Skip to main content

Mohamad Abdul Mikati, MD

Wilburt C. Davison Distinguished Professor
Professor of Pediatrics
Chief, Division of Pediatric Neurology
Professor of Neurobiology
Faculty Network Member of the Duke Institute for Brain Sciences
Associate of the Duke Initiative for Science & Society
Affiliate of the Center for Brain Imaging and Analysis
Campus mail: Box 3936 Med Ctr, Durham, NC 27710
Phone: (919) 668-0477
Email address: mohamad.mikati@duke.edu

Mohamad A.  Mikati M.D., is the Wilburt C. Davison Professor of Pediatrics, Professor of Neurobiology, and Chief of the Division of Pediatric Neurology. Dr. Mikati’s clinical research has centered on characterization and therapy of pediatric epilepsy and neurology syndromes, describing several new pediatric neurological entities with two carrying his name (POSSUM syndromes # 3708 and 4468), developing novel therapeutic strategies for epilepsy and related disorders particularly Alternating Hemiplegia of Childhood, and applying cutting edge genetic and Magnetic Resonance Imaging techniques to drug resistant pediatric epilepsy.  In the laboratory he has elucidated mechanisms of seizure related neuronal injury, particularly those related to the ceramide pathway, and demonstrated neuroprotective effects of several agents including erythropoietin. Most recently he has concentrated his laboratory research on the pathophysiology of ATP1A3 dysfunction in the brain as model for epilepsy and of Alternating Hemiplegia of Childhood. He has more than 210 peer reviewed publications, 300 abstracts 40 chapters one book and two booklets. He also has more than 5,590 citations in the literature with an h-index of 44 and an i-10index of 118. Dr. Mikati has written chapters on epilepsy and related disorders in the major textbooks of Pediatrics and Pediatric Neurology including Swaiman’s Pediatric Neurology and Nelson’s Pediatrics. Before joining Duke in 2008 he had completed his M.D. and Pediatric training at the American University of Beirut, his Neurology at the Massachusetts General Hospital, his Neurophysiology at Boston Children’s Hospital and had been on the Faculty at Harvard as Director of Research in the Epilepsy Program at Boston Children’s Hospital and then as Professor and Chairman, Department of Pediatrics, Founder and Director of the Adult and Pediatric Epilepsy Program at the American University of Beirut. Dr. Mikati has had several international leadership roles including being President of the Union of the Middle Eastern and Mediterranean Pediatric Societies, on the Standing Committee of the International Pediatric Association, Officer of the International Child Neurology Association, Consultant to UNICEF, WHO, and the American Board of Pediatrics, and being one of only two Pediatric Neurologists, initially chosen worldwide, on the WHO advisory committee for the International Classification of Disease. He has received several national and international honors including, among others, Merritt Putnam American Epilepsy Society Fellowship Award, Harvard Community Health Plan Peer recognition Award, Debs Research Award, Hamdan Award for contributions to Medicine, Hans Zellweger Award for contributions to Pediatric Neurology, Patient Choice Award and the Michael Frank Award for research and lifetime contributions to the field of Pediatric Neurology.

Education and Training

  • Fellow in Neurology, Pediatrics, Harvard University , 1985 - 1987
  • Resident in Pediatric Neurology, Pediatrics, Harvard University , 1982 - 1985
  • Internship & Residency in Pediatrics, Pediatrics, American University of Beirut (Lebanon), 1979 - 1982
  • M.D., American University of Beirut (Lebanon), 1980

Publications

Zhang, Guohui, Rebecca A. Gibson, Marie McDonald, Pengfei Liang, Po Wei Kang, Jingyi Shi, Huanghe Yang, Jianmin Cui, and Mohamad A. Mikati. “A Gain-of-Function Mutation in KCNMA1 Causes Dystonia Spells Controlled With Stimulant Therapy.” Mov Disord, July 7, 2020. https://doi.org/10.1002/mds.28138.

Full Text

Perucca, Piero, Alison Anderson, Dana Jazayeri, Alison Hitchcock, Janet Graham, Marian Todaro, Torbjörn Tomson, et al. “Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load.” Ann Neurol 87, no. 6 (June 2020): 897–906. https://doi.org/10.1002/ana.25724.

Full Text

Ghusayni, Ryan, Jordan P. Richardson, Julie Uchitel, Elie Abdelnour, Melissa McLean, Lyndsey Prange, Tavis Abrahamsen, Allen Song, Jeffrey R. Petrella, and Mohamad A. Mikati. “Magnetic resonance imaging volumetric analysis in patients with Alternating hemiplegia of childhood: A pilot study.” Eur J Paediatr Neurol 26 (May 2020): 15–19. https://doi.org/10.1016/j.ejpn.2020.02.001.

Full Text

Uchitel, Julie, Boris Kantor, Edward C. Smith, and Mohamad A. Mikati. “Viral-Mediated Gene Replacement Therapy in the Developing Central Nervous System: Current Status and Future Directions.” Pediatr Neurol, April 24, 2020. https://doi.org/10.1016/j.pediatrneurol.2020.04.010.

Full Text

Tran, Linh, Jason Richards, Marie McDonald, Allyn McConkie-Rosell, Nicholas Stong, Joan Jasien, Vandana Shashi, and Mohamad A. Mikati. “Epileptic encephalopathy with features of rapid-onset dystonia Parkinsonism and alternating hemiplegia of childhood: a novel combination phenotype associated with ATP1A3 mutation.” Epileptic Disord 22, no. 1 (February 1, 2020): 103–9. https://doi.org/10.1684/epd.2020.1127.

Full Text

Bend, Renee, Lior Cohen, Melissa T. Carter, Michael J. Lyons, Dmitriy Niyazov, Mohamad A. Mikati, Samantha K. Rojas, et al. “Phenotype and mutation expansion of the PTPN23 associated disorder characterized by neurodevelopmental delay and structural brain abnormalities.” Eur J Hum Genet 28, no. 1 (January 2020): 76–87. https://doi.org/10.1038/s41431-019-0487-1.

Full Text

Uchitel, Julie, Errol Alden, Zulfiqar A. Bhutta, Jeffrey Goldhagen, Aditee Pradhan Narayan, Shanti Raman, Nick Spencer, et al. “The Rights of Children for Optimal Development and Nurturing Care.” Pediatrics 144, no. 6 (December 2019). https://doi.org/10.1542/peds.2019-0487.

Full Text

Uchitel, Julie, Ashley Helseth, Lyndsey Prange, Melissa McLean, Ryan Ghusayni, Monisha Sachdev, Arsen Hunanyan, and Mohamad A. Mikati. “The epileptology of alternating hemiplegia of childhood.” Neurology 93, no. 13 (September 24, 2019): e1248–59. https://doi.org/10.1212/WNL.0000000000008159.

Full Text

Sansevere, Arnold J., Ravindra Arya, Iván Sánchez Fernández, William D. Gaillard, Robert C. Tasker, Yi-Chen Lai, Anne E. Anderson, et al. “Electroencephalographic Reporting for Refractory Status Epilepticus.” J Clin Neurophysiol 36, no. 5 (September 2019): 365–70. https://doi.org/10.1097/WNP.0000000000000595.

Full Text

Mesraoua, Boulenouar, Dirk Deleu, Dimitri M. Kullmann, Ashok K. Shetty, Paul Boon, Emilio Perucca, Mohamad A. Mikati, and Ali A. Asadi-Pooya. “Novel therapies for epilepsy in the pipeline.” Epilepsy Behav 97 (August 2019): 282–90. https://doi.org/10.1016/j.yebeh.2019.04.042.

Full Text

Pages