Skip to main content

Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and Assistant Professor of Immunology at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza, syphilis, autoimmunity, and is interested in applying the technique to other disease processes.

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Raymond, Donald D., Shaun M. Stewart, Jiwon Lee, Jack Ferdman, Goran Bajic, Khoi T. Do, Michael J. Ernandes, et al. “Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain..” Nat Med 22, no. 12 (December 2016): 1465–69. https://doi.org/10.1038/nm.4223.

Full Text

Bradley, Todd, Ashley Trama, Nancy Tumba, Elin Gray, Xiaozhi Lu, Navid Madani, Fatemeh Jahanbakhsh, et al. “Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity..” Ebiomedicine 12 (October 2016): 196–207. https://doi.org/10.1016/j.ebiom.2016.08.045.

Full Text

Buchbinder, Susan, Nicole Grunenberg, Brittany Sanchez, Kelly Seaton, Guido Ferrari, M Anthony Moody, Nicole Frahm, et al. “DNA/MVA HIV Vaccine Producing Virus-like Particles (VLPs) Is Well-tolerated and Induces Durable Functional Antibodies (Abs) in HVTN 094.” In Aids Research and Human Retroviruses, 32:99–99. MARY ANN LIEBERT, INC, 2016.

Scholars@Duke

Doria-Rose, Nicole A., Shelly Krebs, Wiliam Law, Syna Gift, Agnes Chenine, Morgane Rolland, M Anthony Moody, et al. “HIV-1 MPER-directed Broadly Neutralizing Antibodies from an Acute-infection Cohort RV217 Subject.” In Aids Research and Human Retroviruses, 32:36–36. MARY ANN LIEBERT, INC, 2016.

Scholars@Duke

Madani, Navid, Amy Princiotto, David Easterhoff, Todd Bradley, Kan Luo, M Anthony Moody, Ganesh Phad, et al. “Prevention of Vaginal Transmission of Simian-Human Immunodeficiency Virus (SHIV) in Rhesus Monkeys by Small-molecule CD4-mimetic Compounds.” In Aids Research and Human Retroviruses, 32:129–129. MARY ANN LIEBERT, INC, 2016.

Scholars@Duke

Saleh, Ezzeldin, M Anthony Moody, and Emmanuel B. Walter. “Effect of antipyretic analgesics on immune responses to vaccination..” Hum Vaccin Immunother 12, no. 9 (September 2016): 2391–2402. https://doi.org/10.1080/21645515.2016.1183077.

Full Text

Tay, Matthew Zirui, Pinghuang Liu, LaTonya D. Williams, Michael D. McRaven, Sheetal Sawant, Thaddeus C. Gurley, Thomas T. Xu, et al. “Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses..” Plos Pathog 12, no. 8 (August 2016). https://doi.org/10.1371/journal.ppat.1005817.

Full Text

Moody, M Anthony, Isabela Pedroza-Pacheco, Nathan A. Vandergrift, Cecilia Chui, Krissey E. Lloyd, Robert Parks, Kelly A. Soderberg, et al. “Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies..” Sci Immunol 1, no. 1 (July 29, 2016). https://doi.org/10.1126/sciimmunol.aag0851.

Full Text

Dudley, Dawn M., Matthew T. Aliota, Emma L. Mohr, Andrea M. Weiler, Gabrielle Lehrer-Brey, Kim L. Weisgrau, Mariel S. Mohns, et al. “A rhesus macaque model of Asian-lineage Zika virus infection..” Nat Commun 7 (June 28, 2016). https://doi.org/10.1038/ncomms12204.

Full Text

Bushey, Ryan T., M Anthony Moody, Nathan L. Nicely, Barton F. Haynes, S Munir Alam, Stephen T. Keir, Rex C. Bentley, et al. “A Therapeutic Antibody for Cancer, Derived from Single Human B Cells..” Cell Rep 15, no. 7 (May 17, 2016): 1505–13. https://doi.org/10.1016/j.celrep.2016.04.038.

Full Text

Pages