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Michael Scott Freemark, MD

Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine
Professor of Pediatrics
Chief, Divison of Pediatric Endocrinology
Affiliate, Duke Global Health Institute
Member of Sarah W. Stedman Nutrition and Metabolism Center
Campus mail: Box 102820 Med Ctr, Durham, NC 27710
Phone: (919) 684-8350
Email address: freem001@mc.duke.edu

The primary objective of my basic research has been to elucidate the roles of placental and fetal hormones in the regulation of maternal metabolism and fetal growth. My work has focused on the lactogenic hormones produced by the pituitary gland and placenta. In recent studies we have used targeted knockout mice to explore the molecular mechanisms by which prolactin and placental lactogen regulate pancreatic beta cell mass and insulin production during pregnancy and postnatal life.
I also have a clinical research interest in the pathogenesis and treatment of obesity and hyperlipidemia and the prevention of type 2 diabetes. In previous studies we showed that the drug metformin reduces fat stores and blood glucose and insulin levels in obese adolescents and may reduce the risk of progression to diabetes in selected patients. We have also examined the unique metabolic characteristics of Prader Willi syndrome, a genetic obesity disorder. Finally, we have recently completed a detailed study of metabolism in malnourished children in Uganda and characterized the effects of concurrent HIV infection on nutritional recovery.

Education and Training

  • M.D., Duke University, 1976
  • B.A., Brandeis University, 1972

Selected Grants and Awards

Publications

Arumugam, Ramamani, Don Fleenor, and Michael Freemark. “Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors..” Endocrine 32, no. 2 (October 2007): 182–91. https://doi.org/10.1007/s12020-007-9017-y.

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Freemark, Michael. “Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin..” Acta Paediatr 96, no. 9 (September 2007): 1326–32. https://doi.org/10.1111/j.1651-2227.2007.00429.x.

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Freemark, Michael. “Pharmacotherapy of childhood obesity: an evidence-based, conceptual approach..” Diabetes Care 30, no. 2 (February 2007): 395–402. https://doi.org/10.2337/dc06-1569.

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Arumugam, Ramamani, Don Fleenor, and Michael Freemark. “Lactogenic and somatogenic hormones regulate the expression of neuropeptide Y and cocaine- and amphetamine-regulated transcript in rat insulinoma (INS-1) cells: interactions with glucose and glucocorticoids..” Endocrinology 148, no. 1 (January 2007): 258–67. https://doi.org/10.1210/en.2006-0888.

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Fleenor, Don, Ramamani Arumugam, and Michael Freemark. “Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I..” Horm Res 66, no. 3 (2006): 101–10. https://doi.org/10.1159/000093667.

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Freemark, M. “Regulation of maternal metabolism by pituitary and placental hormones: roles in fetal development and metabolic programming..” Horm Res 65 Suppl 3 (2006): 41–49. https://doi.org/10.1159/000091505.

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Artz, Evelyn, Andrea Haqq, and Michael Freemark. “Hormonal and metabolic consequences of childhood obesity..” Endocrinol Metab Clin North Am 34, no. 3 (September 2005): 643–ix. https://doi.org/10.1016/j.ecl.2005.04.004.

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Speiser, Phyllis W., Mary C. J. Rudolf, Henry Anhalt, Cecilia Camacho-Hubner, Francesco Chiarelli, Alon Eliakim, Michael Freemark, et al. “Childhood obesity..” J Clin Endocrinol Metab 90, no. 3 (March 2005): 1871–87. https://doi.org/10.1210/jc.2004-1389.

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Fleenor, Donald, Jon Oden, Paul A. Kelly, Subburaman Mohan, Samira Alliouachene, Mario Pende, Sabrina Wentz, Jennifer Kerr, and Michael Freemark. “Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency..” Endocrinology 146, no. 1 (January 2005): 103–12. https://doi.org/10.1210/en.2004-0744.

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Freemark, M. “Type 2 diabetes in childhood: Diagnosis, pathogenesis, prevention, and treatment.” In Nutrition and Diabetes: Pathophysiology and Management, 177–204, 2005.

Scholars@Duke

Pages