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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.  

For most of my time at Duke I have concentrated on providing high quality care for high risk leukemia patients who require high intensity therapies, such as stem cell transplant and immunotherapy.  As a member of the Pediatric Transplant and Cellular Therapy Division I provide clinical care for these patients.  As a member of various cooperative groups and local PI for several drug trials, I have worked to provide better care and more specific therapies for the toxicities associated with stem cell transplant.  

I have also collaborated with the Pediatric Immunology Division to provide a life-saving therapy for a small group of patients with thymic dysfunction, which causes severe immunodeficiency.  Our clinical team now provides support during these patients hospital admissions for donor thymus tissue implantation.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Richardson, P. G., R. J. Soiffer, J. H. Antin, Z. Jin, J. Kurtzberg, P. L. Martin, D. Hockenbery, et al. “Defibrotide (DF) for the treatment of Veno-Occlusive Disease (VOD) and multi-system organ failure (MOF) post SCT: Analysis of response and survival according to degree and type of MOV.” In Blood, 106:120A-120A. AMER SOC HEMATOLOGY, 2005.

Scholars@Duke

Borowitz, Michael J., D Jeanette Pullen, Naomi Winick, Paul L. Martin, W Paul Bowman, and Bruce Camitta. “Comparison of diagnostic and relapse flow cytometry phenotypes in childhood acute lymphoblastic leukemia: implications for residual disease detection: a report from the children's oncology group.” Cytometry B Clin Cytom 68, no. 1 (November 2005): 18–24. https://doi.org/10.1002/cyto.b.20071.

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Kokoszka, A. K., M. A. Frey, G. Talbert, and P. L. Martin. “Infection in the pediatric patient after bone marrow or stem cell transplantation: Nursing considerations.” In Biology of Blood and Marrow Transplantation, 11:100–100. Elsevier BV, 2005. https://doi.org/10.1016/j.bbmt.2004.12.297.

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Stanton, T. J., P. L. Martin, and G. Talbert. “Management of cytomegalovirus in the pediatric bone marrow/stem cell transplantation population.” In Biology of Blood and Marrow Transplantation, 11:104–104. Elsevier BV, 2005. https://doi.org/10.1016/j.bbmt.2004.12.314.

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Parikh, S. H., P. L. Martin, P. Szabolcs, S. Ann, V. Prasad, T. Driscoll, and J. Kurtzberg. “Outcomes of unrelated umbilical cord blood transplantation in pediatric patients with myelodysplastic syndrome.” In Biology of Blood and Marrow Transplantation, 11:80–80. Elsevier BV, 2005. https://doi.org/10.1016/j.bbmt.2004.12.236.

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Kurtzberg, J., P. Szabolcs, S. Wood, G. Ciocci, T. Driscoll, V. Prasad, S. Parikh, P. L. Martin, J. Allison, and M. L. Escolar. “Treatment of pediatric patients with Sanfilippo syndrome (MPS IIIA and IIIB) with unrelated umbilical cord blood transplantation.” In Biology of Blood and Marrow Transplantation, 11:83–84. Elsevier BV, 2005. https://doi.org/10.1016/j.bbmt.2004.12.246.

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Borowitz, Michael J., D Jeanette Pullen, Naomi Winick, P. L. Martin, W Paul Bowman, and Bruce Camitta. “Comparison of Diagnostic and Relapse Flow Cytometry Phenotypes in Childhood ALL: Implications for Residual Disease (MRD) Detection.” In Blood, 104:1091–1091. American Society of Hematology, 2004. https://doi.org/10.1182/blood.v104.11.1091.1091.

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Richardson, Paul G., R. J. Soiffer, J. H. Antin, S. D. Voss, Z. Jin, J. Kurtzberg, P. L. Martin, et al. “Defibrotide (DF) for the Treatment of Severe Veno-Occlusive Disease (VOD) and Multi-System Organ Failure (MOF) Post SCT: Final Results of a Phase II, Multicenter, Randomized Study and Preliminary Analyses of Surrogate Markers and Ultrasound Findings.” In Blood, 104:350–350. American Society of Hematology, 2004. https://doi.org/10.1182/blood.v104.11.350.350.

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Davies, S. M., M. Borowitz, M. Devidas, N. Winick, P. L. Martin, P. Bowman, J. Elliott, S. Linda, E. H. Cook, and M. V. Relling. “Pharmacogenetics of minimal residual disease response in children with acute lymphoblastic leukemia (ALL).” In Blood, 104:132A-132A. AMER SOC HEMATOLOGY, 2004.

Scholars@Duke

Quaranta, Brian P., Edward C. Halperin, Joanne Kurtzberg, Robert Clough, and Paul L. Martin. “The incidence of testicular recurrence in boys with acute leukemia treated with total body and testicular irradiation and stem cell transplantation.” Cancer 101, no. 4 (August 15, 2004): 845–50. https://doi.org/10.1002/cncr.20413.

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