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Jennifer Lilly Turi, MD

Associate Professor of Pediatrics
Campus mail: 371 Sands, Durham, NC 27710
Phone: (919) 681-5560
Email address: turi0002@mc.duke.edu

A primary goal of my research to date has been to elucidate the impact of inflammation on disordered iron handling in the lung, both as a mechanism of oxidant injury and persistent infection as well as an etiology of inflammatory lung disease itself.  In particular, I have focused on the importance of cellular iron transport regulation in airway epithelial cells as a means to detoxify the lungs against metal containing particulates and iron liberated from microbes.  Clinically, hemolysis following cardiopulmonary presents an excessive iron and heme load to the body and may overwhelm the body’s protective mechanisms.  The oxidant generation and cellular toxicity that result may contribute to the generation of multi-organ dysfunction. Therefore, more recent translational investigation has focused on acute lung and kidney injury following CPB-induced hemolysis and as well as potential mechanisms to mitigate this effect.   

Education and Training

  • Fellow, Pediatric Critical Care Medicine, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatric, U Mass Memorial Medical Center, 1996 - 1998
  • Intern, Pediatrics, U Mass Memorial Medical Center, 1995 - 1996
  • M.D., U Mass Memorial Medical Center, 1995

Publications

Ghio, AJ, Tong, H, Soukup, J, Dailey, LA, Cheng, W, Samet, JM, Kesic, MJ, Bromberg, PA, Turi, JL, Upadhyay, D, Budinger, GR, and Mutlu, GM. "Sequestration of mitochondrial iron by silica particle initiates a biological effect (Am J Physiol Lung Cell Mol Physiol, 305, (L712-L724), (2013), 10.1152/ajplung.00099.2013)." American Journal of Physiology Lung Cellular and Molecular Physiology 315, no. 5 (November 1, 2018): L919-null.

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Williams, DC, Turi, JL, Hornik, CP, Bonadonna, DK, Williford, WL, Walczak, RJ, Watt, KM, and Cheifetz, IM. "Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis." Asaio Journal (American Society for Artificial Internal Organs : 1992) 61, no. 2 (March 2015): 190-195.

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Williams, DC, Turi, JL, Hornik, CP, Bonadonna, DK, Williford, WL, Walczak, RJ, Watt, KM, and Cheifetz, IM. "Circuit Oxygenator Contributes to Extracorporeal Membrane Oxygenation-Induced Hemolysis." Asaio Journal 61, no. 2 (January 1, 2015): 190-195.

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Mamikonian, LS, Mamo, LB, Smith, PB, Koo, J, Lodge, AJ, and Turi, JL. "Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*." Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 15, no. 3 (March 2014): e111-e119.

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Rehder, KJ, Turi, JL, and Cheifetz, IM. "Acute respiratory failure." In Pediatric Critical Care Medicine: Volume 1: Care of the Critically Ill or Injured Child, Second Edition, 401-412. January 1, 2014.

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Mamikonian, LS, Mamo, LB, Smith, PB, Koo, J, Lodge, AJ, and Turi, JL. "Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*." Pediatric Critical Care Medicine 15, no. 3 (January 1, 2014).

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Ghio, AJ, Tong, H, Soukup, JM, Dailey, LA, Cheng, W-Y, Samet, JM, Kesic, MJ, Bromberg, PA, Turi, JL, Upadhyay, D, Scott Budinger, GR, and Mutlu, GM. "Sequestration of mitochondrial iron by silica particle initiates a biological effect." American Journal of Physiology. Lung Cellular and Molecular Physiology 305, no. 10 (November 2013): L712-L724.

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Ozment, CP, Mamo, LB, Campbell, ML, Lokhnygina, Y, Ghio, AJ, and Turi, JL. "Transfusion-related biologic effects and free hemoglobin, heme, and iron." Transfusion 53, no. 4 (April 2013): 732-740.

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Ghio, AJ, Soukup, JM, Dailey, LA, Richards, JH, Turi, JL, Pavlisko, EN, and Roggli, VL. "Disruption of iron homeostasis in mesothelial cells after talc pleurodesis." Am J Respir Cell Mol Biol 46, no. 1 (January 2012): 80-86.

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Frazier, MD, Mamo, LB, Ghio, AJ, and Turi, JL. "Hepcidin expression in human airway epithelial cells is regulated by interferon-γ. (Published online)" Respir Res 12 (August 2, 2011): 100-.

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