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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and Assistant Professor of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza, syphilis, autoimmunity, and is interested in applying the technique to other disease processes.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Hraber, Peter, Bette Korber, Kshitij Wagh, Elena E. Giorgi, Tanmoy Bhattacharya, S. Gnanakaran, Alan S. Lapedes, et al. “Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants..” Viruses 7, no. 10 (October 21, 2015): 5443–75. https://doi.org/10.3390/v7102881.

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Moody, M Anthony, Feng Gao, Thaddeus C. Gurley, Joshua D. Amos, Amit Kumar, Bhavna Hora, Dawn J. Marshall, et al. “Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses..” Cell Host Microbe 18, no. 3 (September 9, 2015): 354–62. https://doi.org/10.1016/j.chom.2015.08.006.

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Amos, Joshua D., Jonathon E. Himes, Lawrence Armand, Thaddeus C. Gurley, David R. Martinez, Lisa Colvin, Krista Beck, et al. “Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys..” J Virol 89, no. 18 (September 2015): 9485–98. https://doi.org/10.1128/JVI.01564-15.

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Williams, Wilton B., Hua-Xin Liao, M Anthony Moody, Thomas B. Kepler, S Munir Alam, Feng Gao, Kevin Wiehe, et al. “HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies..” Science 349, no. 6249 (August 14, 2015). https://doi.org/10.1126/science.aab1253.

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Santra, Sampa, Georgia D. Tomaras, Ranjit Warrier, Nathan I. Nicely, Hua-Xin Liao, Justin Pollara, Pinghuang Liu, et al. “Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques..” Plos Pathog 11, no. 8 (August 2015). https://doi.org/10.1371/journal.ppat.1005042.

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Permar, Sallie R., Youyi Fong, Nathan Vandergrift, Genevieve G. Fouda, Peter Gilbert, Robert Parks, Frederick H. Jaeger, et al. “Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission..” J Clin Invest 125, no. 7 (July 1, 2015): 2702–6. https://doi.org/10.1172/JCI81593.

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Chuang, Gwo-Yu, Baoshan Zhang, Krisha McKee, Sijy O’Dell, Young Do Kwon, Tongqing Zhou, Julie Blinn, et al. “Eliminating antibody polyreactivity through addition of N-linked glycosylation..” Protein Sci 24, no. 6 (June 2015): 1019–30. https://doi.org/10.1002/pro.2682.

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Schmidt, Aaron G., Matthew D. Therkelsen, Shaun Stewart, Thomas B. Kepler, Hua-Xin Liao, M Anthony Moody, Barton F. Haynes, and Stephen C. Harrison. “Viral receptor-binding site antibodies with diverse germline origins..” Cell 161, no. 5 (May 21, 2015): 1026–34. https://doi.org/10.1016/j.cell.2015.04.028.

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Fouda, Genevieve G., M Anthony Moody, and Sallie R. Permar. “Antibodies for prevention of mother-to-child transmission of HIV-1..” Curr Opin Hiv Aids 10, no. 3 (May 2015): 177–82. https://doi.org/10.1097/COH.0000000000000150.

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Xu, H., A. G. Schmidt, T. O’Donnell, M. D. Therkelsen, T. B. Kepler, M. A. Moody, B. F. Haynes, H. X. Liao, S. C. Harrison, and D. E. Shaw. “Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.” Proteins: Structure, Function and Bioinformatics 83, no. 4 (April 1, 2015): 771–80. https://doi.org/10.1002/prot.24745.

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