Skip to main content

Michael Scott Freemark, MD

Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine
Professor of Pediatrics
Chief, Divison of Pediatric Endocrinology
Affiliate, Duke Global Health Institute
Member of Sarah W. Stedman Nutrition and Metabolism Center
Campus mail: Box 102820 Med Ctr, Durham, NC 27710
Phone: (919) 684-8350
Email address: freem001@mc.duke.edu

The primary objective of my basic research has been to elucidate the roles of placental and fetal hormones in the regulation of maternal metabolism and fetal growth. My work has focused on the lactogenic hormones produced by the pituitary gland and placenta. In recent studies we have used targeted knockout mice to explore the molecular mechanisms by which prolactin and placental lactogen regulate pancreatic beta cell mass and insulin production during pregnancy and postnatal life.
I also have a clinical research interest in the pathogenesis and treatment of obesity and hyperlipidemia and the prevention of type 2 diabetes. In previous studies we showed that the drug metformin reduces fat stores and blood glucose and insulin levels in obese adolescents and may reduce the risk of progression to diabetes in selected patients. We have also examined the unique metabolic characteristics of Prader Willi syndrome, a genetic obesity disorder. Finally, we have recently completed a detailed study of metabolism in malnourished children in Uganda and characterized the effects of concurrent HIV infection on nutritional recovery.

Education and Training

  • M.D., Duke University, 1976
  • B.A., Brandeis University, 1972

Selected Grants and Awards

Publications

Shashi, Vandana, Loren D. M. Pena, Katherine Kim, Barbara Burton, Maja Hempel, Kelly Schoch, Magdalena Walkiewicz, et al. “De Novo Truncating Variants in ASXL2 Are Associated with a Unique and Recognizable Clinical Phenotype..” Am J Hum Genet 100, no. 1 (January 5, 2017). https://doi.org/10.1016/j.ajhg.2016.12.004.

Full Text

Owino, Victor, Tahmeed Ahmed, Michael Freemark, Paul Kelly, Alexander Loy, Mark Manary, and Cornelia Loechl. “Environmental Enteric Dysfunction and Growth Failure/Stunting in Global Child Health..” Pediatrics 138, no. 6 (December 2016). https://doi.org/10.1542/peds.2016-0641.

Full Text

Shashi, Vandana, Loren D. M. Pena, Katherine Kim, Barbara Burton, Maja Hempel, Kelly Schoch, Magdalena Walkiewicz, et al. “De Novo Truncating Variants in ASXL2 Are Associated with a Unique and Recognizable Clinical Phenotype..” Am J Hum Genet 99, no. 4 (October 6, 2016): 991–99. https://doi.org/10.1016/j.ajhg.2016.08.017.

Full Text

Irizarry, Krystal A., Mark Miller, Michael Freemark, and Andrea M. Haqq. “Prader Willi Syndrome: Genetics, Metabolomics, Hormonal Function, and New Approaches to Therapy..” Adv Pediatr 63, no. 1 (August 2016): 47–77. https://doi.org/10.1016/j.yapd.2016.04.005.

Full Text

Tamborlane, William V., Morey W. Haymond, David Dunger, Ravi Shankar, Rose Gubitosi-Klug, Kathleen Bethin, Janina Karres, et al. “Expanding Treatment Options for Youth With Type 2 Diabetes: Current Problems and Proposed Solutions.” Diabetes Care 39, no. 3 (March 2016): 323–29. https://doi.org/10.2337/dc15-1649.

Full Text

Irizarry, Krystal A., James Bain, Merlin G. Butler, Olga Ilkayeva, Michael Muehlbauer, Andrea M. Haqq, and Michael Freemark. “Metabolic profiling in Prader-Willi syndrome and nonsyndromic obesity: sex differences and the role of growth hormone..” Clin Endocrinol (Oxf) 83, no. 6 (December 2015): 797–805. https://doi.org/10.1111/cen.12766.

Full Text

Freemark, M. “Liraglutide in Weight Management.” The New England Journal of Medicine 373, no. 18 (October 29, 2015): 1780–81. https://doi.org/10.1056/NEJMc1509759#SA4.

Full Text

Freemark, Michael. “Liraglutide in Weight Management..” N Engl J Med 373, no. 18 (October 29, 2015): 1780–81. https://doi.org/10.1056/NEJMc1509759.

Full Text

Gumus Balikcioglu, Pinar, Metin Balikcioglu, Michael J. Muehlbauer, Jonathan Q. Purnell, David Broadhurst, Michael Freemark, and Andrea M. Haqq. “Macronutrient Regulation of Ghrelin and Peptide YY in Pediatric Obesity and Prader-Willi Syndrome..” J Clin Endocrinol Metab 100, no. 10 (October 2015): 3822–31. https://doi.org/10.1210/jc.2015-2503.

Full Text

Tan, Queenie K-G, David W. Stockton, Eniko Pivnick, Asim F. Choudhri, Stacy Hines-Dowell, Loren D. M. Pena, Melissa A. Deimling, Michael S. Freemark, and Priya S. Kishnani. “Premature pubarche in children with Pompe disease..” J Pediatr 166, no. 4 (April 2015): 1075-8.e1. https://doi.org/10.1016/j.jpeds.2014.12.074.

Full Text

Pages