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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and the Department of Immunology at Duke University Medical Center. Research in the Moody lab is focused on understanding the B cell responses during infection, vaccination, and disease. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at the Duke Human Vaccine Institute (DHVI). The Moody lab is currently funded to study influenza, syphilis, HIV-1, and emerging infectious diseases.

Dr. Moody is the director of the Duke CIVICs Vaccine Center (DCVC) at (DHVI) and co-director of the Centers for Research of Emerging Infectious Disease Coordinating Center (CREID-CC). Dr. Moody is co-PI of a U19 program to develop a syphilis vaccine; this program is led by Dr. Justin Radolf at the University of Connecticut. Dr. Moody is also the director of the DHVI Accessioning Unit, a biorepository that provides support for work occurring at DHVI and with its many collaborators around the world by providing processing, shipping, and inventory support for a wide array of projects.

Dr. Moody and his team are involved in many networks studying vaccine response including the Collaborative Influenza Vaccine Innovation Centers (CIVICs), HIV Vaccine Trials Network (HVTN) and the COVID-19 Prevention Network (CoVPN).

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Gao, Feng, Mattia Bonsignori, Hua-Xin Liao, Amit Kumar, Shi-Mao Xia, Xiaozhi Lu, Fangping Cai, et al. “Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.” Cell 158, no. 3 (July 31, 2014): 481–91. https://doi.org/10.1016/j.cell.2014.06.022.

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Jackson, Katherine J. L., Yi Liu, Krishna M. Roskin, Jacob Glanville, Ramona A. Hoh, Katie Seo, Eleanor L. Marshall, et al. “Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements.” Cell Host Microbe 16, no. 1 (July 9, 2014): 105–14. https://doi.org/10.1016/j.chom.2014.05.013.

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Pollara, Justin, Mattia Bonsignori, M Anthony Moody, Pinghuang Liu, S Munir Alam, Kwan-Ki Hwang, Thaddeus C. Gurley, et al. “HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities.” J Virol 88, no. 14 (July 2014): 7715–26. https://doi.org/10.1128/JVI.00156-14.

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Garcia, Ambrosia, Sarah Keinonen, Ana M. Sanchez, Guido Ferrari, Thomas N. Denny, and M Anthony Moody. “Leukopak PBMC sample processing for preparing quality control material to support proficiency testing programs.” J Immunol Methods 409 (July 2014): 99–106. https://doi.org/10.1016/j.jim.2014.05.019.

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Haynes, Barton F., M Anthony Moody, Munir Alam, Mattia Bonsignori, Laurent Verkoczy, Guido Ferrari, Feng Gao, Georgia D. Tomaras, Hua-Xin Liao, and Garnett Kelsoe. “Progress in HIV-1 vaccine development.” J Allergy Clin Immunol 134, no. 1 (July 2014): 3–10. https://doi.org/10.1016/j.jaci.2014.04.025.

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Madani, Navid, Amy M. Princiotto, Arne Schön, Judith LaLonde, Yu Feng, Ernesto Freire, Jongwoo Park, et al. “CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies.” J Virol 88, no. 12 (June 2014): 6542–55. https://doi.org/10.1128/JVI.00540-14.

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Liu, Pinghuang, Latonya D. Williams, Xiaoying Shen, Mattia Bonsignori, Nathan A. Vandergrift, R Glenn Overman, M Anthony Moody, et al. “Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.” J Virol 88, no. 9 (May 2014): 5165–70. https://doi.org/10.1128/JVI.03765-13.

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Moody, M Anthony. “Modulation of HIV-1 immunity by adjuvants.” Curr Opin Hiv Aids 9, no. 3 (May 2014): 242–49. https://doi.org/10.1097/COH.0000000000000052.

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Bonsignori, Mattia, Kevin Wiehe, Sebastian K. Grimm, Rebecca Lynch, Guang Yang, Daniel M. Kozink, Florence Perrin, et al. “An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.” J Clin Invest 124, no. 4 (April 2014): 1835–43. https://doi.org/10.1172/JCI73441.

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Holl, T Matt, Guang Yang, Masayuki Kuraoka, Laurent Verkoczy, S Munir Alam, M Anthony Moody, Barton F. Haynes, and Garnett Kelsoe. “Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes.” J Immunol 192, no. 7 (April 1, 2014): 3269–79. https://doi.org/10.4049/jimmunol.1302829.

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