Jennifer Lilly Turi, MD
A primary goal of my research to date has been to elucidate the impact of inflammation on disordered iron handling in the lung, both as a mechanism of oxidant injury and persistent infection as well as an etiology of inflammatory lung disease itself. In particular, I have focused on the importance of cellular iron transport regulation in airway epithelial cells as a means to detoxify the lungs against metal containing particulates and iron liberated from microbes. Clinically, hemolysis following cardiopulmonary presents an excessive iron and heme load to the body and may overwhelm the body’s protective mechanisms. The oxidant generation and cellular toxicity that result may contribute to the generation of multi-organ dysfunction. Therefore, more recent translational investigation has focused on acute lung and kidney injury following CPB-induced hemolysis and as well as potential mechanisms to mitigate this effect.
Education and Training
- Fellow, Pediatric Critical Care Medicine, Pediatrics, Duke University, 1998 - 2001
- Resident, Pediatric, U Mass Memorial Medical Center, 1996 - 1998
- Intern, Pediatrics, U Mass Memorial Medical Center, 1995 - 1996
- M.D., U Mass Memorial Medical Center, 1995