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Michael Scott Freemark, MD

Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine
Professor of Pediatrics
Chief, Divison of Pediatric Endocrinology
Affiliate, Duke Global Health Institute
Member of Sarah W. Stedman Nutrition and Metabolism Center
Campus mail: Box 102820 Med Ctr, Durham, NC 27710
Phone: (919) 684-8350
Email address: freem001@mc.duke.edu

The primary objective of my basic research has been to elucidate the roles of placental and fetal hormones in the regulation of maternal metabolism and fetal growth. My work has focused on the lactogenic hormones produced by the pituitary gland and placenta. In recent studies we have used targeted knockout mice to explore the molecular mechanisms by which prolactin and placental lactogen regulate pancreatic beta cell mass and insulin production during pregnancy and postnatal life.
I also have a clinical research interest in the pathogenesis and treatment of obesity and hyperlipidemia and the prevention of type 2 diabetes. In previous studies we showed that the drug metformin reduces fat stores and blood glucose and insulin levels in obese adolescents and may reduce the risk of progression to diabetes in selected patients. We have also examined the unique metabolic characteristics of Prader Willi syndrome, a genetic obesity disorder. Finally, we have recently completed a detailed study of metabolism in malnourished children in Uganda and characterized the effects of concurrent HIV infection on nutritional recovery.

Education and Training

  • M.D., Duke University, 1976
  • B.A., Brandeis University, 1972

Selected Grants and Awards

Publications

Freemark, Michael. “Metabolomics in nutrition research: biomarkers predicting mortality in children with severe acute malnutrition..” Food Nutr Bull 36, no. 1 Suppl (March 2015): S88–92. https://doi.org/10.1177/15648265150361S114.

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Newbern, D., P. Gumus Balikcioglu, M. Balikcioglu, J. Bain, M. Muehlbauer, R. Stevens, O. Ilkayeva, et al. “Erratum: Sex differences in biomarkers associated with insulin resistance in obese adolescents: Metabolomic profiling and principal components analysis (Journal of Clinical Endocrinology and Metabolism (2014) 99 (4730-4739) DOI: 10.1210/jc.2014-2080).” Journal of Clinical Endocrinology and Metabolism 100, no. 4 (January 1, 2015). https://doi.org/10.1210/jc.2015-1354.

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Newbern, Dorothee, Pinar Gumus Balikcioglu, Metin Balikcioglu, James Bain, Michael Muehlbauer, Robert Stevens, Olga Ilkayeva, et al. “Sex differences in biomarkers associated with insulin resistance in obese adolescents: metabolomic profiling and principal components analysis..” J Clin Endocrinol Metab 99, no. 12 (December 2014): 4730–39. https://doi.org/10.1210/jc.2014-2080.

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Irizarry, K. A., M. Freemark, and D. Newbern. “Endocrinopathies of the Premature Infant.” In Beyond the NICU: Comprehensive Care of the High-Risk Infant Comprehensive Care of the High-Risk Infant, edited by W. malcolm. McGraw Hill Professional, 2014.

Scholars@Duke

Freemark, Michael. “Predictors of childhood obesity and pathogenesis of comorbidities..” Pediatr Ann 43, no. 9 (September 2014): 357–60. https://doi.org/10.3928/00904481-20140825-06.

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Irizarry, Krystal A., Valerie Brito, and Michael Freemark. “Screening for metabolic and reproductive complications in obese children and adolescents..” Pediatr Ann 43, no. 9 (September 2014): e210–17. https://doi.org/10.3928/00904481-20140825-07.

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Arumugam, Ramamani, Don Fleenor, and Michael Freemark. “Knockdown of prolactin receptors in a pancreatic beta cell line: effects on DNA synthesis, apoptosis, and gene expression..” Endocrine 46, no. 3 (August 2014): 568–76. https://doi.org/10.1007/s12020-013-0073-1.

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Bartz, Sarah, Aaloke Mody, Christoph Hornik, James Bain, Michael Muehlbauer, Tonny Kiyimba, Elizabeth Kiboneka, et al. “Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality..” J Clin Endocrinol Metab 99, no. 6 (June 2014): 2128–37. https://doi.org/10.1210/jc.2013-4018.

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Mody, Aaloke, Sarah Bartz, Christoph P. Hornik, Tonny Kiyimba, James Bain, Michael Muehlbauer, Elizabeth Kiboneka, et al. “Effects of HIV infection on the metabolic and hormonal status of children with severe acute malnutrition..” Plos One 9, no. 7 (2014). https://doi.org/10.1371/journal.pone.0102233.

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Auffret, Julien, Michael Freemark, Nadège Carré, Yves Mathieu, Cécile Tourrel-Cuzin, Marc Lombès, Jamileh Movassat, and Nadine Binart. “Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period..” Am J Physiol Endocrinol Metab 305, no. 10 (November 15, 2013): E1309–18. https://doi.org/10.1152/ajpendo.00636.2012.

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