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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor of Pediatrics
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 50 of the most commonly used medicines in children. Each of these trials is conducted under an investigational new drug (IND) application with guidance from the Food and Drug Administration for labeling.

Signature programs of the Network include clinical trials in premature, term infants and most recently, obese children. Over the past 10 years, Dr. Benjamin’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Dr. Benjamin is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Dr. Benjamin’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows (including two T32 programs sponsored by NIH for which he is PI), and multiple junior faculty.

Dr. Benjamin has published over 250 works with up to 7000 citations. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina at Chapel Hill, 2003
  • M.P.H., University of North Carolina at Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Smith, P Brian, and Daniel K. Benjamin. “Neonatal-perinatal infections: an update.” Clin Perinatol 42, no. 1 (March 2015): xix–xx. https://doi.org/10.1016/j.clp.2014.12.001.

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Kelly, Matthew S., Daniel K. Benjamin, and P Brian Smith. “The epidemiology and diagnosis of invasive candidiasis among premature infants.” Clin Perinatol 42, no. 1 (March 2015): 105–ix. https://doi.org/10.1016/j.clp.2014.10.008.

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Watt, K., M. Cohen-Wolkowiez, D. Williams, D. Bonadonna, I. Cheifetz, D. K. Benjamin, and K. L. Brouwer. “ANTIFUNGAL EXTRACTION BY THE EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) CIRCUIT EX VIVO.” In Clinical Pharmacology & Therapeutics, 97:S16–S16. WILEY-BLACKWELL, 2015.

Scholars@Duke

Hope, William W., Atsunori Kaibara, Michael Roy, Antonio Arrieta, Nkechi Azie, Laura L. Kovanda, and Daniel K. Benjamin. “Population pharmacokinetics of micafungin and its metabolites M1 and M5 in children and adolescents.” Antimicrob Agents Chemother 59, no. 2 (February 2015): 905–13. https://doi.org/10.1128/AAC.03736-14.

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Autmizguine, Julie, Christoph P. Hornik, Daniel K. Benjamin, Matthew M. Laughon, Reese H. Clark, C Michael Cotten, Michael Cohen-Wolkowiez, P Brian Smith, and P Brian Best Pharmaceuticals for Children Act—Pediatric Trials Network Administrative Core Committee. “Anaerobic antimicrobial therapy after necrotizing enterocolitis in VLBW infants.” Pediatrics 135, no. 1 (January 2015): e117–25. https://doi.org/10.1542/peds.2014-2141.

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Samiee-Zafarghandy, Samira, Sudha R. Raman, John N. van den Anker, Kerstin McHutchison, Christoph P. Hornik, Reese H. Clark, P. Brian Smith, and P. Best Pharmaceuticals for Children Act—Pediatric Trials Network Administrative Core Committee. “Safety of milrinone use in neonatal intensive care units.” Early Hum Dev 91, no. 1 (January 2015): 31–35. https://doi.org/10.1016/j.earlhumdev.2014.10.007.

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Gonzalez, Daniel, Chiara Melloni, Brenda B. Poindexter, Ram Yogev, Andrew M. Atz, Janice E. Sullivan, Susan R. Mendley, et al. “Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots.” Bioanalysis 7, no. 9 (2015): 1137–49. https://doi.org/10.4155/bio.15.38.

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Cohen-Wolkowiez, Michael, and Daniel K. Benjamin. “Editorial commentary: Fluconazole therapeutic drug monitoring in children with cancer: not today.” Clin Infect Dis 59, no. 11 (December 1, 2014): 1534–36. https://doi.org/10.1093/cid/ciu661.

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Benjamin, Daniel K. “Career Profile.” Clinical Pharmacology & Therapeutics 96, no. 4 (October 1, 2014): 411–411.

Scholars@Duke

Gonzalez, Daniel, Ian M. Paul, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Advances in pediatric pharmacology, therapeutics, and toxicology.” Adv Pediatr 61, no. 1 (August 2014): 7–31. https://doi.org/10.1016/j.yapd.2014.03.005.

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