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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and the Department of Immunology at Duke University Medical Center. Research in the Moody lab is focused on understanding the B cell responses during infection, vaccination, and disease. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at the Duke Human Vaccine Institute (DHVI). The Moody lab is currently funded to study influenza, syphilis, HIV-1, and emerging infectious diseases.

Dr. Moody is the director of the Duke CIVICs Vaccine Center (DCVC) at (DHVI) and co-director of the Centers for Research of Emerging Infectious Disease Coordinating Center (CREID-CC). Dr. Moody is co-PI of a U19 program to develop a syphilis vaccine; this program is led by Dr. Justin Radolf at the University of Connecticut. Dr. Moody is also the director of the DHVI Accessioning Unit, a biorepository that provides support for work occurring at DHVI and with its many collaborators around the world by providing processing, shipping, and inventory support for a wide array of projects.

Dr. Moody and his team are involved in many networks studying vaccine response including the Collaborative Influenza Vaccine Innovation Centers (CIVICs), HIV Vaccine Trials Network (HVTN) and the COVID-19 Prevention Network (CoVPN).

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Bonsignori, Mattia, and M Anthony Moody. “Simultaneous Detection of Antigen-Specific IgG- and IgM-Secreting Cells with a B Cell Fluorospot Assay.” Cells 1, no. 1 (March 21, 2012): 15–26. https://doi.org/10.3390/cells1010015.

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McWilliams, L. M., K. Y. Su, X. Liang, S. Floyd, J. Amos, M. Moody, G. Kelsoe, and M. Kuraoka. “CD27+ Developing B Cells are Common in Human Fetal Liver.” In Journal of Allergy and Clinical Immunology, 129:AB12–AB12. Elsevier BV, 2012. https://doi.org/10.1016/j.jaci.2011.12.906.

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Li, Liuzhe, Xiao-Hong Wang, Sagarika Banerjee, Barbara Volsky, Constance Williams, M Anthony Moody, Susan Zolla-Pazner, and Miroslaw K. Gorny. “Clonal analysis of human anti-V3 monoclonal antibodies selected by a V3 tetramer.” Hum Antibodies 21, no. 3–4 (2012): 65–73. https://doi.org/10.3233/HAB-130264.

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Friedman, James, S Munir Alam, Xiaoying Shen, Shi-Mao Xia, Shelley Stewart, Kara Anasti, Justin Pollara, et al. “Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum.” Plos One 7, no. 5 (2012): e37648. https://doi.org/10.1371/journal.pone.0037648.

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Zhu, Zhongyu, Haiyan Rebekah Qin, Weizao Chen, Qi Zhao, Xiaoying Shen, Robert Schutte, Yanping Wang, et al. “Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies.” J Virol 85, no. 21 (November 2011): 11401–8. https://doi.org/10.1128/JVI.05312-11.

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Liao, Hua-Xin, Xi Chen, Supriya Munshaw, Ruijun Zhang, Dawn J. Marshall, Nathan Vandergrift, John F. Whitesides, et al. “Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated.” J Exp Med 208, no. 11 (October 24, 2011): 2237–49. https://doi.org/10.1084/jem.20110363.

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Zhu, Z., H. R. Qin, W. Chen, Q. Zhao, X. Shen, R. Schutte, Y. Wang, et al. “2F5-like Cross-Reactive HIV-1-Neutralizing Monoclonal Antibodies with Low Number of Somatic Mutations.” In Aids Research and Human Retroviruses, 27:A9–A9. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Bonsignori, Mattia, Kwan-Ki Hwang, Xi Chen, Chun-Yen Tsao, Lynn Morris, Elin Gray, Dawn J. Marshall, et al. “Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors.” J Virol 85, no. 19 (October 2011): 9998–10009. https://doi.org/10.1128/JVI.05045-11.

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Bonsignori, M., X. Wu, M. A. Moody, H. Liao, K. Hwang, J. A. Crump, S. H. Capiga, et al. “Isolation of CD4-Binding Site and V2/V3 Conformational (Quaternary) Broadly Neutralizing Antibodies from the Same HIV-1 Infected African Subject.” In Aids Research and Human Retroviruses, 27:A120–A120. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Ferrari, G., J. Pollara, D. Kozink, T. Harms, M. Drinker, S. Freel, M. A. Moody, et al. “Mapping of ADCC Activity: The A32 Conformational C1 Epitope is a Dominant Target for ADCC Antibodies in Chronically HIV-1 Infected Subjects.” In Aids Research and Human Retroviruses, 27:A66–A66. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

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