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Laura Eve Schanberg, MD

Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: Box 3212 Med Ctr, Durham, NC 27710
Phone: (919) 684-6575

I am involved in both hypothesis driven clinical research as well as clinical trials, both of which are described below. 

My research team consists of health psychologists, medical fellows, and graduate students in clinical psychology. Most broadly, the research team has interests in studying stress and coping processes in children with chronic disease and their families. Particular interests include describing the pain experience of children with chronic arthritis and the role of parental processes in child adjustment to chronic disease. 

We continue to investigate the daily pain of children with arthritis in real time and their responses to pain, including activity and school function, as well as emotional regulation. In addition, we are examining the responses of parents to their child's pain in real time recorded using an electronic device.

I am also active in the several clinic trials in pediatric rheumatology. I was the Principal Investigator for an NIH funded 21 center interventional trial entitled Prevention of Cardiovascular Complications of SLE: Atherosclerosis Prevention in Pediatric Lupus (APPLE) in conjunction with the Duke Clinical Research Institute (DCRI) and the Childhood Arthritis and Rheumatology Research Association (CARRA). This trial enrolled 221 children and adolescents with SLE and studied the efficacy and safety of statin therapy in children with SLE. The results have been published. Currently I am leading several clinical research efforts including both industry and investigator initiated clinical trials. 

I am actively engaged with the CARRA network strengthening and broadening research infrastructure to make more pediatric rheumatology sites able to participate in clinical research, including testing consensus treatment plans developed by CARRA members for pediatric rheumatic diseases and a national registry of rheumatic disease to study medication safety and comparative effectiveness. This effort was jump started by a grant from the NIH as part of the American Recovery Act but is now supported by industry and the Arthritis Foundation. The CARRA registry includes 60 CARRA sites and has enrolled 1700 children with JIA since reopening in July 2015.  From this information, we hope to learn more about the outcomes of childhood rheumatic disease and establish best treatment practices. The CARRA Registry will be adding SLE in 2017 as well as several other pediatric rheumatic diseases. 

Education and Training

  • Research Fellow, Duke University School of Medicine, 1988 - 1991
  • Rheumatology Clinical Fellowship, Pediatrics, Duke University School of Medicine, 1987 - 1988
  • Residency, Pediatrics, Duke University School of Medicine, 1984 - 1987
  • M.D., Duke University, 1984

Selected Grants and Awards

Publications

Mann, Courtney M., Molly McFatrich, Justin N. Baker, Antonia V. Bennett, David R. Freyer, Pamela S. Hinds, Nicole Lucas, et al. “Responsiveness of PROMIS (R) Pediatric measures to changes in health-related quality of life among children and adolescents undergoing treatment for cancer.” In Quality of Life Research, 28:S149–S149. SPRINGER, 2019.

Scholars@Duke

Schanberg, Laura E., Athimalaipet V. Ramanan, Fabrizio De Benedetti, Timothy Beukelman, Guy S. Eakin, Vincent Del Gaizo, Sarah Ringold, et al. “Toward Accelerated Authorization and Access to New Medicines for Juvenile Idiopathic Arthritis..” Arthritis Rheumatol, July 16, 2019. https://doi.org/10.1002/art.41043.

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O’Brien, Emily C., Ana Maria Rodriguez, Hye-Chung Kum, Laura E. Schanberg, Marcy Fitz-Randolph, Sean M. O’Brien, and Soko Setoguchi. “Patient perspectives on the linkage of health data for research: Insights from an online patient community questionnaire..” Int J Med Inform 127 (July 2019): 9–17. https://doi.org/10.1016/j.ijmedinf.2019.04.003.

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Ofili, Elizabeth O., Laura E. Schanberg, Barbara Hutchinson, Felix Sogade, Icilma Fergus, Phillip Duncan, Joe Hargrove, et al. “The Association of Black Cardiologists (ABC) Cardiovascular Implementation Study (CVIS): A Research Registry Integrating Social Determinants to Support Care for Underserved Patients..” Int J Environ Res Public Health 16, no. 9 (May 10, 2019). https://doi.org/10.3390/ijerph16091631.

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Connelly, Mark, Laura E. Schanberg, Stacy Ardoin, Michael Blakley, Ruy Carrasco, Peter Chira, Kristen Hayward, et al. “Multisite Randomized Clinical Trial Evaluating an Online Self-Management Program for Adolescents With Juvenile Idiopathic Arthritis..” J Pediatr Psychol 44, no. 3 (April 1, 2019): 363–74. https://doi.org/10.1093/jpepsy/jsy066.

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Balevic, Stephen J., Thomas P. Green, Megan E. B. Clowse, Amanda M. Eudy, Laura E. Schanberg, and Michael Cohen-Wolkowiez. “Pharmacokinetics of Hydroxychloroquine in Pregnancies with Rheumatic Diseases..” Clin Pharmacokinet 58, no. 4 (April 2019): 525–33. https://doi.org/10.1007/s40262-018-0712-z.

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Mulvihill, Evan, Stacy Ardoin, Susan D. Thompson, Bi Zhou, Gakit Richard Yu, Emily King, Nora Singer, et al. “Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic lupus erythematosus (SLE)..” Lupus Sci Med 6, no. 1 (2019). https://doi.org/10.1136/lupus-2019-000333.

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Manzi, Susan, Sandra Raymond, Karin Tse, Yaritza Peña, Annick Anderson, Kathleen Arntsen, Sang-Cheol Bae, et al. “Global consensus building and prioritisation of fundamental lupus challenges: the ALPHA project..” Lupus Sci Med 6, no. 1 (2019). https://doi.org/10.1136/lupus-2019-000342.

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Balevic, Stephen J., Michael Cohen-Wolkowiez, Amanda M. Eudy, Thomas P. Green, Laura E. Schanberg, and Megan E. B. Clowse. “Hydroxychloroquine Levels throughout Pregnancies Complicated by Rheumatic Disease: Implications for Maternal and Neonatal Outcomes..” J Rheumatol 46, no. 1 (January 2019): 57–63. https://doi.org/10.3899/jrheum.180158.

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Schanberg, Laura E., and C Daniel Mullins. “If patients are the true north, patient-centeredness should guide research..” Nat Rev Rheumatol 15, no. 1 (January 2019): 5–6. https://doi.org/10.1038/s41584-018-0129-y.

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