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Paul Langlie Martin, MD, PhD

Professor of Pediatrics
Chief, Division of Pediatric Blood and Marrow Transplantation
Member of the Duke Cancer Institute
Campus mail: 1400 Morrene Rd, Durham, NC 27705
Phone: (919) 668-1124
Email address: paul.martin@duke.edu

For most of my career in Pediatric Hematology/Oncology I have focused on the use of stem cell transplant for the treatment of pediatric leukemias (ALL, AML, CML and JMML) and other non-malignant blood disorders, such as thalassemia, hemaphagocytic disorders, Wiskott-Aldrich, aplastic anemia, Diamond-Blackfan Anemia, as well as inherited metabolic diseases. In addition to focusing on determining the best use of stem cell transplants for these disorders, I have also been involved in clinical research investigating the prevention and treatment of transplant related morbidity, particularly veno-occlusive disease of the liver, infections and diffuse alveolar hemorrhage. As study chair for the Children's Oncology Group protocol 9904, I was involved in the development, implementation and analysis of a large, international frontline study of childhood acute lymphoblastic leukemia. Results from this study show that a significant number of children with certain favorable cytogenetic abnormalities in their leukemic cells and who have a rapid response to their initial chemotherapy can expect to have a >95% chance of cure when treated with relatively low intensity chemotherapy.  

For most of my time at Duke I have concentrated on providing high quality care for high risk leukemia patients who require high intensity therapies, such as stem cell transplant and immunotherapy.  As a member of the Pediatric Transplant and Cellular Therapy Division I provide clinical care for these patients.  As a member of various cooperative groups and local PI for several drug trials, I have worked to provide better care and more specific therapies for the toxicities associated with stem cell transplant.  

I have also collaborated with the Pediatric Immunology Division to provide a life-saving therapy for a small group of patients with thymic dysfunction, which causes severe immunodeficiency.  Our clinical team now provides support during these patients hospital admissions for donor thymus tissue implantation.

Education and Training

  • Fellow, Pediatric Hematology/Oncology, Pediatrics, Yale University, 1989 - 1992
  • Resident, Pediatrics, Yale University, 1988 - 1989
  • Intern, Pediatrics, Yale University, 1987 - 1988
  • Ph.D., Washington University in St. Louis, 1987
  • M.D., Washington University in St. Louis, 1987

Publications

Maloney, K., W. L. Carroll, A. Carroll, M. Devidas, S. P. Hunger, P. L. Martin, C. L. Willman, N. Winick, J. Whitlock, and B. M. Camitta. “Comparison of the biology of Down syndrome (DS) acute lymphoblastic leukemia (ALL) and non-DS ALL: Children’s Oncology Group (COG) study P9900.” Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 10003–10003. https://doi.org/10.1200/jco.2008.26.15_suppl.10003.

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Davies, Stella M., Michael J. Borowitz, Gary L. Rosner, Kristin Ritz, Meenakshi Devidas, Naomi Winick, Paul L. Martin, et al. “Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group.” Blood 111, no. 6 (March 15, 2008): 2984–90. https://doi.org/10.1182/blood-2007-09-114082.

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White, Matthew S., Paul L. Martin, and Thomas W. McLean. “Acute myelogenous leukemia associated with Ollier disease.” Pediatr Blood Cancer 50, no. 3 (March 2008): 645–46. https://doi.org/10.1002/pbc.21050.

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Coppell, J. A., P. G. Richardson, P. L. Martin, M. Iacobelli, E. Carreras, T. Ruutu, T. Barbui, R. Soiffer, and D. Niederwieser. “Incidence of hepatic veno-occlusive disease following stem cell transplantation: systematic review of literature from 1979-2007.” In Bone Marrow Transplantation, 41:S91–S91. NATURE PUBLISHING GROUP, 2008.

Scholars@Duke

Mohamed, A., D. Niedzwiecki, J. H. Baker, R. Vinesett, P. L. Martin, T. A. Driscoll, V. K. Prasad, S. Parikh, J. Kurtzberg, and P. Szabolcs. “208: The Use, Safety, and Efficacy of Daclizumab for Steroid Refractory Graft-Versus-Host-Disease (GVHD) after Unrelated Cord Blood Transplantation (UCBT).” In Biology of Blood and Marrow Transplantation, 14:77–77. Elsevier BV, 2008. https://doi.org/10.1016/j.bbmt.2007.12.217.

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Parikh, S. H., A. Mendizabal, P. L. Martin, P. Szabolcs, V. K. Prasad, T. A. Driscoll, and J. Kurtzberg. “224: Outcomes of Unrelated Umbilical Cord Blood Transplantation in Pediatric Patients with Myelodysplastic Syndrome.” In Biology of Blood and Marrow Transplantation, 14:83–84. Elsevier BV, 2008. https://doi.org/10.1016/j.bbmt.2007.12.233.

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Prasad, V. K., A. Mendizabal, S. H. Parikh, P. Szabolcs, T. Driscoll, K. Page, S. Lakshinarayanan, et al. “63: Outcomes of Unrelated Umbilical Cord Blood Transplantation in 159 Young Patients with Peroxisomal and Lysosomal Storage Disorders at a Single Center.” In Biology of Blood and Marrow Transplantation, 14:26–26. Elsevier BV, 2008. https://doi.org/10.1016/j.bbmt.2007.12.071.

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Kelly, Staba S., A. Shahlaee, P. Szabolcs, T. Driscoll, D. Eslin, J. Kurtzberg, and P. L. Martin. “UNRELATED DONOR UMBILICAL CORD BLOOD TRANSPLANT FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (HLH).” In Biology of Blood and Marrow Transplantation, 14:75–75. ELSEVIER SCIENCE INC, 2008.

Scholars@Duke

Parikh, Suhag H., Paul Szabolcs, Vinod K. Prasad, Sonali Lakshminarayanan, Paul L. Martin, Timothy A. Driscoll, and Joanne Kurtzberg. “Correction of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation.” Pediatr Blood Cancer 49, no. 7 (December 2007): 982–84. https://doi.org/10.1002/pbc.21365.

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Prasad, Vinod K., Adam Medizabal, Suhag H. Parikh, Paul Szabolcs, Timothy A. Driscoll, Kristin Page, Sonali Lakshminarayanan, et al. “Analysis of the Cellular Components of the Graft and Clinical Characteristics of 159 Children with Lysosomal and Peroxisomal Disorders (LSD) Undergoing Unrelated Umbilical Cord Blood Transplantation at a Single Center.” In Blood, 110:336–336. American Society of Hematology, 2007. https://doi.org/10.1182/blood.v110.11.336.336.

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