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Michael Anthony Moody, MD

Associate Professor of Pediatrics
Associate Professor in the Department of Immunology
Member of the Duke Human Vaccine Institute
Campus mail: 2 Genome Ct, MSRB II Room 3007, Durham, NC 27710
Phone: (919) 668-2551
Email address: tony.moody@duke.edu

Tony Moody, MD is an Associate Professor in the Department of Pediatrics, Division of Infectious Diseases and the Department of Immunology at Duke University Medical Center. Research in the Moody lab is focused on understanding the B cell responses during infection, vaccination, and disease. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at the Duke Human Vaccine Institute (DHVI). The Moody lab is currently funded to study influenza, syphilis, HIV-1, and emerging infectious diseases.

Dr. Moody is the director of the Duke CIVICs Vaccine Center (DCVC) at (DHVI) and co-director of the Centers for Research of Emerging Infectious Disease Coordinating Center (CREID-CC). Dr. Moody is co-PI of a U19 program to develop a syphilis vaccine; this program is led by Dr. Justin Radolf at the University of Connecticut. Dr. Moody is also the director of the DHVI Accessioning Unit, a biorepository that provides support for work occurring at DHVI and with its many collaborators around the world by providing processing, shipping, and inventory support for a wide array of projects.

Dr. Moody and his team are involved in many networks studying vaccine response including the Collaborative Influenza Vaccine Innovation Centers (CIVICs), HIV Vaccine Trials Network (HVTN) and the COVID-19 Prevention Network (CoVPN).

Education and Training

  • Fellowship, Pediatric Infectious Diseases, Pediatrics, Duke University, 2003 - 2006
  • Pediatric Chief Resident, Pediatrics, Emory University, 2002 - 2003
  • Pediatric Internship & Residency, Pediatrics, Emory University, 1999 - 2002
  • M.D., Duke University, 1999

Selected Grants and Awards

Publications

Bonsignori, M., K. Wiehe, R. M. Lynch, S. K. Grimm, D. M. Kozink, K. Hwang, J. A. Eudailey, et al. “Isolation and Characterization of an Autoreactive CD4bs Broad Neutralizing Antibody from a Chronic HIV-1 Controller with Systemic Lupus Erythematosus.” In Aids Research and Human Retroviruses, 29:A45–46. MARY ANN LIEBERT, INC, 2013.

Scholars@Duke

Zhang, R., M. Moody, M. Alam, J. Yu, S. Santra, G. Kelsoe, S. Sekaran, et al. “Isolation of mAbs from Sorted Single B Cells by RT/PCR for Analysis of B Cell Responses to HIV-1 MPER Epitope in Vaccinated Rhesus Macaques.” In Aids Research and Human Retroviruses, 29:A30–A30. MARY ANN LIEBERT, INC, 2013.

Scholars@Duke

Chen, Y., J. Zhang, H. Bouton-Verville, A. Newman, S. Xia, H. Liao, D. C. Montefiori, et al. “Lipid Components in MPER-Based Immunization Regimens Are Critical for Inducing Broadly Neutralizing Antibody Responses in 2F5 and 4E10 Knockin Mice.” In Aids Research and Human Retroviruses, 29:A20–A20. MARY ANN LIEBERT, INC, 2013.

Scholars@Duke

McWilliams, Laurie, Kuei-Ying Su, Xiaoe Liang, Dongmei Liao, Serina Floyd, Joshua Amos, M Anthony Moody, Garnett Kelsoe, and Masayuki Kuraoka. “The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors.” J Leukoc Biol 94, no. 5 (November 2013): 991–1001. https://doi.org/10.1189/jlb.0113048.

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Amos, Joshua D., Andrew B. Wilks, Genevieve G. Fouda, Shannon D. Smith, Lisa Colvin, Tatenda Mahlokozera, Carrie Ho, et al. “Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys.” J Virol 87, no. 20 (October 2013): 11121–34. https://doi.org/10.1128/JVI.01887-13.

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Moody, A. A. “Microbial Vaccine Development” 2 (August 29, 2013): 1119–28. https://doi.org/10.1016/B978-0-12-382227-7.00095-1.

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Pollara, Justin, Mattia Bonsignori, M Anthony Moody, Marzena Pazgier, Barton F. Haynes, and Guido Ferrari. “Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses.” Curr Hiv Res 11, no. 5 (July 2013): 378–87. https://doi.org/10.2174/1570162x113116660059.

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Yates, N. L., A. R. Stacey, T. L. Nolen, N. A. Vandergrift, M. A. Moody, D. C. Montefiori, K. J. Weinhold, et al. “HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life.” Mucosal Immunol 6, no. 4 (July 2013): 692–703. https://doi.org/10.1038/mi.2012.107.

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Liu, Pinghuang, Nicole L. Yates, Xiaoying Shen, Mattia Bonsignori, M Anthony Moody, Hua-Xin Liao, Youyi Fong, et al. “Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees.” J Virol 87, no. 14 (July 2013): 7828–36. https://doi.org/10.1128/JVI.02737-12.

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Tomaras, Georgia D., Guido Ferrari, Xiaoying Shen, S Munir Alam, Hua-Xin Liao, Justin Pollara, Mattia Bonsignori, et al. “Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG.” Proc Natl Acad Sci U S A 110, no. 22 (May 28, 2013): 9019–24. https://doi.org/10.1073/pnas.1301456110.

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