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Mohamad Abdul Mikati, MD

Wilburt C. Davison Distinguished Professor
Professor of Pediatrics
Chief, Division of Pediatric Neurology
Professor of Neurobiology
Faculty Network Member of the Duke Institute for Brain Sciences
Associate of the Duke Initiative for Science & Society
Affiliate of the Center for Brain Imaging and Analysis
Campus mail: Box 3936 Med Ctr, Durham, NC 27710
Phone: (919) 668-0477
Email address: mohamad.mikati@duke.edu

Mohamad A.  Mikati M.D., is the Wilburt C. Davison Professor of Pediatrics, Professor of Neurobiology, and Chief of the Division of Pediatric Neurology. Dr. Mikati’s clinical research has centered on characterization and therapy of pediatric epilepsy and neurology syndromes, describing several new pediatric neurological entities with two carrying his name (POSSUM syndromes # 3708 and 4468), developing novel therapeutic strategies for epilepsy and related disorders particularly Alternating Hemiplegia of Childhood, and applying cutting edge genetic and Magnetic Resonance Imaging techniques to drug resistant pediatric epilepsy.  In the laboratory he has elucidated mechanisms of seizure related neuronal injury, particularly those related to the ceramide pathway, and demonstrated neuroprotective effects of several agents including erythropoietin. Most recently he has concentrated his laboratory research on the pathophysiology of ATP1A3 dysfunction in the brain as model for epilepsy and of Alternating Hemiplegia of Childhood. He has more than 210 peer reviewed publications, 300 abstracts 40 chapters one book and two booklets. He also has more than 5,590 citations in the literature with an h-index of 44 and an i-10index of 118. Dr. Mikati has written chapters on epilepsy and related disorders in the major textbooks of Pediatrics and Pediatric Neurology including Swaiman’s Pediatric Neurology and Nelson’s Pediatrics. Before joining Duke in 2008 he had completed his M.D. and Pediatric training at the American University of Beirut, his Neurology at the Massachusetts General Hospital, his Neurophysiology at Boston Children’s Hospital and had been on the Faculty at Harvard as Director of Research in the Epilepsy Program at Boston Children’s Hospital and then as Professor and Chairman, Department of Pediatrics, Founder and Director of the Adult and Pediatric Epilepsy Program at the American University of Beirut. Dr. Mikati has had several international leadership roles including being President of the Union of the Middle Eastern and Mediterranean Pediatric Societies, on the Standing Committee of the International Pediatric Association, Officer of the International Child Neurology Association, Consultant to UNICEF, WHO, and the American Board of Pediatrics, and being one of only two Pediatric Neurologists, initially chosen worldwide, on the WHO advisory committee for the International Classification of Disease. He has received several national and international honors including, among others, Merritt Putnam American Epilepsy Society Fellowship Award, Harvard Community Health Plan Peer recognition Award, Debs Research Award, Hamdan Award for contributions to Medicine, Hans Zellweger Award for contributions to Pediatric Neurology, Patient Choice Award and the Michael Frank Award for research and lifetime contributions to the field of Pediatric Neurology.

Education and Training

  • Fellow in Neurology, Pediatrics, Harvard University , 1985 - 1987
  • Resident in Pediatric Neurology, Pediatrics, Harvard University , 1982 - 1985
  • Internship & Residency in Pediatrics, Pediatrics, American University of Beirut (Lebanon), 1979 - 1982
  • M.D., American University of Beirut (Lebanon), 1980

Publications

Tran, Linh, and Mohamad A. Mikati. “Therapy of Lennox-Gastaut syndrome.” Epilepsy Behav, December 22, 2020, 107665. https://doi.org/10.1016/j.yebeh.2020.107665.

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Klöckner, Chiara, Heinrich Sticht, Pia Zacher, Bernt Popp, Holly E. Babcock, Dewi P. Bakker, Katy Barwick, et al. “De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy.” In Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2020. https://doi.org/10.1038/s41436-020-01020-w.

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Balestrini, Simona, Mohamad A. Mikati, Reyes Álvarez-García-Rovés, Michael Carboni, Arsen S. Hunanyan, Bassil Kherallah, Melissa McLean, et al. “Cardiac phenotype in ATP1A3-related syndromes: A multicenter cohort study.” Neurology 95, no. 21 (November 24, 2020): e2866–79. https://doi.org/10.1212/WNL.0000000000010794.

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Jasien, Joan Mary, Mohamad A. Mikati, Michaela Kolarova, Brian Smith, Stephanie Thera, and Pierre Lee. “Cognitive and motor function in adults with spina bifida myelomeningocele: a pilot study.” Childs Nerv Syst, November 13, 2020. https://doi.org/10.1007/s00381-020-04964-1.

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Vasquez, Alejandra, Marina Gaínza-Lein, Nicholas S. Abend, Marta Amengual-Gual, Anne Anderson, Ravindra Arya, J Nicholas Brenton, et al. “First-line medication dosing in pediatric refractory status epilepticus.” Neurology 95, no. 19 (November 10, 2020): e2683–96. https://doi.org/10.1212/WNL.0000000000010828.

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Wallace, Keri, Julie Uchitel, Lyndsey Prange, Joan Jasien, Melanie Bonner, Richard D’Alli, Gary Maslow, and Mohamad A. Mikati. “Characterization of Severe and Extreme Behavioral Problems in Patients With Alternating Hemiplegia of Childhood.” Pediatr Neurol 111 (October 2020): 5–12. https://doi.org/10.1016/j.pediatrneurol.2020.06.012.

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Prange, Lyndsey, Milton Pratt, Kristin Herman, Raphael Schiffmann, David M. Mueller, Melissa McLean, Mary Moya Mendez, et al. “D-DEMØ, a distinct phenotype caused by ATP1A3 mutations.” Neurol Genet 6, no. 5 (October 2020): e466. https://doi.org/10.1212/NXG.0000000000000466.

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Pratt, Milton, Julie Uchitel, Nancy McGreal, Kelly Gordon, Lyndsey Prange, Melissa McLean, Richard J. Noel, Blaire Rikard, Mary K. Rogers Boruta, and Mohamad A. Mikati. “Alternating Hemiplegia of Childhood: gastrointestinal manifestations and correlation with neurological impairments.” Orphanet J Rare Dis 15, no. 1 (September 3, 2020): 231. https://doi.org/10.1186/s13023-020-01474-w.

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Sánchez Fernández, Iván, Nicholas S. Abend, Marta Amengual-Gual, Anne Anderson, Ravindra Arya, Cristina Barcia Aguilar, James Nicholas Brenton, et al. “Association of guideline publication and delays to treatment in pediatric status epilepticus.” Neurology 95, no. 9 (September 1, 2020): e1222–35. https://doi.org/10.1212/WNL.0000000000010174.

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Uchitel, Julie, Boris Kantor, Edward C. Smith, and Mohamad A. Mikati. “Viral-Mediated Gene Replacement Therapy in the Developing Central Nervous System: Current Status and Future Directions.” Pediatr Neurol 110 (September 2020): 5–19. https://doi.org/10.1016/j.pediatrneurol.2020.04.010.

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