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Michael Scott Freemark, MD

Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine
Professor of Pediatrics
Chief, Divison of Pediatric Endocrinology
Affiliate, Duke Global Health Institute
Member of Sarah W. Stedman Nutrition and Metabolism Center
Campus mail: Box 102820 Med Ctr, Durham, NC 27710
Phone: (919) 684-8350
Email address: freem001@mc.duke.edu

The primary objective of my basic research has been to elucidate the roles of placental and fetal hormones in the regulation of maternal metabolism and fetal growth. My work has focused on the lactogenic hormones produced by the pituitary gland and placenta. In recent studies we have used targeted knockout mice to explore the molecular mechanisms by which prolactin and placental lactogen regulate pancreatic beta cell mass and insulin production during pregnancy and postnatal life.
I also have a clinical research interest in the pathogenesis and treatment of obesity and hyperlipidemia and the prevention of type 2 diabetes. In previous studies we showed that the drug metformin reduces fat stores and blood glucose and insulin levels in obese adolescents and may reduce the risk of progression to diabetes in selected patients. We have also examined the unique metabolic characteristics of Prader Willi syndrome, a genetic obesity disorder. Finally, we have recently completed a detailed study of metabolism in malnourished children in Uganda and characterized the effects of concurrent HIV infection on nutritional recovery.

Education and Training

  • M.D., Duke University, 1976
  • B.A., Brandeis University, 1972

Publications

Simmons, JH, Foster, NC, Riddlesworth, TD, DuBose, SN, Redondo, MJ, Liu, E, and Freemark, M. "Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry." Pediatric Diabetes 19, no. 4 (June 2018): 741-748.

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Freemark, MS. "Freemark M and Collins S. Brown adipose tissue and body weight regulation. In Freemark, M (editor). Pediatric Obesity: Etiology, pathogenesis and treatment. Second Edition. Springer Humana Press, 2018." February 1, 2018. (Chapter)

Scholars@Duke

Freemark, MS. "Freemark M. Childhood obesity in the modern age: global trends, determinants, complications and costs. In Freemark, M (editor). Pediatric Obesity: Etiology, pathogenesis and treatment. Second Edition. Springer Humana Press, 2018." February 1, 2018. (Chapter)

Scholars@Duke

Freemark, MS. "Freemark M. Obesity and the endocrine system 1: pathogenesis of weight gain in endocrine and metabolic disorders. In Freemark, M (editor). Pediatric Obesity: Etiology, pathogenesis and treatment. Second Edition. Springer Humana Press, 2018." February 1, 2018. (Chapter)

Scholars@Duke

Freemark, MS. "Freemark M. Obesity and the endocrine system 2: effects of childhood obesity on growth and bone maturation, thyroid and adrenal function, sexual development, and bone mineralization. In Freemark, M (editor). Pediatric Obesity: Etiology, pathogenesis and treatment. Second Edition. Springer Humana Press, 2018." February 1, 2018. (Chapter)

Scholars@Duke

Christian, M, Gerreffi, G, and Gereffi, G. "Fast Food Value Chains and Childhood Obesity: A Global Perspective." In Pediatric Obesity: Etiology, Pathogenesis and Treatment,edited by MS Freemark, 717-730. Humana Press, , Springer International POublishing, January 10, 2018. (Chapter)

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Freemark, M. "Endothelial dysfunction and cardiovascular disease in childhood obesity(Accepted)." Jornal De Pediatria (January 1, 2018).

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Freemark, M. "Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry. Simmons JH, Foster NC, Riddlesworth TD, DuBose SN, Redondo MJ, Liu E, Freemark M; T1D Exchange Clinic Network." Pediatric Diabetes (December 22, 2017).

Scholars@Duke

Freemark, M. "Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry. Simmons JH, Foster NC, Riddlesworth TD, DuBose SN, Redondo MJ, Liu E, Freemark M; T1D Exchange Clinic Network." Pediatric Diabetes (December 22, 2017).

Scholars@Duke

Page, LC, Shi, M, and Freemark, M. "Early-Onset Obesity Caused by Monogenic Disorders." Current Pediatrics Reports 5, no. 3 (September 2017): 100-110.

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