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Jennifer Lilly Turi, MD

Associate Professor of Pediatrics
Campus mail: 371 Sands, Durham, NC 27710
Phone: (919) 681-5560
Email address: turi0002@mc.duke.edu

A primary goal of my research to date has been to elucidate the impact of inflammation on disordered iron handling in the lung, both as a mechanism of oxidant injury and persistent infection as well as an etiology of inflammatory lung disease itself.  In particular, I have focused on the importance of cellular iron transport regulation in airway epithelial cells as a means to detoxify the lungs against metal containing particulates and iron liberated from microbes.  Clinically, hemolysis following cardiopulmonary presents an excessive iron and heme load to the body and may overwhelm the body’s protective mechanisms.  The oxidant generation and cellular toxicity that result may contribute to the generation of multi-organ dysfunction. Therefore, more recent translational investigation has focused on acute lung and kidney injury following CPB-induced hemolysis and as well as potential mechanisms to mitigate this effect.   

Education and Training

  • Fellow, Pediatric Critical Care Medicine, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatric, U Mass Memorial Medical Center, 1996 - 1998
  • Intern, Pediatrics, U Mass Memorial Medical Center, 1995 - 1996
  • M.D., U Mass Memorial Medical Center, 1995

Publications

Ghio, A. J., H. Tong, J. Soukup, L. A. Dailey, W. Cheng, J. M. Samet, M. J. Kesic, et al. “Sequestration of mitochondrial iron by silica particle initiates a biological effect (Am J Physiol Lung Cell Mol Physiol, 305, (L712-L724), (2013), 10.1152/ajplung.00099.2013).” American Journal of Physiology  Lung Cellular and Molecular Physiology 315, no. 5 (November 1, 2018). https://doi.org/10.1152/ajplung.zh5-7547-corr.2018.

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Williams, Duane C., Jennifer L. Turi, Christoph P. Hornik, Desiree K. Bonadonna, Walter L. Williford, Richard J. Walczak, Kevin M. Watt, and Ira M. Cheifetz. “Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis..” Asaio J 61, no. 2 (March 2015): 190–95. https://doi.org/10.1097/MAT.0000000000000173.

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Mamikonian, Lara S., Lisa B. Mamo, P Brian Smith, Jeannie Koo, Andrew J. Lodge, and Jennifer L. Turi. “Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*..” Pediatr Crit Care Med 15, no. 3 (March 2014): e111–19. https://doi.org/10.1097/PCC.0000000000000047.

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Rehder, K. J., J. L. Turi, and I. M. Cheifetz. “Acute respiratory failure.” In Pediatric Critical Care Medicine: Volume 1: Care of the Critically Ill or Injured Child, Second Edition, 401–12, 2014. https://doi.org/10.1007/978-1-4471-6362-6_31.

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Ghio, Andrew J., Haiyan Tong, Joleen M. Soukup, Lisa A. Dailey, Wan-Yun Cheng, James M. Samet, Matthew J. Kesic, et al. “Sequestration of mitochondrial iron by silica particle initiates a biological effect..” Am J Physiol Lung Cell Mol Physiol 305, no. 10 (November 15, 2013): L712–24. https://doi.org/10.1152/ajplung.00099.2013.

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Ozment, Caroline P., Lisa B. Mamo, Mary Lee Campbell, Yuliya Lokhnygina, Andrew J. Ghio, and Jennifer L. Turi. “Transfusion-related biologic effects and free hemoglobin, heme, and iron..” Transfusion 53, no. 4 (April 2013): 732–40. https://doi.org/10.1111/j.1537-2995.2012.03837.x.

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Ghio, Andrew J., Joleen M. Soukup, Lisa A. Dailey, Judy H. Richards, Jennifer L. Turi, Elizabeth N. Pavlisko, and Victor L. Roggli. “Disruption of iron homeostasis in mesothelial cells after talc pleurodesis..” Am J Respir Cell Mol Biol 46, no. 1 (January 2012): 80–86. https://doi.org/10.1165/rcmb.2011-0168OC.

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Frazier, Marie D., Lisa B. Mamo, Andrew J. Ghio, and Jennifer L. Turi. “Hepcidin expression in human airway epithelial cells is regulated by interferon-γ..” Respir Res 12 (August 2, 2011). https://doi.org/10.1186/1465-9921-12-100.

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Ozment, Caroline P., and Jennifer L. Turi. “Iron overload following red blood cell transfusion and its impact on disease severity..” Biochim Biophys Acta 1790, no. 7 (July 2009): 694–701. https://doi.org/10.1016/j.bbagen.2008.09.010.

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Turi, Jennifer L., Claude A. Piantadosi, Jackie D. Stonehuerner, and Andrew J. Ghio. “Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport..” Biometals 21, no. 5 (October 2008): 571–80. https://doi.org/10.1007/s10534-008-9143-x.

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