of patients with thymic dysfunction, which causes severe immunodeficiency.  Our clinical team now provides support during these patients hospital admissions for donor thymus tissue implantation.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Yang, Jun J., Cheng Cheng, Meenakshi Devidas, Xueyuan Cao, Yiping Fan, Dario Campana, Wenjian Yang, et al. “Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.” Nat Genet 43, no. 3 (March 2011): 237–41. https://doi.org/10.1038/ng.763.

Full Text

Parikh, S. H., P. L. Martin, T. A. Driscoll, J. Baker, K. Piersol, J. Moffet, A. Stokhuyzen, J. Cash, J. Kurtzberg, and P. Szabolcs. “A Prospective Study of Reduced Intensity Conditioning (RIC) in Children Undergoing Unrelated Umbilical Cord Blood Transplantation (UCBT) for Non-Malignant Diseases: Preliminary Results Demonstrate a High Rate of Engraftment and Low Incidence of GVHD.” In Biology of Blood and Marrow Transplantation, 17:S265–66. Elsevier BV, 2011. https://doi.org/10.1016/j.bbmt.2010.12.338.

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Edmisten, J. H., J. Prewitt, P. L. Martin, and K. Little. “Caregivers Helping in Relieving Pain – C.H.I.R.P. Project.” In Biology of Blood and Marrow Transplantation, 17:S361–S361. Elsevier BV, 2011. https://doi.org/10.1016/j.bbmt.2010.12.621.

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Prasad, V. K., A. Mendizabal, P. Tewari, K. Page, S. H. Parikh, P. Szabolcs, T. A. Driscoll, P. L. Martin, and J. Kurtzberg. “Differential Impact of HLA-A, -B, and -DRB1 Mismatching in Relation to Other Variables on the Outcomes of Myeloablative Unrelated Single Donor Umbilical Cord Blood Transplantation From 4/6 Matched Units in Children and Young Adults.” In Biology of Blood and Marrow Transplantation, 17:S185–86. Elsevier BV, 2011. https://doi.org/10.1016/j.bbmt.2010.12.100.

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Mahadeo, K. M., S. H. Parikh, T. A. Driscoll, K. Page, P. Szabolcs, P. L. Martin, J. Kurtzberg, and V. K. Prasad. “Durable Engraftment and Correction of Genetic Defect in Children with Congenital Amegakaryocytic Thrombocytopenia Following Myeloablative Umbilical Cord Blood Transplantation.” In Biology of Blood and Marrow Transplantation, 17:S256–S256. Elsevier BV, 2011. https://doi.org/10.1016/j.bbmt.2010.12.312.

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Bain, M. E., P. L. Martin, S. Kojis, S. B. Trout, and J. Kurtzberg. “Meeting the Challenge: Developing a Model to Care for an Adolescent Patient With Leukemia and Severe Autism.” In Biology of Blood and Marrow Transplantation, 17:S283–S283. Elsevier BV, 2011. https://doi.org/10.1016/j.bbmt.2010.12.391.

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Yang, Jun, Heng Xu, Cheng Cheng, Meenakshi Devidas, Deqing Pei, Yiping Fan, Wenjian Yang, et al. “ARID5B Genetic Polymorphisms Contribute to Racial Disparities In Childhood Acute Lymphoblastic Leukemia: A Children's Oncology Group Study.” In Blood, 116:9–10. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

Richardson, Paul, Angela Smith, Sally Arai, Stephan A. Grupp, Nancy A. Kernan, Roberta Adams, Paul L. Martin, et al. “Defibrotide (DF) In the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF): Results of a Treatment IND Expanded Access Protocol.” In Blood, 116:399–400. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

Richardson, Paul G., Gideon Steinbach, Nancy Kernan, Eva C. Guinan, Allen R. Chen, Paul L. Martin, Amrita Krishnan, et al. “Meta-Analysis of Defibrotide (DF) In the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF) with Comparison to a Historical Control (HC).” In Blood, 116:1430–31. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

Parikh, Suhag H., Paul L. Martin, Timothy A. Driscoll, Jennifer Baker, Ketti Piersol, Jerelyn Moffet, Andre Stokhuyzen, Joanne Kurtzberg, and Paul Szabolcs. “Reduced Intensity Conditioning In Children Undergoing Unrelated Umbilical Cord Blood Transplantation for Non-Malignant Diseases: Preliminary Results Demonstrate a High Rate of Engraftment and Low Incidence of Gvhd.” In Blood, 116:1453–54. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

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