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Mohamad Abdul Mikati, MD

Wilburt C. Davison Professor of Pediatrics, in the School of Medicine
Professor of Pediatrics
Chief, Division of Pediatric Neurology
Professor of Neurobiology
Faculty Network Member of the Duke Institute for Brain Sciences
Associate of the Duke Initiative for Science & Society
Affiliate of the Center for Brain Imaging and Analysis
Campus mail: Box 3936 Med Ctr, Durham, NC 27710
Phone: (919) 668-0477
Email address: mohamad.mikati@duke.edu

Mohamad A.  Mikati M.D., is the Wilburt C. Davison Professor of Pediatrics, Professor of Neurobiology, and Chief of the Division of Pediatric Neurology. Dr. Mikati’s clinical research has centered on characterization and therapy of pediatric epilepsy and neurology syndromes, describing several new pediatric neurological entities with two carrying his name (POSSUM syndromes # 3708 and 4468), developing novel therapeutic strategies for epilepsy and related disorders particularly Alternating Hemiplegia of Childhood, and applying cutting edge genetic and Magnetic Resonance Imaging techniques to drug resistant pediatric epilepsy.  In the laboratory he has elucidated mechanisms of seizure related neuronal injury, particularly those related to the ceramide pathway, and demonstrated neuroprotective effects of several agents including erythropoietin. Most recently he has concentrated his laboratory research on the pathophysiology of ATP1A3 dysfunction in the brain as model for epilepsy and of Alternating Hemiplegia of Childhood. He has more than 210 peer reviewed publications, 300 abstracts 40 chapters one book and two booklets. He also has more than 5,590 citations in the literature with an h-index of 44 and an i-10index of 118. Dr. Mikati has written chapters on epilepsy and related disorders in the major textbooks of Pediatrics and Pediatric Neurology including Swaiman’s Pediatric Neurology and Nelson’s Pediatrics. Before joining Duke in 2008 he had completed his M.D. and Pediatric training at the American University of Beirut, his Neurology at the Massachusetts General Hospital, his Neurophysiology at Boston Children’s Hospital and had been on the Faculty at Harvard as Director of Research in the Epilepsy Program at Boston Children’s Hospital and then as Professor and Chairman, Department of Pediatrics, Founder and Director of the Adult and Pediatric Epilepsy Program at the American University of Beirut. Dr. Mikati has had several international leadership roles including being President of the Union of the Middle Eastern and Mediterranean Pediatric Societies, on the Standing Committee of the International Pediatric Association, Officer of the International Child Neurology Association, Consultant to UNICEF, WHO, and the American Board of Pediatrics, and being one of only two Pediatric Neurologists, initially chosen worldwide, on the WHO advisory committee for the International Classification of Disease. He has received several national and international honors including, among others, Merritt Putnam American Epilepsy Society Fellowship Award, Harvard Community Health Plan Peer recognition Award, Debs Research Award, Hamdan Award for contributions to Medicine, Hans Zellweger Award for contributions to Pediatric Neurology, Patient Choice Award and the Michael Frank Award for research and lifetime contributions to the field of Pediatric Neurology.

Education and Training

  • Fellow in Neurology, Pediatrics, Harvard University , 1985 - 1987
  • Resident in Pediatric Neurology, Pediatrics, Harvard University , 1982 - 1985
  • Internship & Residency in Pediatrics, Pediatrics, American University of Beirut (Lebannon), 1979 - 1982
  • M.D., American University of Beirut (Lebannon), 1980

Publications

Kansagra, S, Ghusayni, R, Kherallah, B, Gunduz, T, McLean, M, Prange, L, Kravitz, RM, and Mikati, MA. "Polysomnography Findings and Sleep Disorders in Children With Alternating Hemiplegia of Childhood." Journal of Clinical Sleep Medicine : Jcsm : Official Publication of the American Academy of Sleep Medicine 15, no. 1 (January 15, 2019): 65-70.

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Helseth, AR, Hunanyan, AS, Adil, S, Linabarger, M, Sachdev, M, Abdelnour, E, Arehart, E, Szabo, M, Richardson, J, Wetsel, WC, Hochgeschwender, U, and Mikati, MA. "Novel E815K knock-in mouse model of alternating hemiplegia of childhood." Neurobiology of Disease 119 (November 2018): 100-112.

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Jasien, JM, Bonner, M, D'alli, R, Prange, L, Mclean, M, Sachdev, M, Uchitel, J, Ricano, J, Smith, B, and Mikati, MA. "Cognitive, adaptive, and behavioral profiles and management of alternating hemiplegia of childhood." Developmental Medicine and Child Neurology (October 26, 2018).

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Vasquez, A, Gaínza-Lein, M, Sánchez Fernández, I, Abend, NS, Anderson, A, Brenton, JN, Carpenter, JL, Chapman, K, Clark, J, Gaillard, WD, Glauser, T, Goldstein, J, Goodkin, HP, Lai, Y-C, Loddenkemper, T, McDonough, TL, Mikati, MA, Nayak, A, Payne, E, Riviello, J, Tchapyjnikov, D, Topjian, AA, Wainwright, MS, Tasker, RC, and Pediatric Status Epilepticus Research Group (pSERG), . "Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers." Pediatric Neurology 86 (September 2018): 33-41.

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Arya, R, Peariso, K, Gaínza-Lein, M, Harvey, J, Bergin, A, Brenton, JN, Burrows, BT, Glauser, T, Goodkin, HP, Lai, Y-C, Mikati, MA, Fernández, IS, Tchapyjnikov, D, Wilfong, AA, Williams, K, Loddenkemper, T, and pediatric Status Epilepticus Research Group (pSERG), . "Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus." Epilepsy Research 144 (August 2018): 1-6.

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Hunanyan, AS, Helseth, AR, Abdelnour, E, Kherallah, B, Sachdev, M, Chung, L, Masoud, M, Richardson, J, Li, Q, Nadler, JV, Moore, SD, and Mikati, MA. "Mechanisms of increased hippocampal excitability in the Mashl+/- mouse model of Na+ /K+ -ATPase dysfunction." Epilepsia 59, no. 7 (July 2018): 1455-1468.

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Winawer, MR, Griffin, NG, Samanamud, J, Baugh, EH, Rathakrishnan, D, Ramalingam, S, Zagzag, D, Schevon, CA, Dugan, P, Hegde, M, Sheth, SA, McKhann, GM, Doyle, WK, Grant, GA, Porter, BE, Mikati, MA, Muh, CR, Malone, CD, Bergin, AMR, Peters, JM, McBrian, DK, Pack, AM, Akman, CI, LaCoursiere, CM, Keever, KM, Madsen, JR, Yang, E, Lidov, HGW, Shain, C, Allen, AS, Canoll, PD, Crino, PB, Poduri, AH, and Heinzen, EL. "Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy." Annals of Neurology 83, no. 6 (June 2018): 1133-1146.

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Sinno, D, Tamim, H, Faytrouni, F, Mikati, MA, and Charafeddine, L. "Factors affecting child development assessed by the Ages and Stages Questionnaire (ASQ) in an Arabic speaking population." Early Human Development 120 (May 2018): 61-66.

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Sánchez Fernández, I, Gaínza-Lein, M, Abend, NS, Anderson, AE, Arya, R, Brenton, JN, Carpenter, JL, Chapman, KE, Clark, J, Gaillard, WD, Glauser, TA, Goldstein, JL, Goodkin, HP, Helseth, AR, Jackson, MC, Kapur, K, Lai, Y-C, McDonough, TL, Mikati, MA, Nayak, A, Peariso, K, Riviello, JJ, Tasker, RC, Tchapyjnikov, D, Topjian, AA, Wainwright, MS, Wilfong, A, Williams, K, Loddenkemper, T, and Pediatric Status Epilepticus Research Group (pSERG), . "Factors associated with treatment delays in pediatric refractory convulsive status epilepticus." Neurology 90, no. 19 (May 2018): e1692-e1701.

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Gaínza-Lein, M, Sánchez Fernández, I, Jackson, M, Abend, NS, Arya, R, Brenton, JN, Carpenter, JL, Chapman, KE, Gaillard, WD, Glauser, TA, Goldstein, JL, Goodkin, HP, Kapur, K, Mikati, MA, Peariso, K, Tasker, RC, Tchapyjnikov, D, Topjian, AA, Wainwright, MS, Wilfong, A, Williams, K, Loddenkemper, T, and Pediatric Status Epilepticus Research Group, . "Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus." Jama Neurology 75, no. 4 (April 2018): 410-418.

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