Laura Eve Schanberg, MD
I am involved in both hypothesis driven clinical research as well as clinical trials, both of which are described below.
My research team consists of health psychologists, medical fellows, and graduate students in clinical psychology. Most broadly, the research team has interests in studying stress and coping processes in children with chronic disease and their families. Particular interests include describing the pain experience of children with chronic arthritis and the role of parental processes in child adjustment to chronic disease.
We continue to investigate the daily pain of children with arthritis in real time and their responses to pain, including activity and school function, as well as emotional regulation. In addition, we are examining the responses of parents to their child's pain in real time recorded using an electronic device.
I am also active in the several clinic trials in pediatric rheumatology. I was the Principal Investigator for an NIH funded 21 center interventional trial entitled Prevention of Cardiovascular Complications of SLE: Atherosclerosis Prevention in Pediatric Lupus (APPLE) in conjunction with the Duke Clinical Research Institute (DCRI) and the Childhood Arthritis and Rheumatology Research Association (CARRA). This trial enrolled 221 children and adolescents with SLE and studied the efficacy and safety of statin therapy in children with SLE. The results have been published. Currently I am leading several clinical research efforts including both industry and investigator initiated clinical trials.
I am actively engaged with the CARRA network strengthening and broadening research infrastructure to make more pediatric rheumatology sites able to participate in clinical research, including testing consensus treatment plans developed by CARRA members for pediatric rheumatic diseases and a national registry of rheumatic disease to study medication safety and comparative effectiveness. This effort was jump started by a grant from the NIH as part of the American Recovery Act but is now supported by industry and the Arthritis Foundation. The CARRA registry includes 60 CARRA sites and has enrolled 1700 children with JIA since reopening in July 2015. From this information, we hope to learn more about the outcomes of childhood rheumatic disease and establish best treatment practices. The CARRA Registry will be adding SLE in 2017 as well as several other pediatric rheumatic diseases.
Education and Training
- Research Fellow, Duke University School of Medicine, 1988 - 1991
- Rheumatology Clinical Fellowship, Pediatrics, Duke University School of Medicine, 1987 - 1988
- Residency, Pediatrics, Duke University School of Medicine, 1984 - 1987
- M.D., Duke University, 1984
Selected Grants and Awards
- Improving Outcomes in Limited Juvenile Idiopathic Arthritis
- Sub-Q JIA (LIMIT)
- Duke CTSA (KL2)
- Duke CTSA (TL1)
- DCRI CARRA Registry
- A Randomized, Open Label, Multi-Center, Phase 3 Efficacy Study of Sub-Q Abatacept in Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA)
- Comparative Effectiveness of CARRA Treatment Strategies for Polyarticular Juvenile Idiopathic Arthritis
- Expanding HL7 FHIR to support post-marketing research and surveillance within multi-source, chronic disease registries
- CARRA Accelerating Toward an Evidence Based in Pediatric Rheumatology
- Urinary HER2 as a biomarker for lupus nephritis
- Duke Research Training Program for Pediatricians
- Comparison of Methotrexate and Biologics in JIA (COMPARE-JIA)
- Training Program in Inflammatory and Immunological Diseases
- Enhancing CARRA Research: Integration and Dissemination of Clinical Data
- Pediatric Rheumatology Research Annual Scientific Meeting
- WebSMART Trial-Year 4
- PULSE: Pediatric Update on Lupus in South Africa: Epidemiology & Management
- CARRA Planning Grant-Subcontract to UAB
- Risk stratification using genetic and microbial determinants in childhood onset RA
- Standardizing and Optimizing Childhood Lupus Nephritis Treatment through CARRA
- CARRA_Cooperative Agreement for Clinical Research in Children with Rheumatic Disaeses
- CARRA: Accelerating Toward an Evidence Based Culture in Pediatric Rheumatology
- Electronic Diary Assessment of Pain in Juvenile Arthritis
- Prevention of Cardiovascular Complications of Pediatric SLE
- Nitric Oxide Metabolism in Statin-treated Pediatric SLE
- Stress, Mood & Disease Activity In Juvenile Rheumatoid Art
- Regulation Of The T Cell Specific Gene Cd7
- Regulation Of The T-Cell Specific Gene Cd7
- Regulation Of The T Cell-Specific Gene Cd7