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Mohamad Abdul Mikati, MD

Wilburt C. Davison Distinguished Professor of Pediatrics, in the School of Medicine
Professor of Pediatrics
Chief, Division of Pediatric Neurology
Professor of Neurobiology
Faculty Network Member of the Duke Institute for Brain Sciences
Associate of the Duke Initiative for Science & Society
Affiliate of the Center for Brain Imaging and Analysis
Campus mail: Box 3936 Med Ctr, Durham, NC 27710
Phone: (919) 668-0477
Email address: mohamad.mikati@duke.edu

Mohamad A.  Mikati M.D., is the Wilburt C. Davison Professor of Pediatrics, Professor of Neurobiology, and Chief of the Division of Pediatric Neurology. Dr. Mikati’s clinical research has centered on characterization and therapy of pediatric epilepsy and neurology syndromes, describing several new pediatric neurological entities with two carrying his name (POSSUM syndromes # 3708 and 4468), developing novel therapeutic strategies for epilepsy and related disorders particularly Alternating Hemiplegia of Childhood, and applying cutting edge genetic and Magnetic Resonance Imaging techniques to drug resistant pediatric epilepsy.  In the laboratory he has elucidated mechanisms of seizure related neuronal injury, particularly those related to the ceramide pathway, and demonstrated neuroprotective effects of several agents including erythropoietin. Most recently he has concentrated his laboratory research on the pathophysiology of ATP1A3 dysfunction in the brain as model for epilepsy and of Alternating Hemiplegia of Childhood. He has more than 210 peer reviewed publications, 300 abstracts 40 chapters one book and two booklets. He also has more than 5,590 citations in the literature with an h-index of 44 and an i-10index of 118. Dr. Mikati has written chapters on epilepsy and related disorders in the major textbooks of Pediatrics and Pediatric Neurology including Swaiman’s Pediatric Neurology and Nelson’s Pediatrics. Before joining Duke in 2008 he had completed his M.D. and Pediatric training at the American University of Beirut, his Neurology at the Massachusetts General Hospital, his Neurophysiology at Boston Children’s Hospital and had been on the Faculty at Harvard as Director of Research in the Epilepsy Program at Boston Children’s Hospital and then as Professor and Chairman, Department of Pediatrics, Founder and Director of the Adult and Pediatric Epilepsy Program at the American University of Beirut. Dr. Mikati has had several international leadership roles including being President of the Union of the Middle Eastern and Mediterranean Pediatric Societies, on the Standing Committee of the International Pediatric Association, Officer of the International Child Neurology Association, Consultant to UNICEF, WHO, and the American Board of Pediatrics, and being one of only two Pediatric Neurologists, initially chosen worldwide, on the WHO advisory committee for the International Classification of Disease. He has received several national and international honors including, among others, Merritt Putnam American Epilepsy Society Fellowship Award, Harvard Community Health Plan Peer recognition Award, Debs Research Award, Hamdan Award for contributions to Medicine, Hans Zellweger Award for contributions to Pediatric Neurology, Patient Choice Award and the Michael Frank Award for research and lifetime contributions to the field of Pediatric Neurology.

Education and Training

  • Fellow in Neurology, Pediatrics, Harvard University , 1985 - 1987
  • Resident in Pediatric Neurology, Pediatrics, Harvard University , 1982 - 1985
  • Internship & Residency in Pediatrics, Pediatrics, American University of Beirut (Lebannon), 1979 - 1982
  • M.D., American University of Beirut (Lebannon), 1980

Publications

Bend, Renee, Lior Cohen, Melissa T. Carter, Michael J. Lyons, Dmitriy Niyazov, Mohamad A. Mikati, Samantha K. Rojas, et al. “Phenotype and mutation expansion of the PTPN23 associated disorder characterized by neurodevelopmental delay and structural brain abnormalities.” Eur J Hum Genet 28, no. 1 (January 2020): 76–87. https://doi.org/10.1038/s41431-019-0487-1.

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Uchitel, Julie, Errol Alden, Zulfiqar A. Bhutta, Jeffrey Goldhagen, Aditee Pradhan Narayan, Shanti Raman, Nick Spencer, et al. “The Rights of Children for Optimal Development and Nurturing Care.” Pediatrics 144, no. 6 (December 2019). https://doi.org/10.1542/peds.2019-0487.

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Uchitel, Julie, Ashley Helseth, Lyndsey Prange, Melissa McLean, Ryan Ghusayni, Monisha Sachdev, Arsen Hunanyan, and Mohamad A. Mikati. “The epileptology of alternating hemiplegia of childhood.” Neurology 93, no. 13 (September 24, 2019): e1248–59. https://doi.org/10.1212/WNL.0000000000008159.

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Sansevere, Arnold J., Ravindra Arya, Iván Sánchez Fernández, William D. Gaillard, Robert C. Tasker, Yi-Chen Lai, Anne E. Anderson, et al. “Electroencephalographic Reporting for Refractory Status Epilepticus.” J Clin Neurophysiol 36, no. 5 (September 2019): 365–70. https://doi.org/10.1097/WNP.0000000000000595.

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Mesraoua, Boulenouar, Dirk Deleu, Dimitri M. Kullmann, Ashok K. Shetty, Paul Boon, Emilio Perucca, Mohamad A. Mikati, and Ali A. Asadi-Pooya. “Novel therapies for epilepsy in the pipeline.” Epilepsy Behav 97 (August 2019): 282–90. https://doi.org/10.1016/j.yebeh.2019.04.042.

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Sánchez Fernández, Iván, Marina Gaínza-Lein, Nicholas S. Abend, Marta Amengual-Gual, Anne Anderson, Ravindra Arya, J Nicholas Brenton, et al. “The onset of pediatric refractory status epilepticus is not distributed uniformly during the day.” Seizure 70 (August 2019): 90–96. https://doi.org/10.1016/j.seizure.2019.06.017.

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Abdelnour, Elie, William Gallentine, Marie McDonald, Monisha Sachdev, Yong-Hui Jiang, and Mohamad A. Mikati. “Corrigendum to "Does age affect response to quinidine in patients with KCNT1 mutations? Report of three new cases and review of the literature" [Seizure 55 (February) (2018) 1-3].” Seizure 69 (July 2019): 305. https://doi.org/10.1016/j.seizure.2019.04.014.

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Jasien, Joan M., Melanie Bonner, Richard D’alli, Lyndsey Prange, Melissa Mclean, Monisha Sachdev, Julie Uchitel, Jennifer Ricano, Brian Smith, and Mohamad A. Mikati. “Cognitive, adaptive, and behavioral profiles and management of alternating hemiplegia of childhood.” Dev Med Child Neurol 61, no. 5 (May 2019): 547–54. https://doi.org/10.1111/dmcn.14077.

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Fernandes, Cecilia, and Mohamad A. Mikati. “The expanding spectrum of ATP1A3 related disease.” Eur J Paediatr Neurol 23, no. 3 (May 2019): 345–46. https://doi.org/10.1016/j.ejpn.2019.05.007.

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Helbig, Katherine L., Robert J. Lauerer, Jacqueline C. Bahr, Ivana A. Souza, Candace T. Myers, Betül Uysal, Niklas Schwarz, et al. “De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias.” Am J Hum Genet 104, no. 3 (March 7, 2019): 562. https://doi.org/10.1016/j.ajhg.2019.02.015.

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